Academic Articles & Research Papers

Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes

Abstract Background Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1) and its m...

Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico Analysis

Altered expression of protein coding gene (PCG) and long non-coding RNA (lncRNA) have been identified in SARS-CoV-2 infected cells and tissues from COVID-19 patients. The functional role and mechanism (s) of transcriptional regulation of de...

Improved Immunohistochemistry of Mouse Eye Sections Using Davidson's Fixative and Melanin Bleaching

Immunohistochemistry (IHC) and immunofluorescence (IF) are fundamental molecular biology techniques to assess protein expression. However, the melanin present normally in the eye in the uveal tract (choroid, iris, and ciliary body) and the ...

Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair

Abstract Background Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. We aim to co...

Case report: Rapid development of amyloid A amyloidosis in temporal arteritis with SAA1.3 allele; An unusual case of intestinal amyloidosis secondary to temporal arteritis

Temporal arteritis (TA) is a large-vessel vasculitis mostly seen in older patients. Amyloid A (AA) amyloidosis secondary to a chronic inflammation induces multiple organ dysfunctions, including a dysfunction of the gastrointestinal tract. H...

Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions

Summary: Detecting antibodies, particularly those targeting donor human leukocyte antigens in organ transplantation and self-antigens in autoimmune diseases, is crucial for diagnosis and therapy. Radioprotective 105 (RP105), a Toll-like rec...

Causal analysis between altered levels of interleukins and obstructive sleep apnea

BackgroundInflammation proteins including interleukins (ILs) have been reported to be related to obstructive sleep apnea (OSA). The aims of this study were to estimate the levels for several key interleukins in OSA and the causal effects be...

A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin

Abstract Background Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogen...

Single Eye mRNA-Seq Reveals Normalisation of the Retinal Microglial Transcriptome Following Acute Inflammation

Background: Whether retinal microglia can maintain or restore immune homeostasis during and after inflammation is unclear. We performed single-eye mRNA-sequencing on microglia at different timepoints following a single inflammatory stimulus...

Family and community resilience: a Photovoice study

Abstract Background Adverse childhood experiences (ACEs), in combination with adverse community environments, can result in traumatic stress reactions, increasing a person’s risk for chronic physical and mental health conditions. Family res...

Microenvironment‐adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm‐associated diabetic chronic wound healing cascade

Abstract The presence of bacterial biofilms and the occurrence of excessive inflammatory response greatly imped the healing process of chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues...

Research on Personalized Recommendation Algorithm Integrating Cross-Grained Sentiment and Rating Interaction Features

To investigate the impact of cross-grained sentiments on user feature representation and address the issue of data sparsity, this paper proposes a Personalized Recommendation Algorithm Integrating Cross-Grained Sentiment and Rating Interact...

Assembly Function Recognition in Embedded Systems as an Optimization Problem

Many different aspects of software system development and verification rely on precise function identification in binary code. Recognition of the source Assembly functions in embedded systems is one of the fundamental challenges in binary p...

Reliability Model Based Dynamic Multi-Level Trust Analysis

Trust assessment is of great significance to related issues such as privacy protection and rumor transmission in online social networks. At present, there are mainly two types of trust models: discrete type and continuous, type. Little work...

Technology-Supported Behavior Change—Applying Design Thinking to mHealth Application Development

Non-communicable diseases are the leading cause of global deaths. The risk of their development and progression is increased by modifiable behavioral risk factors. Yet, despite the known benefits of primary and secondary prevention, people ...

Optimization of Support and Relief Parameters for Deep-Buried Metal Mine Roadways

The management of rock mass deformation in high-stress roadways is a pivotal aspect of deep geotechnical engineering. Given the fruitful outcomes of research in rock mechanics regarding traditional confining pressure control methods, schola...

Effects of bystander interventions on school bullying: a systematic review and meta-analysis.

Analysing interventions designed to reduce tuberculosis-related stigma: A scoping review.

Stigma is a critical barrier for TB care delivery; yet data on stigma reduction interventions is limited. This review maps the available literature on TB stigma reduction interventions, using the Health Stigma and Discrimination framework a...

Views of generation Z nurse candidates on their willingness to work in featured services in hospitals: A qualitative study

The aim of this study is to identify the willingness of generation Z nursing students to work in the specialized units, as well as their views about these units, and to find answers to issues such as which units they want to work in and why...

Approaches, challenges, and recommendations for clinical practice in gestational syphilis: a scoping review

ABSTRACT Objective to map the scientific evidence on the approach to gestational syphilis, the sociodemographic profile of pregnant women, and the challenges related to its management and follow-up. Method scoping review carried out in Oc...