Academic Articles & Research Papers

Semi-rational design and modification of phosphoketolase to improve the yield of tyrosol in Saccharomyces cerevisiae

Tyrosol is an important component of pharmaceuticals, nutraceuticals, and cosmetics, and their biosynthetic pathways are currently a hot research topic. d-Erythrose 4-phosphate is a key precursor for the biosynthesis of tyrosol in Saccharom...

Technology and innovation in global health leadership education: A new model

Health technology innovations

The global pandemic has drastically impacted older adults in numerous ways (e.g., loneliness; age discrimination; mental and physical health; limited access to traditional health care).On the other hand, it may have accelerated the general ...

From Health Technology Assessment to Health Technology Sustainability

This paper aims to propose a methodological lens to the assessment of technological innovations in healthcare based on the principles of social, economic, and political sustainability. Starting from the consideration of a lack of a unified ...

Molecular Informatics, Chemometrics, and Sensory Omics for Constructing an Umami Peptide Cluster Library Across the Entire Lager Beer Brewing Process

Umami taste in lager beer not only determined body fullness and the backbone of aftertaste, but also affected the controllability and interpretability of flavor expression across the entire brewing process. Based on stage-wise sampling, pep...

Physical, psychological and behavioural responses of aircraft occupants to volcanic emissions

Abstract Volcanic eruptions produce plumes of ash, gas and aerosols that present a risk to aviation at all standard flight levels. Here, we investigate atmospheric dispersal of volcanic emissions, whether and how they infiltrate aircraft, a...

Corrigendum: New Sesquiterpenoids From Plant-Associated Irpex lacteus

Health Technology Assessment

This article describes health technology assessment (HTA) as an evaluation tool that applies systematic methods of inquiry to the generation and use of health technologies and new products. The focus of this article is on the contributions ...

Health Technologies and Decision Making

Health technology has the tremendous potential to change our understanding of disease, transform the delivery of health-care services, and improve health outcomes. But using such technology comes at a price. Health Technologies and Decision...

Purification, Characterization and Bactericidal Action of Lysozyme, Isolated from <i>Bacillus subtillis</i> BSN314: A Disintegrating Effect of Lysozyme on Gram-Positive and Gram-Negative Bacteria

In the present study, lysozyme was purified by the following multi-step methodology: salt (ammonium sulfate) precipitation, dialysis, and ultrafiltration. The lysozyme potential was measured by enzymatic activity after each purification ste...

Health technology and health technology assessment

In addition to the doctor, technology is an essential aspect of healthcare. In many parts of the world, a visit to the doctor does not feel complete without a prescription for a drug. Advanced laboratory and imaging technology is indispensa...

Health Technologies and Innovation in the Global Health Arena

Although many health technologies are indispensible to global health, many are inaccessible in developing countries. Yet most of the health technologies needed in such countries are not expensive, and there are ways to ensure their appropri...

Exploring barriers and enablers to implementing a digital mental health crisis risk mitigation pathway in acute paediatric care: A multi-site, exploratory mixed-methods study

Objective Children and young people (CYP) presenting in mental health crisis to acute paediatric settings represent a growing clinical and system-level challenge. These environments, primarily designed for physical healthcare, frequently la...

Hackathons as Stepping Stones in Health Care Innovation: Case Study With Systematic Recommendations

BackgroundUntil recently, developing health technologies was time-consuming and expensive, and often involved patients, doctors, and other health care professionals only as passive recipients of the end product. So far, users have been mini...

Demonstration of high value care to improve oral health of a remote Indigenous community in Australia

Abstract Background The oral health of Indigenous children in remote communities is much worse than other population groups in Australia. Providing and maintaining an oral health service is challenging due to the remoteness of communities, ...

Deep learning-based multimodal data fusion in bone tumor management: Advances in clinical decision support

Bone tumors (BTs)—including osteosarcoma, Ewing sarcoma, and chondrosarcoma—are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location, histological subtype, and molecular alterations. Re...

‘Optimal’ cutoff selection in studies of depression screening tool accuracy using the PHQ‐9, EPDS, or HADS‐D: A meta‐research study

Abstract Objectives Optimal cutoff thresholds are selected to separate ‘positive’ from ‘negative’ screening results. We evaluated how depression screening tool studies select optimal cutoffs. Methods We included studies from previously cond...

Challenges and conditions for successfully implementing and adopting the telematics infrastructure in German outpatient healthcare: A qualitative study applying the NASSS framework

Background Germany's healthcare system provides high-quality, universal health coverage to almost all residents. However, a major challenge lies in the strong separation of healthcare structures, which hinders efficient interprofessional an...

Quantum computing in medical informatics

In an era of exponential technological advancements, the integration of quantum computing (QC) and medical informatics emerges as a captivating frontier, promising to unlock a new realm of possibilities for healthcare. QC, harnessing the pr...

Artificial intelligence-driven anthropometric assessment for young children: evaluating the accuracy and practicality of a digital image-based length and weight prediction tool

Background Monitoring early childhood growth is vital, as growth faltering could indicate nutritional or health issues requiring prompt intervention. Our study’s aim was to assess the performance of a length-weight artificial intelligence (...