Reset
Showing 20 of 7,962 academic articles

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja, Emily Symington et al. • Research and Practice in Thrombosis and Haemostasis (2024)

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection. Objectives: Determine valoctocogene roxaparvovec du...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rpth.2024.102615

EFFECT OF VITAMIN A ON CYCLOSPORINE NEPHROTOXICITY IN UNINEPHRECTOMIZED RATS

Hoda Mohamed, Hazar Yacoub, Heba Ameen, Dureah Sebah • Zagazig Journal of Pharmaceutical Sciences (1997)

The influence of vitamin A (1.5 mg kg-1 body weight) administration for two weeks on cyclosporine A (CsA, 25 mg kg-1 body weight) induced renal dysfunction has been investigated in uninephrectomized and sham nephrectomized rats. Single kidn...

DOAJ Open Access (DOAJ) DOI: https://doi.org/10.21608/zjps.1997.184951

Molecular Dynamics and In Vitro Studies Elucidating the Tunable Features of Reconfigurable Nanodiscs for Guiding the Optimal Design of Curcumin Formulation

Yongxiao Li, Wanting Xu, Xinpei Wang, Ruizhi Lai et al. • Bioengineering (2024)

In this study, we advance our exploration of Apolipoprotein A-I (apoA-I) peptide analogs (APAs) for their application in nanodisc (ND) assembly, focusing on the dynamic conformational characteristics and the potential for drug delivery. We ...

DOAJ Open Access (DOAJ) DOI: 10.3390/bioengineering11030245

Perspective on the Therapeutics of Anti-Snake Venom

Isabel Gómez-Betancur, Vedanjali Gogineni, Andrea Salazar-Ospina, Francisco León • Molecules (2019)

Snakebite envenomation is a life-threatening disease that was recently re-included as a neglected tropical disease (NTD), affecting millions of people in tropical and subtropical areas of the world. Improvement in the therapeutic approaches...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules24183276

Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades

Xinpeng Jiang, Shanshan Gu, Di Liu, Lili Zhao et al. • Frontiers in Microbiology (2018)

Aims:Lactobacillus strains have protective effects against heavy metals while relieving oxidative stress and modulating the immune response. Mechanisms that ameliorate heavy metal toxicity and the relationship between probiotics and gut bar...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.02425

Role of pyroptosis in spinal cord injury and its therapeutic implications

Abdullah Al Mamun, Yanqing Wu, Ilma Monalisa, Chang Jia et al. • Journal of Advanced Research (2021)

Background: Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jare.2020.08.004

Enteric Coating Enhances the Biopharmaceutical Performance of a Silica–Lipid Formulation of Abiraterone Acetate

Ali Taheri, Ruba Almasri, Anthony Wignall, Felicia Feltrin et al. • Pharmaceutics (2025)

Background/Objectives: Lipid-based formulations are widely used to enhance the oral bioavailability of poorly water-soluble drugs. However, for weakly basic drugs with higher solubility under acidic conditions, precipitation and recrystalli...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics17101289

Characterization of low-nitrogen quantum diamond for pulsed magnetometry applications

Jiashen Tang, Jiashen Tang, Connor A. Roncaioli, Andrew M. Edmonds et al. • Frontiers in Quantum Science and Technology (2025)

Ensembles of nitrogen-vacancy (NV) centers in diamond are versatile quantum sensors with broad applications in the physical and life sciences. The concentration of neutral substitutional nitrogen ([Ns0]) strongly influences NV electronic sp...

DOAJ Open Access (DOAJ) DOI: 10.3389/frqst.2025.1701548

Synthesis of ultra‐high molecular weight core cross‐linked star (CCS) polymer using high molecular weight spherical nanoparticles and arm‐first method

Guangyao Liu, Yongqi Yang, Chao Zheng, Xiaoqun Cao • Nano Select (2022)

Abstract P (N,N‐Dimethylacrylamide) ‐b‐P (2‐methoxyethyl acrylate) (PDMA‐b‐PMEA) and Poly (poly (ethylene glycol) methyl ether methacrylate) ‐b‐P (2‐methoxyethyl acrylate) (PPEGMA‐b‐PMEA) di‐block copolymer nanoparticles are prepared by RAF...

DOAJ Open Access (DOAJ) DOI: 10.1002/nano.202100216

Modulation Instability and Abundant Exact Solitons to the Fractional Mathematical Physics Model Through Two Distinct Methods

Abdulaziz Khalid Alsharidi, Ahmet Bekir • Axioms (2025)

The paper consists of various types of wave solutions for the truncated M-fractional Bateman–Burgers equation, a significant mathematical physics equation. This model describes the nonlinear waves and solitons in different physical fields s...

DOAJ Open Access (DOAJ) DOI: 10.3390/axioms14080617

Controlled Plasmonic Coupling in Silver Nanoplate Dimers for Enhanced Plasmonic Sensing

Lucrezia Catanzaro, Marcello Condorelli, Mario Pulvirenti, Luisa D’urso et al. • Nanomaterials (2026)

Noble metal nanostructures provide versatile platforms for light manipulation through localized surface plasmon resonances (LSPRs). Among them, triangular silver nanoplates (AgNPTs) exhibit strong field-enhancement and spectral tunability, ...

DOAJ Open Access (DOAJ) DOI: 10.3390/nano16080486

Ultra-Bend-Resistant 4-Core Simplex Cable Used for Short-Reach Dense Spatial Division Multiplexing Optical Transmission

Zelin Zhang, Yu Qin, Jie Zhu, Caoyuan Wang et al. • Micromachines (2024)

We optimized and fabricated an ultra-bend-resistant 4-core simplex cable (SXC) employing 4-core multicore fiber (MCF) suitable for short-reach dense spatial division multiplexing (DSDM) optical transmission in the O-band. The characteristic...

DOAJ Open Access (DOAJ) DOI: 10.3390/mi15010108

Imaging with Diffractive Axicons Rapidly Milled on Sapphire by Femtosecond Laser Ablation

Daniel Smith, Soon Hock Ng, Molong Han, Tomas Katkus et al. • Engineering Proceedings (2023)

We show that single-pulse burst fabrication will produce a flatter and smoother profile of axicons milled on sapphire compared to pulse overlapped fabrication which results in a damaged and much rougher surface. The fabrication of large-are...

DOAJ Open Access (DOAJ) DOI: 10.3390/HMAM2-14147

Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI)

Zhenyue Chen, Yi Chen, Irmak Gezginer, Qingxiang Ding et al. • Light: Science & Applications (2025)

Abstract A critical gap currently exists in systematic understanding and experimental validation of the role of astrocytes in neurovascular coupling and their functional links with other brain cells. Despite a broad selection of functional ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41377-025-02003-9

Photovoltaic Performance of Pin Junction Nanocone Array Solar Cells with Enhanced Effective Optical Absorption

Jinnan Zhang, Lingmei Ai, Xin Yan, Yao Wu et al. • Nanoscale Research Letters (2018)

Abstract The photovoltaic performance of axial and radial pin junction GaAs nanocone array solar cells is investigated. Compared with the cylinder nanowire arrays, the nanocone arrays not only improve the whole optical absorption but more i...

DOAJ Open Access (DOAJ) DOI: 10.1186/s11671-018-2727-7

Synthesize and characterization of hybrid aluminium alloy (AA6063) metal matrix composite (HAMMC) with corn cob ash and alumina (Al2O3) reinforcements

Ayenew Amare, Mezigebu Belay, Zewudu Wondimagegn • Journal of Materials Science: Materials in Engineering (2026)

Abstract The use of aluminium matrix composites (AMCs) in advanced engineering applications has increased due to their improved mechanical properties, such as hardness, ultimate tensile strength, toughness, wear, and corrosion resistance. A...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40712-026-00421-0