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Piezo1 knockdown activates PI3K/AKT and enhances SPP1 to drive M2 macrophage polarization and reduce cardiac inflammation

Yunhan Zhang, Ying Zhang, Jiaoyan Song, Ziwen Zhao et al. • Scientific Reports (2026)

Abstract Piezo1 plays a key role in the immune response during sepsis. To date, our understanding of the role of Piezo1 in inflammatory diseases has mostly been limited to influencing vasomotor function and regulating inflammatory infiltrat...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-34794-7

Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes

Annie Cristhine Moraes Sousa-Squiavinato, Renata Ivo Vasconcelos, Adriana Sartorio Gehren, Priscila Valverde Fernandes et al. • Cancer Cell International (2021)

Abstract Background Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1) and its m...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12935-021-01770-w

Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico Analysis

Chinmay Saha, Sayantan Laha, Raghunath Chatterjee, Nitai P. Bhattacharyya • Non-Coding RNA (2021)

Altered expression of protein coding gene (PCG) and long non-coding RNA (lncRNA) have been identified in SARS-CoV-2 infected cells and tissues from COVID-19 patients. The functional role and mechanism (s) of transcriptional regulation of de...

DOAJ Open Access (DOAJ) DOI: 10.3390/ncrna7040074

UTRme: A Scoring-Based Tool to Annotate Untranslated Regions in Trypanosomatid Genomes

Santiago Radío, Santiago Radío, Rafael Sebastián Fort, Rafael Sebastián Fort et al. • Frontiers in Genetics (2018)

Most signals involved in post-transcriptional regulatory networks are located in the untranslated regions (UTRs) of the mRNAs. Therefore, to deepen our understanding of gene expression regulation, delimitation of these regions with high acc...

DOAJ Open Access (DOAJ) DOI: 10.3389/fgene.2018.00671

Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair

Mahmoud Balata, Mohamed Ibrahim Gbreel, Mohamed Hamouda Elkasaby, Marwa Hassan et al. • Journal of Cardiothoracic Surgery (2025)

Abstract Background Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. We aim to co...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13019-024-03218-4

Genetic Markers of Adaptation of <named-content content-type="genus-species">Plasmodium falciparum</named-content> to Transmission by American Vectors Identified in the Genomes of Parasites from Haiti and South America

Massimiliano S. Tagliamonte, Charles A. Yowell, Maha A. Elbadry, Jacques Boncy et al. • mSphere (2020)

ABSTRACT The malaria parasite, Plasmodium falciparum, was introduced into Hispaniola and other regions of the Americas through the slave trade spanning the 16th through the 19th centuries. During this period, more than 12 million Africans w...

DOAJ Open Access (DOAJ) DOI: 10.1128/mSphere.00937-20

Single Eye mRNA-Seq Reveals Normalisation of the Retinal Microglial Transcriptome Following Acute Inflammation

Oliver H. Bell, David A. Copland, Amy Ward, Lindsay B. Nicholson et al. • Frontiers in Immunology (2020)

Background: Whether retinal microglia can maintain or restore immune homeostasis during and after inflammation is unclear. We performed single-eye mRNA-sequencing on microglia at different timepoints following a single inflammatory stimulus...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2019.03033

Exploring innovation landscapes: a national cross-sectional study of Swedish primary care from the viewpoint of primary care managers

Sarah Samuelson, Eva-Lisa Petersson, Cecilia Björkelund, Marcus Praetorius Björk et al. • BMC Health Services Research (2026)

Abstract Background Innovation is increasingly necessary in primary care policy, and healthcare managers play a pivotal role in translating policy ambitions into practice and shaping organisational conditions that foster innovation. The aim...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12913-026-14870-y

Small Object Detection Algorithm Based on Improved YOLOv8 for Remote Sensing

Hao Yi, Bo Liu, Bin Zhao, Enhai Liu • IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2024)

Due to the limitations of small targets in remote sensing images, such as background noise, poor information, and so on, the results of commonly used detection algorithms in small target detection is not satisfactory. To improve the accurac...

DOAJ Open Access (DOAJ) DOI: 10.1109/JSTARS.2023.3339235

Motion-Compensated PET Image Reconstruction via Separable Parabolic Surrogates

Nicholas E. Protonotarios, George A. Kastis, Andreas D. Fotopoulos, Andreas G. Tzakos et al. • Mathematics (2022)

The effective resolution of positron emission tomography (PET) can be significantly degraded by patient motion during data acquisition. This is especially true in the thorax due to respiratory motion. This study concentrates on the improvem...

DOAJ Open Access (DOAJ) DOI: 10.3390/math11010055

Improving the Transferability of Suspended Solid Estimation in Wetland and Deltaic Waters with an Empirical Hyperspectral Approach

Daniel Jensen, Marc Simard, Kyle Cavanaugh, Yongwei Sheng et al. • Remote Sensing (2019)

The deposition of suspended sediment is an important process that helps wetlands accrete surface material and maintain elevation in the face of sea level rise. Optical remote sensing is often employed to map total suspended solids (TSS), th...

DOAJ Open Access (DOAJ) DOI: 10.3390/rs11131629

Research on Personalized Recommendation Algorithm Integrating Cross-Grained Sentiment and Rating Interaction Features

Bing Li, Jiangtao Dong, Xile Wang, Yuqi Hou et al. • IEEE Access (2025)

To investigate the impact of cross-grained sentiments on user feature representation and address the issue of data sparsity, this paper proposes a Personalized Recommendation Algorithm Integrating Cross-Grained Sentiment and Rating Interact...

DOAJ Open Access (DOAJ) DOI: 10.1109/ACCESS.2025.3530431

A Novel Depression Rehabilitation Game Framework Using VR Based on Neurofeedback

CAI Hanshu,WANG Ziyang,ZHANG Yanhao,CHEN Yunfei,HU Bi • Jisuanji gongcheng (2018)

At present,depression is treated with antidepressant drugs and assisted with psychotherapy and physical therapy,and these expensive and time-consuming treatment methods often end prematurely and result in a prolonged course without effectiv...

DOAJ Open Access (DOAJ) DOI: 10.19678/j.issn.1000-3428.0050904

Proposing New Data Whitening Method through Application of LSTM Method for Fault Condition Prediction in Bearing Data

Nasrin Rezaei, Andreas Rehkopf • Advances in Engineering and Intelligence Systems (2026)

In the context of big data, data preprocessing, especially data whitening, plays a pivotal role in improving the effectiveness of AI models. While traditional whitening methods suffer from severe computational bottlenecks, arising from the ...

DOAJ Open Access (DOAJ) DOI: 10.22034/aeis.2026.575941.1510

Analysing interventions designed to reduce tuberculosis-related stigma: A scoping review.

Isabel Foster, Michelle Galloway, Wieda Human, Michaile Anthony et al. • PLOS Global Public Health (2022)

Stigma is a critical barrier for TB care delivery; yet data on stigma reduction interventions is limited. This review maps the available literature on TB stigma reduction interventions, using the Health Stigma and Discrimination framework a...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pgph.0000989