Machine-learning-guided directed evolution for protein engineering
https://doi.org/10.1038/s41592-019-0496-6
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https://doi.org/10.1038/s41592-019-0496-6
We review machine learning methods employing positive definite kernels. These methods formulate learning and estimation problems in a reproducing kernel Hilbert space (RKHS) of functions defined on the data domain, expanded in terms of a ke...
https://doi.org/10.1214/009053607000000677
Port congestion and prolonged ship waiting times pose challenges for global trade and increase operational costs and inefficiencies. In this study, a novel machine learning-based predictive approach was proposed to improve port operations b...
10.1109/ACCESS.2025.3566429
Relevance. Core studies in the oil and gas industry allow us to obtain some filtration and capacity characteristics of rocks, as well as to give an idea of the composition and structure of the subsoil. This information is extremely importan...
10.18799/24131830/2024/9/4792
This paper introduces Rectified Discriminatory Delta-Adjust (RDDA), a novel methodology that enhances interpolation-based predictive modeling through adaptive sensitivity parameters. Building upon the foundational Delta-Adjust algorithm, RD...
10.1109/ACCESS.2025.3641537
We perform a comparative analysis of machine learning methods for the canonical problem of empirical asset pricing: measuring asset risk premia.We demonstrate large economic gains to investors using machine learning forecasts, in some cases...
https://doi.org/10.3386/w25398
In recent years, many new clinical diagnostic tools have been developed using complicated machine learning methods. Irrespective of how a diagnostic tool is derived, it must be evaluated using a 3-step process of deriving, validating, and e...
https://doi.org/10.1001/jama.2019.16489
Gaussian processes (GPs) are natural generalisations of multivariate Gaussian random variables to infinite (countably or continuous) index sets. GPs have been applied in a large number of fields to a diverse range of ends, and very many dee...
https://doi.org/10.1142/s0129065704001899
Nuclear physics deals with complex systems, large datasets, and complicated correlations between parameters, which makes the field suitable for the application of machine learning techniques. Machine learning can help classify and analyze d...
https://doi.org/10.1103/revmodphys.94.031003
Electrocatalysts and photocatalysts are key to a sustainable future, generating clean fuels, reducing the impact of global warming, and providing solutions to environmental pollution. Improved processes for catalyst design and a better unde...
https://doi.org/10.1021/acs.chemrev.2c00061
Abstract Big data and artificial intelligence has revolutionized science in almost every field – from economics to physics. In the area of materials science and computational heterogeneous catalysis, this revolution has led to the developme...
https://doi.org/10.1002/cctc.201900595
Artificial intelligence (AI) broadly refers to analytical algorithms that iteratively learn from data, allowing computers to find hidden insights without being explicitly programmed where to look. These include a family of operations encomp...
https://doi.org/10.1136/heartjnl-2017-311198
Reconstructing ocean dynamics from observational data is fundamentally limited by the sparse, irregular, and Lagrangian nature of spatial sampling, particularly in subsurface and remote regions. This sparsity poses significant challenges fo...
10.1088/3049-4753/ae0b70
Precise forecasting of water quality indices (WQI) is essential for safeguarding ecosystems, human health, and sustainable water resource management. This study presents an innovative approach for evaluating river Water Quality Indices usin...
10.1080/19942060.2025.2602582
Computing phenotypic similarity helps identify new disease genes and diagnose rare diseases. Genotype–phenotype data from orthologous genes in model organisms can compensate for lack of human data and increase genome coverage. In the past d...
10.1242/dmm.049441
https://doi.org/10.1038/nmeth.4642
PMC: 6082636
Prostate cancer can be viewed as the second most dangerous and diagnosed cancer of men all over the world. In the past decade, machine and deep learning methods play a significant role in improving the accuracy of classification for both bi...
https://doi.org/10.21928/uhdjst.v5n2y2021.pp41-47
The growing adoption of IoT applications has led to increased use of low-power microcontroller units (MCUs) for energy-efficient, local data processing. However, deploying deep neural networks (DNNs) on these constrained devices is challeng...
10.3390/s25154595
BackgroundSentiment analysis is a significant yet difficult task in natural language processing. The linguistic peculiarities of Cantonese, including its high similarity with Standard Chinese, its grammatical and lexical uniqueness, and its...
10.2196/51069
This article introduces a hybrid variant of a physics-informed neural network (PINN) that is designed to effectively capture both the rapid dynamics of electrical variables and the slower dynamics of state parameters in a domestic induction...
10.1109/OJIES.2026.3663897