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PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway

Liwei Wu, Qiang Yu, Ping Cheng, Chuanyong Guo • PPAR Research (2021)

Background. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damag...

DOAJ Open Access (DOAJ) DOI: 10.1155/2021/6626295

Bone turnover markers and parameters of functional and structural state in patients with chronic spinal cord injuries in 5 years and later after the trauma

M.A. Bystrytska, V.V. Povoroznyuk • Bolʹ, Sustavy, Pozvonočnik (2017)

Актуальность. Увеличение продолжительности жизни пациентов с травмой позвоночника и спинного мозга (ТПСМ) привлекло внимание к поздним осложнениям ТПСМ, в частности к остеопорозу. Цель исследования — оценить структурно-функциональное состоя...

DOAJ Open Access (DOAJ) DOI: 10.22141/2224-1507.7.2.2017.108700

Effective analysis of neurotoxicity and mechanisms of dioctyl terephthalate using network toxicology

Hao Tang, Ting Qin, Zhiwen Yan, Changqing Li et al. • Frontiers in Neuroscience (2026)

ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mec...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2026.1783807

Using Wearable Devices to Examine the Associations of Sedentary Behavior with Perceived and Performance Fatigability Among Older Adults: The Study of Muscle, Mobility and Aging (SOMMA)

Reagan E. Garcia, Anne B. Newman, Eileen Johnson, Yujia Susanna Qiao et al. • Sensors (2025)

Fatigability, a phenotype of poor energy regulation, is associated with lower physical activity in older adults, but independent associations with sedentary behavior are unknown. We examined whether sedentary behavior was associated with fa...

DOAJ Open Access (DOAJ) DOI: 10.3390/s25092722

The burden and determinants of cognitive impairment among individuals with chronic diseases in Ethiopia: A systematic review and meta-analysis

Addisu Getie, Melaku Bimerew, Mihretie Gedfew, Baye Tsegaye Amlak et al. • Archives of Gerontology and Geriatrics Plus (2025)

Introduction: Cognitive impairment is a medical condition caused by neurodegeneration, marked by a gradual decline in neurological, motor, psychological, and cognitive domain functions, as well as daily activities. It primarily affects indi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aggp.2025.100171

Types of Skin Afferent Fibers and Spinal Opioid Receptors that Contribute to Touch-Induced Inhibition of Heart Rate Changes Evoked by Noxious Cutaneous Heat Stimulation

Nobuhiro Watanabe, Mathieu Piché, Harumi Hotta • Molecular Pain (2015)

Background In anesthetized rats and conscious humans, a gentle touch using a soft disc covered with microcones (with a texture similar to that of a finger), but not with a flat disc, inhibits nociceptive somatocardiac reflexes. Such an inhi...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12990-015-0001-x

Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits

Mateus H. Gouveia, Amy R. Bentley, Hampton Leonard, Karlijn A. C. Meeks et al. • Scientific Reports (2021)

Abstract Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specif...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-021-83450-3

Procedural Results and Long-Term Outcomes of Percutaneous Coronary Intervention for in-Stent Restenosis Chronic Total Occlusion Compared with de novo Chronic Total Occlusion

Tang G, Zheng N, Yang G, Li H et al. • International Journal of General Medicine (2021)

Guodong Tang, Naixin Zheng, Guojian Yang, Hui Li, Hu Ai, Ying Zhao, Fucheng Sun, Huiping Zhang Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences,...

DOAJ Open Access (DOAJ)

Associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older adults

Emi Miki, Risa Kawabata • Cadernos Brasileiros de Terapia Ocupacional (2020)

This study aimed to investigate the associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older Japanese adults by examining the correlations between the Canadian Occup...

DOAJ Open Access (DOAJ) DOI: 10.4322/2526-8910.ctoAO2096

Broca’s biases in modern aphasiology

Silvia Martínez-Ferreiro, Monica I. Norvik, Monica I. Norvik • Frontiers in Human Neuroscience (2026)

Broca’s description of aphemia signals the emergence of aphasiology as a discipline. It also marks the beginning of a long tradition of studies of right-handed patients (“Nous parlons avec l’hémisphère gauche”) with lesions in the inferior ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2026.1783073

<i>Sechium edule</i> var. <i>nigrum spinosum</i> (Chayote) Increases the mRNA Expression of Genes Encoding Sirtuins in Older Adults with Type 2 Diabetes Mellitus

Graciela Gavia-García, David Hernández-Álvarez, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez et al. • Molecules (2026)

Consumption of Sechium edule var. nigrum spinosum has antioxidant and hypoglycemic effects. Regarding the former, certain signaling pathways that influence these effects have already been proposed; however, the underlying molecular mechanis...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules31071182

Having More Daughters Independently Predicts Home Discharge in Stroke Patients Admitted to Inpatient Rehabilitation Ward

Shiau-Fu Hsieh, Kuo-Liong Chien, Chu-Hao Weng, Yi-Ping Chiang • International Journal of Gerontology (2017)

Background: The predictors for failure of home discharge after post-acute inpatient stroke rehabilitation need investigation. Methods: With this retrospective case-control study conducted in a stroke rehabilitation unit in one tertiary hosp...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ijge.2017.07.005

A review of studies that used B mode ultrasound to estimate age-related changes in anterior thigh skeletal muscle thickness across the adult lifespan

Isobel Jacob, Gareth Jones, Peter Francis, Mark I Johnson • Archives of Gerontology and Geriatrics Plus (2024)

Background: The purpose of this review was to synthesise and determine the age-related change per annum in muscle thickness of the anterior thigh across the adult lifespan. Methods: Electronic databases (PubMed, SPORTDiscus and MEDLINE) wer...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aggp.2024.100037

Residential Satisfaction of Rural Older Adults Aging in Place

Sung-Jin Lee PhD, Kathleen Rose Parrott PhD, Minyong Lee PhD, Sheryl Renee Robinson BS et al. • Gerontology and Geriatric Medicine (2021)

This study explored residential (housing and town) satisfaction of rural older adults aging in place, relating to demographic and housing characteristics. We conducted a structured, face-to-face survey with 149 rural older adults. Regressio...

DOAJ Open Access (DOAJ) DOI: 10.1177/2333721421997190

Uncovering the Tradeoffs and Synergies of Ecosystem Services in Mining Landscapes: Spatiotemporal and Factor Detection Perspective

Jiao Pan, Tao Chen, Antonio Plaza • IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2025)

Revealing the spatial-temporal evolution and interactions of ecosystem services (ESs) in mining area is critical for sustainable environmental management. The temporal and spatial characteristics and changing trends of six ESs in Yuzhong mi...

DOAJ Open Access (DOAJ) DOI: 10.1109/JSTARS.2025.3586637

Magnetic Field Dipolarization and Its Associated Ion Flux Variations in the Dawnside Deep Inner Magnetosphere: Arase Observations

M. Nosé, A. Matsuoka, S. Kasahara, S. Yokota et al. • Geophysical Research Letters (2018)

Abstract The Arase satellite observed clear dipolarization signatures at r~4.3–4.6 RE, GMLAT~16°–18°, and MLT~5.5–5.7 hr around 15:00 UT on 27 March 2017 when Dst~−70 nT. Strong magnetic field fluctuations were embedded and their characteri...

DOAJ Open Access (DOAJ) DOI: 10.1029/2018GL078825

New palaeomagnetic data for Palaeoproterozoic AMCG complexes of the Ukrainian Shield

V.G. Bakhmutov, O.V. Mytrokhyn, I.B. Poliachenko, S.I. Cherkes • Геофизический журнал (2023)

A palaeomagnetic study of rocks for two Palaeoproterozoic anorthosite-mangerite-charnockite-granite (AMCG) complexes in the Ukrainian Shield was done to put additional constraints on the interpretation of palaeogeography of Fennoscandia and...

DOAJ Open Access (DOAJ) DOI: 10.24028/gj.v45i4.286283

A multi-instrumental and modeling analysis of the ionospheric responses to the solar eclipse on 14 December 2020 over the Brazilian region

L. C. A. Resende, L. C. A. Resende, Y. Zhu, C. M. Denardini et al. • Annales Geophysicae (2022)

This work presents an analysis of the ionospheric responses to the solar eclipse that occurred on 14 December 2020 over the Brazilian sector. This event partially covers the south of Brazil, providing an excellent opportunity to study the m...

DOAJ Open Access (DOAJ) DOI: 10.5194/angeo-40-191-2022