Academic Articles & Research Papers

The critical involvement of monocytes/macrophages in the pathogenesis of primary Sjögren's syndrome: New evidence from Mendelian randomization and single-cell sequencing

Background: Primary Sjögren's syndrome (pSS) stands as a chronic autoimmune disease characterized by an elusive pathogenesis. The synergy of single-cell RNA sequencing and Mendelian randomization (MR) analysis provides an opportunity to com...

Case Report: A severe case of immunosuppressant-refractory immune checkpoint inhibitor-mediated colitis rescued by tofacitinib

Immune checkpoint inhibitor therapy for cancer treatment can give rise to a variety of adverse events. Here we report a male patient with metastatic melanoma who experienced life-threatening colitis and duodenitis following treatment with i...

Free Amino Acids in Human Milk: A Potential Role for Glutamine and Glutamate in the Protection Against Neonatal Allergies and Infections

Breastfeeding is indicated to support neonatal immune development and to protect against neonatal infections and allergies. Human milk composition is widely studied in relation to these unique abilities, which has led to the identification ...

Draft genome sequences of two hypermucoviscous carbapenem-resistant ST25 Klebsiella pneumoniae strains causing respiratory and systemic infections

ABSTRACT: Objectives: The emergence and spread of hypermucoviscous KPC-2-producing Klebsiella pneumoniae strains belonging to the sequence type 25 (ST25) clone was reported recently in Northwest Argentina as a leading cause of nosocomial in...

Importance of background threshold value development within risk‐based corrective action programs

Abstract Risk‐based corrective action (RBCA) programs employ conservative models to develop default values for soil screening, which simplify the risk assessment process. However, for several naturally occurring metals (e.g., arsenic and le...

Coal mine methane emissions quantification based on vehicle-based monitoring

Obtaining accurate emissions of methane (CH_4), one of the most important non-carbon-dioxide greenhouse gases, is the basis for formulating and validating emission reduction policies. In terms of shortcomings from the "bottom-up" approach, ...

Research on a Comprehensive Performance Analysis Method for Building-Integrated Photovoltaics Considering Global Climate Change

Building-integrated photovoltaics (BIPVs) represent a pivotal technology for enhancing the utilization of renewable energy in buildings. However, challenges persist, including the lack of integrated design models, limited analytical dimensi...

Network Analysis of Medical Claims Data Suggests Network-Based, Regional Targeting and Intervention Delivery Strategies to Increase Access to Office Based Opioid Treatment (OBOT) for Opioid Use Disorder (OUD)

Opioid overdose and Opioid Use Disorder (OUD) statistics underscore an urgent need to significantly expand access to evidence-based OUD treatment. Office Based Opioid Treatment (OBOT) has proven effective for treating OUD. However, limited ...

Different sex ratios of children born to Indian and Pakistani immigrants in Norway

Abstract Background A low female-to-male ratio has been observed in different Asian countries, but this phenomenon has not been well studied among immigrants living in Western societies. In this study, we investigated whether a low female-t...

Predicting Microbial Protein Synthesis in Cattle: Evaluation of Extant Equations and Steps Needed to Improve Accuracy and Precision of Future Equations

Predictions of microbial crude protein (MCP) synthesis for beef cattle generally rely on empirical regression equations, with intakes of energy and protein as key variables. Using a database from published literature, we developed new equat...

An Intersection–Union Test for the Sharpe Ratio

An intersection–union test for supporting the hypothesis that a given investment strategy is optimal among a set of alternatives is presented. It compares the Sharpe ratio of the benchmark with that of each other strategy. The interse...

ltm: An R Package for Latent Variable Modeling and Item Response Analysis

The R package ltm has been developed for the analysis of multivariate dichotomous and polytomous data using latent variable models, under the Item Response Theory approach. For dichotomous data the Rasch, the Two-Parameter Logistic, and Bi...

Research and practice on key issues in the implementation of government data classification and grading in China

Data classification and grading is the foundation for ensuring the safe circulation of data and promoting the release of data value.This paper focuses on the key task of government data classification and grading in digital reform.Using a t...

TESTS OF HTS 2G SUPERCONDUCTING TAPES USING THE LABVIEW ENVIRONMENT

HTS 2G superconducting tapes without stabilizer are used for the construction of superconducting fault current limiters. The characteristics R =f(T) of the superconducting tape is essential for design of superconducting current limiters and...

Forecasting Crude Oil Price and Stock Price by Jump Stochastic Time Effective Neural Network Model

The interacting impact between the crude oil prices and the stock market indices in China is investigated in the present paper, and the corresponding statistical behaviors are also analyzed. The database is based on the crude oil prices of ...

The landscape of data sources for marine harmful algal bloom-related disease surveillance in the Philippines, Malaysia and Indonesia: a systematic scoping review.

XMM-Newton Observations of the High Temperature Plasma in the Large Magellanic Cloud Supernova Remnant N132D

We present an analysis of the archival XMM-Newton observations of the Large Magellanic Cloud (LMC) supernova remnant N132D totaling more than 500 ks. We focus on the high temperature plasma ( kT _e  ∼ 4.5 keV) that is responsible for the hi...

Is There a Retrograde Accretion Disk around 4U 1626–67? Tracking Torque Reversals with a State-space Model

X-ray timing studies of the persistent, Galactic, accretion-powered pulsar 4U 1626−67 reveal torque reversals, during which the pulse frequency ν ( t ) alternates between multiyear episodes of secular acceleration and deceleration, separate...

Social Network Analysis of Editorial Board Interlocking Phenomena from the Perspective of Astronomy and Astrophysics Journals

Editorial board members (EBMs) of journals play a pivotal role in authentic international scientific journals. Editorial Board Interlocking (EBI) phenomenon reflects the effectiveness and importance of the scholarly journal's editorial boar...

Change Detection for Hyperspectral Images Via Convolutional Sparse Analysis and Temporal Spectral Unmixing

With the increase in the availability of multitemporal hyperspectral images (HSIs), HSIs change detection (CD) methods, including pixel-level and subpixel-level based methods, have attracted great attention in recent years. However, the wid...