Academic Articles & Research Papers

An Integrated Approach for Designing and Analyzing Lumbar Vertebral Biomodels with Artificial Disc Replacement

This study aims to develop an integrated approach for 3D lumbar vertebral biomodel design and analysis, specifically targeting unilevel disc degeneration and the replacement of lumbar artificial discs. Key objectives include improving exist...

Examining Rural and Urban Sentiment Difference in COVID-19–Related Topics on Twitter: Word Embedding–Based Retrospective Study

BackgroundBy the end of 2022, more than 100 million people were infected with COVID-19 in the United States, and the cumulative death rate in rural areas (383.5/100,000) was much higher than in urban areas (280.1/100,000). As the pandemic s...

Identification of brain regions predicting epileptogenesis by serial [18F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy

Excessive activation of inflammatory signaling pathways seems to be a hallmark of epileptogenesis. Positron emission tomography (PET) allows in vivo detection of brain inflammation with spatial information and opportunities for longitudinal...

Correction: Potential Correlates of Internet Gaming Disorder Among Indonesian Medical Students: Cross-sectional Study

Multidetector Computed Tomography (MDCT) Findings of Complications of Acute Cholecystitis. A Pictorial Essay

Acute cholecystitis stands out as one of the most common surgical pathologies that should always be considered in a right-upper abdominal pain emergency. For this, the importance of a correct diagnosis is well described. However, it has bee...

Medical informaticsʼ promised land

A decade ago, a "promised land" was envisioned in which the true potential of medical informatics would be realized. A decade later, it is time to assess academic medicine's progress in its journey into this medical informatics promised lan...

Section IV. Medical Informatics

WHAT IS IT? In the summer of 2004 I was invited to lecture at Dartmouth. Dr. Rosen, my host,asked me if I could address my interpretation of Medical Informatics during my lecture. Thispresentation made me review and reflect on some old and ...

Penetration and familiarity of false belief on neuroscience among students and its modifiability

In Study 1, the degrees of penetration and familiarity of false belief on neuroscience, especially brain imaging, among students were surveyed using a questionnaire technique. A total number of 485 students from medical school, school of nu...

Datasets describing hydrogel properties and cellular metrics for modeling of tumor dormancy

Breast cancer dormancy is an underlying challenge toward targeting and controlling metastatic recurrence and disease progression. Development of engineered, well-defined in vitro models is necessary to systematically recapitulate tumor dorm...

From Connectivity to Controllability: Unraveling the Brain Biomarkers of Major Depressive Disorder

Major Depressive Disorder (MDD) is a significant neurological condition associated with aberrations in brain functional networks. Traditional studies have predominantly analyzed these from a network topology perspective. However, given the ...

Accelerated maximum likelihood parameter estimation for stochastic biochemical systems

Abstract Background A prerequisite for the mechanistic simulation of a biochemical system is detailed knowledge of its kinetic parameters. Despite recent experimental advances, the estimation of unknown parameter values from observed data i...

Swarm v2: highly-scalable and high-resolution amplicon clustering

Previously we presented Swarm v1, a novel and open source amplicon clustering program that produced fine-scale molecular operational taxonomic units (OTUs), free of arbitrary global clustering thresholds and input-order dependency. Swarm v1...

Functional neuroimaging of visuospatial working memory tasks enables accurate detection of attention deficit and hyperactivity disorder

Finding neurobiological markers for neurodevelopmental disorders, such as attention deficit and hyperactivity disorder (ADHD), is a major objective of clinicians and neuroscientists. We examined if functional Magnetic Resonance Imaging (fMR...

BirdsEyeView (BEV): graphical overviews of experimental data

Abstract Background Analyzing global experimental data can be tedious and time-consuming. Thus, helping biologists see results as quickly and easily as possible can facilitate biological research, and is the purpose of the software we descr...

The role of medical informatics in the management of medical information

With progress in information and communication technology, medical information has been converted to digital formats and stored and managed using computer systems. The construction, management, and operation of medical information systems a...

Evolution of medical informatics in bibliographic databases

Medical informatics became a medical specialty during the last years and this is evidenced by a great amount of journal articles regarding the subject published worldwide. We compared the presentation of Medical Informatics in two different...

Impacts of the COVID-19 Pandemic on Primary Care Utilization: An Analysis of Primary Care Claims Data in Alberta, Canada

Background: The COVID-19 pandemic disrupted primary health care systems worldwide, prompting rapid changes in how care was delivered. In Alberta, this included a significant shift from in-person to virtual care. This study examines trends i...

In silico analysis of ciprofloxacin analogs as inhibitors of DNA gyrase of Staphylococcus aureus

In this in silico study, thirty-five ciprofloxacin analogs were docked to the active site of DNA gyrase, the prime target of ciprofloxacin type antibiotics. Prior to docking all the structures were optimized using MM2 force field parameters...

Brain perfusion imaging in neonates

Abnormal variations of the neonatal brain perfusion can result in long-term neurodevelopmental consequences and cerebral perfusion imaging can play an important role in diagnostic and therapeutic decision-making. To identify at-risk situati...

Modulation of frontal gamma oscillations improves working memory in schizophrenia

Schizophrenia is a debilitating mental disorder that is associated with cognitive deficits. Impairments in cognition occur early in the course of illness and are associated with poor functional outcome, but have been difficult to treat with...