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Chromosomal Instability in Various Generations of Human Mesenchymal Stem Cells Following the Therapeutic Radiation

Majid Sadeghi Moghadam, Hosein Azimian, Jalil Tavakol Afshari, Mohammad Taghi Bahreyni Toossi et al. • Stem Cells International (2023)

Background. Radiotherapy is a crucial treatment for most malignancies. However, it can cause several side effects, including the development of secondary malignancies due to radiation-induced genomic instability (RIGI). The aim of this stud...

DOAJ Open Access (DOAJ) DOI: 10.1155/2023/9991656

A Novel Prognostic Scoring Model for Myelodysplastic Syndrome Patients With SF3B1 Mutation

Liya Ma, Bin Liang, Huixian Hu, Wenli Yang et al. • Frontiers in Oncology (2022)

The outcomes of myelodysplastic syndrome (MDS) patients with SF3B1 mutation, despite identified as a favorable prognostic biomarker, are variable. To comprehend the heterogeneity in clinical characteristics and outcomes, we reviewed 140 MDS...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2022.905490

Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi et al. • Scientific Reports (2017)

Abstract For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-017-06872-y

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

Kevin Achberger, Christopher Probst, Jasmin Haderspeck, Sylvia Bolz et al. • eLife (2019)

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.46188

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy

Wei Liu, Yan Xu, Yi Wang, Lugui Qiu et al. • Journal for ImmunoTherapy of Cancer (2024)

Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or prog...

DOAJ Open Access (DOAJ) DOI: 10.1136/jitc-2023-008450

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells

Xinbo Wang, Jiaying Miao, Sizhen Wang, Rongxi Shen et al. • Molecular Cancer (2022)

Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features. Me...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-022-01596-8

Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis

Mengqiang Fan, Peijian Tong, Li Yan, Ting Li et al. • BMC Medicine (2023)

Abstract Background Articular injection of mesenchymal stem cells (MSCs) has been applied to treat knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated whether an articular inflammatory microenviro...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12916-023-02923-6

Accomplishments in genome‐scale in silico modeling for industrial and medical biotechnology

Caroline B. Milne, Pan‐Jun Kim, James A. Eddy, Nathan D. Price • Biotechnology Journal (2009)

Driven by advancements in high-throughput biological technologies and the growing number of sequenced genomes, the construction of in silico models at the genome scale has provided powerful tools to investigate a vast array of biological sy...

OPENALEX Open Access DOI: https://doi.org/10.1002/biot.200900234 PMC: 3160784

Medical biotechnology

Firdos Alam Khan • CRC Press eBooks (2018)

This chapter explains the role of biotechnology in medicine and explores the process of making antibodies and hybridoma technology. It shows how vaccines are manufactured and discusses the significance of stem cell therapy and the related i...

OPENALEX DOI: https://doi.org/10.1201/9781315370767-9

Medical Biotechnology

Simmi Kharb, Akshat Vikram Singh, Abhyuday Singh, Deepa Kharb • BENTHAM SCIENCE PUBLISHERS eBooks (2023)

Medical biotechnology incorporates many of the topics that have already been discussed in this book. Right from developing new drugs to prospects of stem cell use and cloning, the possibilities are enormous....

OPENALEX DOI: https://doi.org/10.2174/9789815080742123010013

Regulatory requirements for the registration of generic medicines and format of drug dossiers: procedures in Sri Lanka in comparison with selected regulatory authorities

D. Thambavita, P. Galappatthy, R. L. Jayakody • Journal of Pharmaceutical Policy and Practice (2018)

Background The regulatory requirements for approval of generic medicines and the format of compiling drug dossiers vary among regulatory authorities. The variation is particularly wide between High-income countries (HIC) and lower and middl...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40545-018-0141-2

Social Media Listening to Understand the Lived Experience of Individuals in Europe With Metastatic Breast Cancer: A Systematic Search and Content Analysis Study

Manuelita Mazza, Maria Piperis, Sathyaraj Aasaithambi, Jyoti Chauhan et al. • Frontiers in Oncology (2022)

BackgroundDespite a wealth of real-world data on metastatic breast cancer (mBC), insights into the lived experience are lacking. This study aimed to explore how the lived experience of mBC is described on social media.MethodsA predefined se...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2022.863641