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Showing 20 of 9,867 academic articles

Discharge preparation experiences of intergenerational caregivers for premature infants in China’s NICU: a qualitative study

Yan Zhang, Ling Jiang, Jinyu Zhu, Sijia Shen et al. • BMJ Paediatrics Open (2026)

Background Proper discharge preparation by family caregivers is essential for improving the growth and development of preterm infants and lowering their readmission rates. Within China’s unique family cultural context, intergenerational car...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjpo-2026-004695 PMC: PMC13691880

Long Noncoding RNAs in Neurodegenerative Diseases: Pathogenesis and Potential Implications as Clinical Biomarkers

Meng Zhang, Ping He, Zhigang Bian • Frontiers in Molecular Neuroscience (2021)

Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are progressive and ultimately fatal. NDD onset is influenced by several fa...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2021.685143

Rare genetic diseases associated with G-quadruplex-induced replication stress

Lauren M. Herr, Swagata Mukhopadhyay, Olivia M. Anderson, Tucker H. Couch et al. • Communications Biology (2026)

Abstract DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substant...

DOAJ Open Access (DOAJ) DOI: 10.1038/s42003-026-09966-4

A Familial Case of Multiple Endocrine Neoplasia 2A: From Morphology to Genetic Alterations Penetration in Three Generations of a Family

Lan Chen, Jing-Xin Zhang, Dong-Ge Liu, Hong-Gang Liu • Diagnostics (2023)

This paper illustrates a rare syndrome of multiple endocrine neoplasia type 2A (MEN2A) in a family of three generations. In our case, the father, son and one daughter developed phaeochromocytoma (PHEO) and medullary thyroid carcinoma (MTC) ...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics13050955

Higher calorie intake with adequate exercise is associated with reduced mortality compared with low-calorie diet with equivalent exercise: An observational study from NHANES based on the 2020–2025 Dietary Guidelines for Americans

Hanghang Gan, Yu Yan, Shanshan Jia, Yingqiang Guo et al. • Experimental Gerontology (2025)

Object: To explore the effects of different combinations of calorie intake and exercise on all-cause, cardiovascular and cancer mortality. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weigh...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.112805

Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics

Junqi Yang, Yumin Ma, Jiang Liu, Qingtian Zhu et al. • Experimental Gerontology (2024)

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cel...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2024.112633

Linking Spiritual and Religious Coping With the Quality of Life of Community-Dwelling Older Adults and Nursing Home Residents

Luciano Magalhães Vitorino BSN, MSc, Gail Low RN, BSN, MA, PhD, Lucila Amaral Carneiro Vianna PhD • Gerontology and Geriatric Medicine (2016)

Objective: This study examined the effect of Positive and Negative Spiritual and Religious Coping (SRC) upon older Brazilian’s quality of life (QOL). Method: A secondary analysis of data collected from 77 nursing home residents (NHRs; M age...

DOAJ Open Access (DOAJ) DOI: 10.1177/2333721416658140

Impact of age-friendly living environment and intrinsic capacity on functional ability in older adults: a cross-sectional study

Yi-Shan Jiang, Hong Shi, Yu-Ting Kang, Ji Shen et al. • BMC Geriatrics (2023)

Abstract Background The World Health Organization (WHO) has proposed healthy aging framework, supposing that intrinsic capacity (IC), environment and their interaction may have influence on functional ability (FA). It was still unclear how ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-04089-5

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

Eimear Connolly, Shane Lyons, Cliona O’Farrelly, Graham Knight et al. • BMJ Open (2023)

Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the un...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2023-077772

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults

Yan Zhao, Tingting Chen, Conghua Ji, Yuxin Shang et al. • Experimental Gerontology (2026)

Background: Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.113010

The interplay of risk factors for future falls and fall-related injuries among community-dwelling older adults: a Bayesian network analysis

Yan Cai, Wei Zhu, Chenshu Wu, Yan Jiang • BMC Public Health (2026)

Abstract Background Falls are a leading global cause of injury and mortality in older adults, necessitating understanding risk factor interplay for prevention. This study aims to investigate complex interactions among risk factors associate...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12889-026-27192-9

Watching Out for Older Drivers

Samuel Durso • MedEdPORTAL (2006)

Abstract Motor vehicle accidents are the leading cause of injury-related deaths among adults age 65 to 74. This risk for traffic fatalities may triple as the numbers of older drivers increases in the coming years. It is the ethical opinion ...

DOAJ Open Access (DOAJ) DOI: 10.15766/mep_2374-8265.194

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease

Erden Eren, Jeannie-Marie Leoutsakos, Juan Troncoso, Constantine G. Lyketsos et al. • Cells (2022)

The hallmarks of Alzheimer’s disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanism...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells11030436

Heterogeneity in Trajectories of Body Mass Index and Their Associations with Mortality in Old Age: A Literature Review

Hiroshi Murayama, Benjamin A. Shaw • Journal of Obesity & Metabolic Syndrome (2017)

This article reviewed studies to investigate the association between trajectories of body mass index (BMI) and mortality among older adults. Investigators conducted a systematic search of published peer-reviewed literature in the PubMed dat...

DOAJ Open Access (DOAJ) DOI: 10.7570/jomes.2017.26.3.181

Association between Postoperative Neck Pain and Intraoperative Transcranial Motor-Evoked Potential Waveforms of the Trapezius Muscles in Patients with Cervical Myelopathy Who Underwent Cervical Laminoplasty

Sadayuki Ito, Yoshihito Sakai, Kei Ando, Hiroaki Nakashima et al. • Asian Spine Journal (2023)

Study Design Retrospective study. Purpose Cervical laminoplasty is safe and effective for treating cervical myelopathy but has a higher frequency of postoperative axial pain compared to other methods. Several studies have reported on the ca...

DOAJ Open Access (DOAJ) DOI: 10.31616/asj.2022.0120

Investigation of Play Intervention for Dementia (PID) Activities in Addressing Cognitive Domains Reflected in Hong Kong Montreal Cognitive Assessment (HK-MoCA)

Calvin Ka-Fung Lo BHSc, MD, Eric Andrew Yung BSc, MSc, Ka Tat Tsang PhD • Gerontology and Geriatric Medicine (2022)

Background/Objectives: Yee Hong Play Intervention for Dementia (PID) is a community program strengthening East Asians >65 years with dementia in their daily functional activities. We analyzed how PID activities align with Hong Kong Montreal...

DOAJ Open Access (DOAJ) DOI: 10.1177/23337214221130161

Measles IgG Antibodies: Is There a Protective Role in COVID 19 Pandemic?‎ ‎

Amira Al Balakosy, Mostafa Alfishawy, Omnia Elnabawy, Azza Hassan et al. • Afro-Egyptian Journal of Infectious and Endemic Diseases (2021)

Background and study aim: Epidemiological   data reported lower death rates of COVID-19 cases   in countries with   higher & ‎recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer ‎in COVID-1...

DOAJ Open Access (DOAJ) DOI: 10.21608/aeji.2021.72615.1144

Categorias de autocuidado entre pessoas idosas com diabetes: estudo sociopoético [Categories of self-care among older adults with diabetes: a sociopoetic study]

Iraci dos Santos, Renata Gomes Machado Guerra, Leandro Andrade da Silva • Revista Enfermagem UERJ (2015)

Teve-se como objetivo identificar as categorias de autocuidado apresentadas por pessoas idosas com diabetes, considerando suas dimensões física, mental e espiritual. Método sociopoético, aplicando as fases do grupo-pesquisador formado por 1...

DOAJ Open Access (DOAJ) DOI: 10.12957/reuerj.2015.16498

Exploring stress mediation: self-efficacy, sense of coherence, and self-esteem among nursing students in Poland—a multicenter cross-sectional observational study

Anna Maria Cybulska, Ewa Kupcewicz, Kamila Rachubińska, Mariusz Panczyk et al. • Frontiers in Public Health (2025)

BackgroundNursing students frequently encounter stressful and demanding situations during clinical training, which may hinder their well-being and professional development. A strong sense of coherence is thought to buffer the negative effec...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpubh.2025.1713759

Stage-Dependent Within-Individual Comparison Reveals SIV-Specific Activation/Exhaustion Shift in Rhesus Macaques

Ling Tong, Zhe Cong, Long Tian, Jingjing Zhang et al. • Frontiers in Microbiology (2021)

It is challenging to trace the complicated individual-based variations of HIV-specific immunocompetence shift during the successful antiretroviral therapy (ART) era. Using eight rhesus monkeys simulating a longitudinal stage-dependent cohor...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2021.704449