Academic Articles & Research Papers

Knockout of

Direct-seeded rice (DSR) offers a sustainable alternative for climate-resilient agriculture, but it is severely threatened by the root-knot nematode Meloidogyne graminicola . Knockout of susceptibility (S) genes has emerged as a promising s...

How <i>Phytophthora</i> Effectors Disrupt Post-Translational Regulation in Plant Immunity: Canonical and Non-Canonical Mechanisms

Plant–pathogen interactions are shaped by dynamic regulatory processes that control immune signaling. Among these, post-translational modifications (PTMs) play central roles in modulating protein activity, stability, and interaction network...

FSP1 as the convergent hub of autophagy and ubiquitination governing ferroptosis in monocrotaline-induced pulmonary arterial hypertension.

Axial Function Reflects Global Severity in Inherited Ataxias: The Upright Stability Score in Ambulatory Friedreich vs. Spinocerebellar Ataxia.

PRIMUS: Comprehensive proteomics of mouse intervertebral discs that inform novel biology and relevance to human disease modelling

Mice are commonly used to study intervertebral disc (IVD) biology and related diseases such as IVD degeneration. Discs from both the lumbar and tail regions are used. However, little is known about compartmental characteristics in the diffe...

Piezo1 knockdown activates PI3K/AKT and enhances SPP1 to drive M2 macrophage polarization and reduce cardiac inflammation

Abstract Piezo1 plays a key role in the immune response during sepsis. To date, our understanding of the role of Piezo1 in inflammatory diseases has mostly been limited to influencing vasomotor function and regulating inflammatory infiltrat...

Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes

Abstract Background Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1) and its m...

Induced Pluripotent Stem Cells (iPSCs)—Roles in Regenerative Therapies, Disease Modelling and Drug Screening

The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution to the field of regenerative medicine, paving way for identifying the true potential of human embryonic stem cells (ESCs). Since the controversy aro...

Metabolomic Profile Alterations Associated with the SLC16A11 Risk Haplotype Following a Lifestyle Intervention in People With Prediabetes

Background: A risk haplotype in SLC16A11 characterized by alterations in fatty acid metabolism emerged as a genetic risk factor associated with increased susceptibility to type 2 diabetes (T2D) in Mexican population. Its role on treatment r...

C3a Enhances the Formation of Intestinal Organoids through C3aR1

C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied....

Single Eye mRNA-Seq Reveals Normalisation of the Retinal Microglial Transcriptome Following Acute Inflammation

Background: Whether retinal microglia can maintain or restore immune homeostasis during and after inflammation is unclear. We performed single-eye mRNA-sequencing on microglia at different timepoints following a single inflammatory stimulus...

Microenvironment‐adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm‐associated diabetic chronic wound healing cascade

Abstract The presence of bacterial biofilms and the occurrence of excessive inflammatory response greatly imped the healing process of chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues...

Management of Ureters Involved in Inguinal Hernias

Background: The presence of a ureter in a hernia sac presents a unique surgical challenge and can increase the likelihood of ureteral injury at the time of surgery as they are often not identified pre-operatively. Here we present our instit...

Artificial intelligence in clinical medicine: a state-of-the-art overview of systematic reviews with methodological recommendations for improved reporting

Medicine has become increasingly receptive to the use of artificial intelligence (AI). This overview of systematic reviews (SRs) aims to categorise current evidence about it and identify the current methodological state of the art in the fi...

Knowledge and natural language processing

KBNL is a knowledge-based natural language processing system that is novel in several ways, including the clean separation it enforces between linguistic knowledge and world knowledge, and its use of knowledge to aid in lexical acquisition....

Bias and Fairness in Natural Language Processing

Recent advances in data-driven machine learning techniques (e.g., deep neural networks) have revolutionized many natural language processing applications. These approaches automatically learn how to make decisions based on the statistics an...

Enhancing sentiment classification on small datasets through data augmentation and transfer learning

Abstract Small-scale sentiment classification often suffers from data scarcity, which limits the generalization ability of the models. This study evaluates and compares the effectiveness of three data augmentation strategies: Easy Data Augm...

Evolution of transfer learning in natural language processing

In this paper, we present a study of the recent advancements which have helped bring Transfer Learning to NLP through the use of semi-supervised training. We discuss cutting-edge methods and architectures such as BERT, GPT, ELMo, ULMFit amo...

On Application of Natural Language Processing in Machine Translation

Natural language processing is the core of machine translation. In the history, its development process is almost the same as machine translation, and the two complement each other. This article compares the natural language processing of s...

Policy consensus, disagreements, and gaps regarding the use of artificial intelligence in authors, reviewers, publishers, editors, readers, and scholarship dissemination: a narrative review focus on medical scholarly publishing, analyzing attitudes of 6 institutions, 8 publishers, 139 journals and hundreds of articles.