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The Vibrio vulnificus stressosome is an oxygen-sensor involved in regulating iron metabolism

Veronika Heinz, Wenke Jäckel, Susann Kaltwasser, Laura Cutugno et al. • Communications Biology (2022)

A cryo-electron microscopy reconstruction of a stressosome complex from a Gram-negative bacterium, Vibrio vulnificus, reveals variations in subunit composition and symmetry, which could serve to adjust the activation threshold in the respon...

DOAJ Open Access (DOAJ) DOI: 10.1038/s42003-022-03548-w

Application of a novel pH-responsive gemini surfactant for delivery of curcumin molecules

Maral Rahimzadeh, Majid Sadeghizadeh, Farhood Najafi, Seyed Shahriar Arab et al. • Materials Research Express (2020)

During the last few decades, extensive studies have been conducted to elucidate the anti-cancer effects of curcumin. Despite promising results indicating curcumin could impede cancer cells ability thrive and proliferation, clinical applicat...

DOAJ Open Access (DOAJ) DOI: 10.1088/2053-1591/ab770f

Roles of Rap1 signaling in tumor cell migration and invasion

Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring et al. • Cancer Biology & Medicine (2017)

Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Th...

DOAJ Open Access (DOAJ) DOI: 10.20892/j.issn.2095-3941.2016.0086

In vivo topology converts competition for cell-matrix adhesion into directional migration

Fernanda Bajanca, Nadège Gouignard, Charlotte Colle, Maddy Parsons et al. • Nature Communications (2019)

Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-019-09548-5

Total mercury exposure in early pregnancy has no adverse association with scholastic ability of the offspring particularly if the mother eats fish

Joseph Hibbeln, Steven Gregory, Yasmin Iles-Caven, Caroline M. Taylor et al. • Environment International (2018)

There is a public perception that relatively low doses of mercury found in seafood are harmful to the fetal brain but little consistent evidence to support this. In earlier publications we have shown no adverse associations between maternal...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.envint.2018.03.024

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V Variants

Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw et al. • Cells (2026)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 di...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells15040342

Dielectric Properties of Phosphatidylcholine Membranes and the Effect of Sugars

Victoria Vitkova, Vesela Yordanova, Galya Staneva, Ognyan Petkov et al. • Membranes (2021)

Simple carbohydrates are associated with the enhanced risk of cardiovascular disease and adverse changes in lipoproteins in the organism. Conversely, sugars are known to exert a stabilizing effect on biological membranes, and this effect is...

DOAJ Open Access (DOAJ) DOI: 10.3390/membranes11110847

<i>Vegfr3</i> and <i>Tbx1</i> Interact in Cardiac Morphogenesis

Stefania Martucciello, Marchesa Bilio, Sara Cioffi, Ilaria Aurigemma et al. • Journal of Cardiovascular Development and Disease (2026)

Gene inactivation in model organisms has identified numerous genes and signaling pathways involved in mammalian cardiac outflow tract (OFT) development. Human genetics data have implicated the VEGFR3 gene in OFT development, but when and wh...

DOAJ Open Access (DOAJ) DOI: 10.3390/jcdd13080399

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods (2025)

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14234030

Clinical evaluation of DIAGNOVIR SARS-CoV-2 ultra-rapid antigen test performance compared to PCR-based testing

Ali Aytac Seymen, Ezgi Gulten, Erol Ozgur, Bülend Ortaç et al. • Scientific Reports (2023)

Abstract Coronavirus Disease-19 (COVID-19) is a highly contagious infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The development of rapid antigen tests has contributed to easing the burden on ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-023-31177-8

Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative

Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares et al. • Molecules (2021)

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural mod...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules26226923

Nucleotide-binding oligomerization domain protein-1 is expressed and involved in the inflammatory response in human sebocytes

Natsuko Kitajima, Takahisa Nakajo, Takeshi Katayoshi, Kentaro Tsuji-Naito • Biochemistry and Biophysics Reports (2023)

Sebocytes express Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), which participate in the innate immune response of the skin. Although the roles of TLRs and NLR family pyrin domain-cont...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.bbrep.2023.101561

Pairwise Performance Comparison of Docking Scoring Functions: Computational Approach Using InterCriteria Analysis

Maria Angelova, Petko Alov, Ivanka Tsakovska, Dessislava Jereva et al. • Molecules (2025)

Scoring functions are key elements in docking protocols as they approximate the binding affinity of a ligand (usually a small bioactive molecule) by calculating its interaction energy with a biomacromolecule (usually a protein). In this stu...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules30132777

Dependence of Freeze-Out Parameters on Collision Energies and Cross-Sections

Muhammad Waqas, Atef AbdelKader, Muhammad Ajaz, Abdel Nasser Tawfik et al. • Universe (2023)

We analyzed the transverse momentum spectra (pT) reported by the NA61/SHINE and NA49 experiments in inelastic proton–proton (pp) and central Lead–Lead (Pb−Pb), Argon–Scandium (Ar−Sc), and Beryllium–Beryllium (Be−Be) collisions with the Blas...

DOAJ Open Access (DOAJ) DOI: 10.3390/universe9010044

Additive roles of antiferromagnetically coupled elements in the magnetic proximity effect in the GdFeCo/Pt system

Jung Yun Kee, Kook Tae Kim, In Hak Lee, Ilwan Seo et al. • Scientific Reports (2024)

Abstract Interfacial magnetic interactions between different elements are the origin of various spin-transport phenomena in multi-elemental magnetic systems. We investigate the coupling between the magnetic moments of the rare-earth, transi...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-024-60076-9

All-dielectric metaoptics for the compact generation of double-ring perfect vector beams

Vogliardi Andrea, Ruffato Gianluca, Bonaldo Daniele, Dal Zilio Simone et al. • Nanophotonics (2023)

Perfect vortices, whose ring profile is independent of the topological charge, play a key role in telecommunications and particle micro-manipulation. In this work, we report the compact generation of a new kind of double-ring perfect vortic...

DOAJ Open Access (DOAJ) DOI: 10.1515/nanoph-2023-0555