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A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil

Maria Luiza Lima-Silva, Karen Cecília Lima Torres, Juliana Vaz de Melo Mambrini, Nathalia Coimbra Brot et al. • Experimental Gerontology (2024)

Immunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as “Inflammaging.” Inflammaging can be associated with many dis...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2024.112433

Anti-Amnesic Effects of Epigallocatechin Gallate on Scopolamine-Induced Learning and Memory Dysfunction in Sprague-Dawley Rats

Min-Jeong Kim, Eun-Sang Hwang, Kwan Joong Kim, Sungho Maeng et al. • Antioxidants (2021)

Epigallocatechin gallate (EGCG) is a major flavan-3-ol of green tea polyphenols that exhibits various beneficial health effects, including antioxidant, anti-bacterial, and anti-inflammatory properties. This study aimed to evaluate whether E...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox11010001

Correlation between sarcopenia and changes in oligodendrocyte lineage cells in the brains of Alzheimer's disease model mice

Lin-lin Yao, Xiao-ting Ma, Fang-bo Li, Lin-yi Zheng et al. • Experimental Gerontology (2026)

Background: Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by cognitive dysfunction. The discovery and identification of non-cognitive symptoms in the preclinical stage hold promise for early diagnosis and ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2026.113057

Discharge preparation experiences of intergenerational caregivers for premature infants in China’s NICU: a qualitative study

Yan Zhang, Ling Jiang, Jinyu Zhu, Sijia Shen et al. • BMJ Paediatrics Open (2026)

Background Proper discharge preparation by family caregivers is essential for improving the growth and development of preterm infants and lowering their readmission rates. Within China’s unique family cultural context, intergenerational car...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjpo-2026-004695 PMC: PMC13691880

Equipment in Senior Gyms: Influence on the Behavior of Blood Pressure and Heart Rate of Elderlies

Sillas Oliveira Leonel Júnior, Mateus Dias Antunes, Ramon Gustavo de Moraes Ovando, Ana Paula Serra de Araújo et al. • Geriatrics, Gerontology and Aging (2024)

OBJECTIVE: To analyze the behavior of blood pressure and heart rate in elderly people practicing physical exercises in Maringá, Paraná, Brazil. METHODS: 70 elderly volunteers were evaluated, 41 women and 29 men, with a mean age of 67.2 ± 6....

DOAJ Open Access (DOAJ) DOI: 10.5327/Z2447-211520171700042

Rare genetic diseases associated with G-quadruplex-induced replication stress

Lauren M. Herr, Swagata Mukhopadhyay, Olivia M. Anderson, Tucker H. Couch et al. • Communications Biology (2026)

Abstract DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substant...

DOAJ Open Access (DOAJ) DOI: 10.1038/s42003-026-09966-4

Higher calorie intake with adequate exercise is associated with reduced mortality compared with low-calorie diet with equivalent exercise: An observational study from NHANES based on the 2020–2025 Dietary Guidelines for Americans

Hanghang Gan, Yu Yan, Shanshan Jia, Yingqiang Guo et al. • Experimental Gerontology (2025)

Object: To explore the effects of different combinations of calorie intake and exercise on all-cause, cardiovascular and cancer mortality. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weigh...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.112805

Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics

Junqi Yang, Yumin Ma, Jiang Liu, Qingtian Zhu et al. • Experimental Gerontology (2024)

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cel...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2024.112633

Effectiveness of music-based interventions in acute care settings for people living with dementia to reduce anxiety and enhance the care experience: A systematic review.

Victoria McArthur, Susan Everington, Martyn Patel • Archives of Gerontology and Geriatrics Plus (2024)

Introduction: Dementia is a global health priority, with an increasing percentage of overall hospital bed days occupied by people with dementia (PWD). This combined with increased demand and availability of complex scanning means that there...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aggp.2024.100087

Linking Spiritual and Religious Coping With the Quality of Life of Community-Dwelling Older Adults and Nursing Home Residents

Luciano Magalhães Vitorino BSN, MSc, Gail Low RN, BSN, MA, PhD, Lucila Amaral Carneiro Vianna PhD • Gerontology and Geriatric Medicine (2016)

Objective: This study examined the effect of Positive and Negative Spiritual and Religious Coping (SRC) upon older Brazilian’s quality of life (QOL). Method: A secondary analysis of data collected from 77 nursing home residents (NHRs; M age...

DOAJ Open Access (DOAJ) DOI: 10.1177/2333721416658140

Impact of age-friendly living environment and intrinsic capacity on functional ability in older adults: a cross-sectional study

Yi-Shan Jiang, Hong Shi, Yu-Ting Kang, Ji Shen et al. • BMC Geriatrics (2023)

Abstract Background The World Health Organization (WHO) has proposed healthy aging framework, supposing that intrinsic capacity (IC), environment and their interaction may have influence on functional ability (FA). It was still unclear how ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-04089-5

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

Eimear Connolly, Shane Lyons, Cliona O’Farrelly, Graham Knight et al. • BMJ Open (2023)

Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the un...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2023-077772

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults

Yan Zhao, Tingting Chen, Conghua Ji, Yuxin Shang et al. • Experimental Gerontology (2026)

Background: Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.113010

Creating Exercise Spaces in Parks for Older Adults With Fitness, Rehabilitation, and Play Elements: A Review and Perspective

Janet Lok Chun Lee, Rainbow Tin Hung Ho • Gerontology and Geriatric Medicine (2022)

Parks usually create a protective playground space for children to perform physical activity like jumping, running, and climbing. Specific spaces have rarely been created for older adults to perform physical activity in public parks. Now th...

DOAJ Open Access (DOAJ) DOI: 10.1177/23337214221083404

The interplay of risk factors for future falls and fall-related injuries among community-dwelling older adults: a Bayesian network analysis

Yan Cai, Wei Zhu, Chenshu Wu, Yan Jiang • BMC Public Health (2026)

Abstract Background Falls are a leading global cause of injury and mortality in older adults, necessitating understanding risk factor interplay for prevention. This study aims to investigate complex interactions among risk factors associate...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12889-026-27192-9

Watching Out for Older Drivers

Samuel Durso • MedEdPORTAL (2006)

Abstract Motor vehicle accidents are the leading cause of injury-related deaths among adults age 65 to 74. This risk for traffic fatalities may triple as the numbers of older drivers increases in the coming years. It is the ethical opinion ...

DOAJ Open Access (DOAJ) DOI: 10.15766/mep_2374-8265.194

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease

Erden Eren, Jeannie-Marie Leoutsakos, Juan Troncoso, Constantine G. Lyketsos et al. • Cells (2022)

The hallmarks of Alzheimer’s disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanism...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells11030436

Heterogeneity in Trajectories of Body Mass Index and Their Associations with Mortality in Old Age: A Literature Review

Hiroshi Murayama, Benjamin A. Shaw • Journal of Obesity & Metabolic Syndrome (2017)

This article reviewed studies to investigate the association between trajectories of body mass index (BMI) and mortality among older adults. Investigators conducted a systematic search of published peer-reviewed literature in the PubMed dat...

DOAJ Open Access (DOAJ) DOI: 10.7570/jomes.2017.26.3.181

Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease

Anum Zahra, Maarten van Smeden, Petra J. M. Elders, Jan Festen et al. • BMC Geriatrics (2025)

Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vul...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-025-05721-2

Association between Postoperative Neck Pain and Intraoperative Transcranial Motor-Evoked Potential Waveforms of the Trapezius Muscles in Patients with Cervical Myelopathy Who Underwent Cervical Laminoplasty

Sadayuki Ito, Yoshihito Sakai, Kei Ando, Hiroaki Nakashima et al. • Asian Spine Journal (2023)

Study Design Retrospective study. Purpose Cervical laminoplasty is safe and effective for treating cervical myelopathy but has a higher frequency of postoperative axial pain compared to other methods. Several studies have reported on the ca...

DOAJ Open Access (DOAJ) DOI: 10.31616/asj.2022.0120