Academic Articles & Research Papers

Integrative multiomics analysis of platelet-related genes unveils molecular subtypes and prognostic signatures in acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) remains challenging due to molecular heterogeneity and limited prognostic models integrating tumor microenvironment dynamics. While thrombocytopenia correlates with poor outcomes, the roles of platelet-...

Immunogenic cell death-related macrophage gene model for prognostic prediction in glioblastoma

Abstract Glioblastoma (GBM) is an extremely aggressive and diverse type of brain tumor that is associated with a poor prognosis. Immunogenic cell death (ICD) is a particular form of cellular demise that is closely linked to antineoplastic i...

Application of Machine Learning for Predicting Progression‐Free and Overall Survival in Patients With Renal Cell Carcinoma

ABSTRACT Patient outcomes in advanced renal cell carcinoma (RCC) remain poor, with five‐year survival rates ranging from ~10% to 30%. Early projections of therapeutic outcomes could optimize precision medicine and accelerate drug developmen...

A false sense of hypoxia: Pro‑tumorigenic VHL‑HIF2α dysregulation in clear cell renal cell carcinoma (Review).

PCPAm - A dataset of histopathological images of penile cancer for classification tasksZenodo

Penile cancer has an incidence strongly linked to sociocultural factors, being more common in underdeveloped countries like Brazil, where it represents approximately 2% of cancers affecting men. This dataset was created to address the scarc...

Simulation-based Bayesian deep learning enables uncertainty-aware tumor fraction estimation in cell-free DNA.

Predicting Choroidal Nevus Transformation to Melanoma Using Machine Learning

Purpose: To develop and validate machine learning (ML) models to predict choroidal nevus transformation to melanoma based on multimodal imaging at initial presentation. Design: Retrospective multicenter study. Participants: Patients diagnos...

Advances in ligand-targeted nanodelivery systems for leukemia therapy: from single- to dual-ligand strategies

Abstract Background Leukemia is a highly heterogeneous and aggressive hematological malignancy. Current therapeutic approaches (e.g. chemotherapy, radiotherapy, small-molecule targeted therapies, and hematopoietic stem cell transplantation,...

The Prognostic Role of CD8(+) Tumor-Infiltrating Lymphocyte Density in Head and Neck Mucosal Melanoma.

Vital Hepatic Lymphoma Residuum or Excessive Immune Response? Challenging Treatment Decisions in a Patient With Systemic Lupus Erythematosus and Liver-Dominant Diffuse Large B-Cell Lymphoma: Case Report

A 28-year-old female patient with active and difficult-to-treat systemic lupus erythematosus (SLE) was diagnosed with liver-dominant diffused large B-cell lymphoma. Repeated response 18F-FDG-PET studies showed persistently high, and, despit...

Artificial intelligence in pancreatic cancer

Pancreatic cancer is the deadliest disease, with a five-year overall survival rate of just 11%. The pancreatic cancer patients diagnosed with early screening have a median overall survival of nearly ten years, compared with 1.5 years for th...

Associations of County-Level Urbanicity With Overall Survival Across 19 Solid Tumor Groups, 2004-2023: A SEER Cohort Study of 5.5 Million Patients.

Development of a nomogram for preoperative prediction of malignant risk in thyroid follicular tumors based on multimodal ultrasound and clinical features: A retrospective observational study.

A Multidimensional CT-Based Tumor Location Metric for Predicting Lymph Node Metastasis and Occult Lymph Node Metastasis in Lung Adenocarcinoma.

An automated deep learning framework for brain tumor classification using MRI imagery

Abstract The precise and timely diagnosis of brain tumors is essential for accelerating patient recovery and preserving lives. Brain tumors exhibit a variety of sizes, shapes, and visual characteristics, requiring individualized treatment s...

Radiomics and radiogenomics: extracting more information from medical images for the diagnosis and prognostic prediction of ovarian cancer

Abstract Ovarian cancer (OC) remains one of the most lethal gynecological malignancies globally. Despite the implementation of various medical imaging approaches for OC screening, achieving accurate differential diagnosis of ovarian tumors ...

A Study on the Effectiveness of Deep Learning-Based Anomaly Detection Methods for Breast Ultrasonography

In the medical field, it is delicate to anticipate good performance in using deep learning due to the lack of large-scale training data and class imbalance. In particular, ultrasound, which is a key breast cancer diagnosis method, is delica...

Predictive digital twin for optimizing patient-specific radiotherapy regimens under uncertainty in high-grade gliomas

We develop a methodology to create data-driven predictive digital twins for optimal risk-aware clinical decision-making. We illustrate the methodology as an enabler for an anticipatory personalized treatment that accounts for uncertainties ...

Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types

Abstract Background Homologous recombination deficiency (HRD) is recognized as a pan-cancer predictive biomarker that potentially indicates who could benefit from treatment with PARP inhibitors (PARPi). Despite its clinical significance, HR...

Preoperative and Prognostic Prediction of Microvascular Invasion in Hepatocellular Carcinoma: A Review Based on Artificial Intelligence

Microvascular invasion of hepatocellular carcinoma is an important factor affecting tumor recurrence after liver resection and liver transplantation. There are many ways to classify microvascular invasion, however, an international consensu...