Academic Articles & Research Papers

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Abstract Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer ...

Finite element analysis on the near field properties of metallic cavities with atomic sharpness

Using finite element calculations, we investigated the near field properties of two types of commonly used metal nanostructures (a tip-substrate model representing a scanning tunneling microscope type setup (TS) and a nanoparticle-on-mirror...

Functionalization of polyoxometalates: towards advanced applications in catalysis and materials science

Functionalization via covalent grafting of organic functions allows to tune the redox and acid-base properties, and the solubility of polyoxometalates, to enhance their stability and biological activity and to reduce their toxicity, to faci...

Thermodynamics and Kinetics in Materials Science

This text presents a concise and thorough introduction to the main concepts and practical applications of thermodynamics and kinetics in materials science. It is designed with two types of uses in mind: firstly for one or two semester unive...

Study on Association Between Lipid Profile Values and Psychiatric Disorders

Background: Cholesterol is especially abundant in nervous system, where it plays important role in different aspects of cellular structure (e.g. fluidity of cell membranes) and function (e.g. membrane). Several studies showed that there ...

RETRACTED ARTICLE: A brief comparative examination of tangent hyperbolic hybrid nanofluid through a extending surface: numerical Keller–Box scheme

Abstract A novel hybrid nanofluid was explored in order to find an efficient heat-transmitting fluid to replace standard fluids and revolutionary nanofluids. By using tangent hyperbolic hybrid combination nanoliquid with non-Newtonian ethyl...

An In Vitro Study of Local Oxygen Therapy as Adjunctive Antimicrobial Therapeutic Option for Patients with Periodontitis

Periodontitis is a common global disease caused by bacterial dysbiosis leading to tissue destruction, and it is strongly associated with anaerobic bacterial colonization. Therapeutic strategies such as oxygen therapy have been developed to ...

External Thermal Insulation Composite Systems: Critical Parameters for Surface Hygrothermal Behaviour

External Thermal Insulation Composite Systems (ETICS) are often used in Europe. Despite its thermal advantages, low cost, and ease of application, this system has serious problems of biological growth causing the cladding defacement. Recent...

Superconductivity emerging from a stripe charge order in IrTe2 nanoflakes

Superconductivity often appears due to suppression of competing electronic orders. Here, the authors present a contrary example showing a superconducting dome inside the parent phase with a stripe charge order in IrTe2 nanoflakes and identi...

Highly Sensitive and Specific Detection of Influenza A Viruses Using Bimolecular Fluorescence Complementation (BiFC) Reporter System

In this study, we developed a highly sensitive and specific bimolecular fluorescence complementation (BiFC)-based influenza A virus (IAV)-sensing system by combining a galactose/glucose-binding protein (GGBP) with an N-terminal large domain...

Advances of medical nanorobots for future cancer treatments

Abstract Early detection and diagnosis of many cancers is very challenging. Late stage detection of a cancer always leads to high mortality rates. It is imperative to develop novel and more sensitive and effective diagnosis and therapeutic ...

A nanotechnology-based approach to enhance caraway (Carum carvi L.) productivity, chemical, biochemical and essential oil under salinity stress

Salt stress is an abiotic stressor that adversely affects the growth and productivity of caraway, an important aromatic plant. A randomized complete split-plot design was used to determine the nanoparticles of zinc oxide (ZnO NPs) effects a...

Decellularized Placental Sponge: A Platform for Coculture of Mesenchymal Stem Cells/Macrophages to Assess an M2 Phenotype and Osteogenic Differentiation In Vitro and In Vivo

Silver Nanoparticles Suppress Apple Fire Blight: Antibacterial Activity, Reduced Carbohydrate-Containing EPS Content, and Altered Host Antioxidant Responses

The present study evaluated the phytoprotective activity of silver nanoparticles stabilized with sodium amphopolycarboxyglycinate (AgNPs-APCG) against apple fire blight caused by Erwinia amylovora. A highly colloidally stable AgNPs-APCG dis...

Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives

The antitumor drug 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ (1)) along with a number of newly synthesized tirapazamine derivatives (TPZs) bearing substitutions at the 3-amine position of TPZ (1) were estimated for their an...

Development of a Portable Electrochemical Platform with Chip-Integrated Gold Electrodes for Detection of Pharmaceutical Pollutants

Electrochemical portable sensing systems can offer viable support in the analysis of environmental contaminants due to the compactness of their electronic components and overall simplicity of their detection principles. In the present work,...

Facile Synthesis of Propranolol and Novel Derivatives

Propranolol is one of the first medications of the beta-blocker used for antihypertensive drugs. This study reports the facile route for the synthesis of propranolol and its novel derivatives. Herein, propranolol synthesis proceeded from 1-...

Evaluation of resistance modulation in MDR Pseudomonas aeruginosa and Klebsiella pneumoniae using peppermint oil nanoemulsion: integrating antibacterial assays and molecular modeling

IntroductionMultidrug-resistant urinary tract pathogens, primarily Klebsiella pneumoniae and Pseudomonas aeruginosa, represent a significant and growing public health challenge. The overuse of antibiotics has accelerated the development of ...

Induced Topological Superconductivity in a BiSbTeSe₂-Based Josephson Junction

A 4 π -periodic supercurrent through a Josephson junction can be a consequence of the presence of Majorana bound states. A systematic study of the radio frequency response for several temperatures and frequencies yields a concrete proto...

Optimization and Clinical Evaluation of a Multi-Target Loop-Mediated Isothermal Amplification Assay for the Detection of SARS-CoV-2 in Nasopharyngeal Samples

SARS-CoV-2 is the coronavirus responsible for COVID-19, which has spread worldwide, affecting more than 200 countries, infecting over 140 million people in one year. The gold standard to identify infected people is RT-qPCR, which is highly ...