Academic Articles & Research Papers

A Familial Case of Multiple Endocrine Neoplasia 2A: From Morphology to Genetic Alterations Penetration in Three Generations of a Family

This paper illustrates a rare syndrome of multiple endocrine neoplasia type 2A (MEN2A) in a family of three generations. In our case, the father, son and one daughter developed phaeochromocytoma (PHEO) and medullary thyroid carcinoma (MTC) ...

Higher calorie intake with adequate exercise is associated with reduced mortality compared with low-calorie diet with equivalent exercise: An observational study from NHANES based on the 2020–2025 Dietary Guidelines for Americans

Object: To explore the effects of different combinations of calorie intake and exercise on all-cause, cardiovascular and cancer mortality. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weigh...

Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cel...

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults

Background: Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether ...

The interplay of risk factors for future falls and fall-related injuries among community-dwelling older adults: a Bayesian network analysis

Abstract Background Falls are a leading global cause of injury and mortality in older adults, necessitating understanding risk factor interplay for prevention. This study aims to investigate complex interactions among risk factors associate...

Stage-Dependent Within-Individual Comparison Reveals SIV-Specific Activation/Exhaustion Shift in Rhesus Macaques

It is challenging to trace the complicated individual-based variations of HIV-specific immunocompetence shift during the successful antiretroviral therapy (ART) era. Using eight rhesus monkeys simulating a longitudinal stage-dependent cohor...

Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis

Background: Previous studies have consistently demonstrated that exercise mitigates cognitive decline in older adults. However, the most effective types of exercise, along with optimal frequency and duration of interventions, remain inadequ...

Fluidity in filial piety: twenty-year associations of living arrangements on depression and life satisfaction and across chronic diseases among older adults in rural China

Abstract Objectives Based on defamilization, individualization, and contingent intergenerational solidarity theories, this study developed a cultural defamilization framework. Longitudinal data were used to explore changes in the associatio...

Effects of electron beam welding on the microstructure and impact properties of three reconstituted steels

Specimen reconstitution technology is important for the in-service safety of reactor pressure vessels (RPVs) in nuclear power plants. To verify the feasibility of electron beam welding for the restructured specimens, the electron beam weldi...

One-step fabrication of superhydrophobic fabrics with stable mechanical performance in harsh conditions

Abstract Developing robust water-repellent textiles is critical for outdoor, protective, and industrial applications. However, achieving long-lasting water repellency under mechanical stress remains a significant challenge. Conventional app...

Improved object detection method for autonomous driving based on DETR

Object detection is a critical component in the development of autonomous driving technology and has demonstrated significant growth potential. To address the limitations of current techniques, this paper presents an improved object detecti...

Comparative Study of Electrochemical Biosensors Based on Highly Efficient Mesoporous ZrO2‑Ag-G-SiO2 and In2O3‑G-SiO2 for Rapid Recognition of E. coli O157:H7

Influence of chemical composition and discontinuities on energy transformation and rock mass behaviour: Insights into geological dynamic

Abstract In this study, efforts were made to incorporate the influence of discontinuities and failure modes of rock into the classification of rock masses. The past tectonic activities may create microfractures in the rock body therefore th...

Thermoelectric properties of high pressure synthesized lithium and calcium double-filled CoSb3

Lithium and calcium are inefficient filling elements of CoSb3 at ambient pressure, but show nice filling behavior under high pressure. In this work, we synthesized Li/Ca double-filled CoSb3 with high pressure synthesis method. The products ...

Effect of Corrosion Product Films Induced by Tensile Stress on P110 Casing Steels Induced in CO2 Environment

Corrosion product films were formed on P110 casing steels by high-temperature and high-pressure autoclave in a CO2 environment induced by tensile stress. The effects of applied tensile stress on the protection characteristics and electroche...

Effect of Prior Rolling on Microstructures and Property of Diffusion-Bonded Mg/Al Alloy

In this study, magnesium alloy AZ91, which was cast by double roll casting system, was rolled by a rolling mill. Then, rolled magnesium alloy and magnesium alloy without being rolled were, respectively, welded with aluminum alloy 6061 by di...

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Smart drug delivery nano-systems show significant changes in their physical or chemical properties in response to slight change in environmental physical and/or chemical signals, and further releasing drugs adjusted to the progression of th...

Properties of aniline or O-phenylenediamine/YBCO hybrid materials

YBa2Cu3O7-δ(YBCO) bulk material prepared by high temperature solid state reaction was milled and dispersed through ultrasonic process in ethanol to prepare nanoscale YBCO/ethanol sol. Then it was mixed with aniline or O-phenylenediamine and...

Dynamic Assembly of Microgels and Polymers at Non‐Aqueous Liquid/Liquid Interfaces

Abstract Particle assembly at liquid–liquid interfaces presents a promising bottom‐up strategy for creating supramolecular materials with advanced functionalities. However, the significantly lower interfacial tension observed in immiscible ...

A hybrid nanomodulator enables metabolic microenvironment remodeling for potent immunotherapy against lung adenocarcinoma

STING agonist-based immunotherapy holds considerable promise for cancer treatment, yet its efficacy against immunologically “cold” tumors such as lung adenocarcinoma (LUAD) remains markedly limited. A major obstacle lies in the highly glyco...