Academic Articles & Research Papers

Current Evidence on Gene-Based and Epigenetic Therapeutic, Diagnostic, and Prognostic Strategies in Epithelial-Derived Carcinomas: A Scoping Review

Background: Epithelial-derived carcinomas exhibit genomic instability due to genetic mutation and epigenetic dysregulation. Mechanisms such as DNA methylation, histone modifications, and noncoding RNA regulation may lead to tumor progressio...

Mitophagy: An Emergence of New Player in Alzheimer’s Disease

Mitochondria provide neurons not only energy as ATP to keep them growing, proliferating and developing, but they also control apoptosis. Due to their high bioenergetic demand, neurons which are highly specific terminally differentiated cell...

Lipidomic Analysis of Caenorhabditis elegans Embryos

Metabolomic is an emerging field of system biology. Lipidomic, a branch of metabolomic, aims to characterize lipophilic metabolites in biological systems. Caenorhabditis elegans (C. elegans) is a genetically tractable and versatile animal m...

Genomic sciences and medical biotechnology

The advent of genomic sciences has provided enormous information on the gene content and its expression in a wide variety of organisms, including the human. This has paved the way for understanding the differences between normal and abnorma...

Economic Considerations in Medical Biotechnology

The biotechnology revolution has coincided with another revolution in health care: the emergence of finance and economics as major issues in the use and success of new medical technologies. Health care finance has become a major social issu...

Medical biotechnology

Resistance to entering the UK government's modern slavery victim identification mechanism is widespread and part of normal practices of state evasion that shape the lives of large numbers of insufficiently documented people.This article pro...

Medical Biotechnology Innovation in India

This book examines the medical biotechnology industry in India through the lens of a critical political economy. It discusses the sharp trajectory of growth in the biotechnology business and the state of investments, subsidies, and patents ...

CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy

Abstract Cell division cycle 25 (CDC25) phosphatases serve as crucial regulators of cell cycle phase transitions and essential components of the checkpoint machinery involved in DNA damage response. Emerging evidence indicates the oncogenic...

Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy

Abstract Background Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, therapy-refractory condition driven by ferroptotic disruption of jawbone-derived mesenchymal stem cells (MSCs) biology. We dissect this mechanism to va...

The Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis

Rupesh K Srivastava, Leena Sapra Immunoporosis Lab, Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, IndiaCorrespondence: Rupesh K Srivastava, Tel +91 11-26593548, Email rupesh_srivastava13@ya...

Expression of Recombinant Human Amelogenin in Iranian Lizard Leishmania and Its Biological Function Assay

Background: Amelogenins are the major components of enamel matrix proteins. Enamel matrix derivatives (EMD) can be used in periodontal diseases to regenerate periodontal tissues. The main aim of this study was to evaluate ex-pression of ful...

YAP1 reactivation in cardiomyocytes following ECM remodelling contributes to the development of contractile force and sarcomere maturation

Abstract Cardiac diseases are fueled by extracellular matrix (ECM) remodelling. Together with the altered ECM chemical composition, the mechanical turmoil associated with ECM maladaptive remodelling in the pathological heart drives the shut...

Dietary nutrition, intestinal microbiota dysbiosis and post-weaning diarrhea in piglets

Weaning is a critical transitional point in the life cycle of piglets. Early weaning can lead to post-weaning syndrome, destroy the intestinal barrier function and microbiota homeostasis, cause diarrhea and threaten the health of piglets. T...

Medical Biotechnology: Problems and Prospects in Bangladesh

Biotechnology is the knowledge and techniques of developing and using biological systems for deriving special products and services. The age-old technology took a new turn with the advent of recombinant DNA techniques, and boosted by the de...

Medical Biotechnology in Society

This chapter provides relevant scientific and historical information relating to genetic testing and human embryonic stem (hES) cell therapies and describes some of the societal issues surrounding them. The risks of invasive diagnostic test...

Medical biotechnology: prospects in Malaysia

The blooming interdisciplinary research in Science, Technology, Engineering and Mathematics (STEM) is well-received by scientists who perceived this as a massive opportunity to the great era of medical biotechnology. In Malaysia, tropical d...

Synthesis of Lawsonia inermis-encased silver–copper bimetallic nanoparticles with antioxidant, antibacterial, and cytotoxic activity

RETRACTED ARTICLE: Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus

Abstract Background Excessive autoantibody production characterizing systemic lupus erythematosus (SLE) occurs irrespective of the disease’s clinical status and is linked to increased lymphocyte apoptosis. Herein, we tested the hypothesis t...

Specific egg yolk immunoglobulin as a promising non-antibiotic biotherapeutic product against Acinetobacter baumannii pneumonia infection

Abstract Acinetobacter baumannii is a serious health threat with a high mortality rate. We have already reported prophylactic effects of IgYs raised against OmpA and Omp34 as well as against inactivated whole-cell (IWC) of A. baumannii in a...

Flexibility-powered Pickering emulsion enhances mucus permeability to alleviate ulcerative colitis

Abstract The physicochemical properties of oral drug delivery carriers significantly influence their interactions with the intestinal barrier, which, in turn, affect their in vivo fate and therapeutic efficacy. As a delivery system with a h...