Academic Articles & Research Papers

Research software: A key (neglected) component of the digital research infrastructure ecosystem

Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis

Jian Cheng, Yangfeng Huang Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, School of Medicine,University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of ChinaCorrespond...

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory

Summary: In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, the specific behavioral conditions that lead to circuit disinhibition remai...

Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...

Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data

Abstract Background Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants ...

Computational analyses on delineating specificity of 2-hydroxy-3,5-dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins

We have herein computationally examined binding affinities and specificity of 2-hydroxy-3,5-dinitrobenzamide (HDNB), a small chemical molecular BH3-mimetic identified by means of ‘peptidodynmimetic method’, on the BH3-binding grooves of six...

Identification of Dysregulated Mechanisms and Candidate Gene Markers in Chronic Obstructive Pulmonary Disease

Jie Lin,1,2,* Yanlong Xue,1,2,* Wenyan Su,1,2,* Zan Zhang,1,2 Qiu Wei,1,2 Tianxia Huang1,2 1Department of Respiratory and Critical Care, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530022, Peop...

CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia

Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia. Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are involved in the regulation of physiological and pathophy...

Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases

Abstract Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and other neurological disea...

Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline

Polycystic ovary syndrome (PCOS) is the most common cause of women’s infertility. Some inflammatory pathways play a pivotal role in the pathogenesis of PCOS. This study aimed to investigate the possible beneficial effects of minocycline on ...

A Kalman-Jacobi hybrid model for game theory: a fuzzy logic approach to financial market competition

PurposeThis research examines the structure of financial markets by integrating game theory and fuzzy logic. The objective is to develop a differential game model that analyzes competition among financial firms within a specific industry.De...

EFISIENSI PEGADAIAN SYARIAH DAN PROSPEK PERTUMBUHAN ASET DI INDONESIA

The purpose of this study is to analyze the efficiency of Islamic Pawnshop together with four competitors and analyze the prospects for assets growth of the Islamic pawnshop in Indonesia. This study is quantitative analyze research with sec...

Firms’ Characteristics and Debt Maturity Structure of Listed Oil and Gas Firms in Nigeria

The objective of our paper is to examine the nexus between firms' characteristics and debt maturity structure in Nigeria. The financial statements of all oil and gas listed firms in Nigeria between 2012 and 2023 provided the secondary data ...

Assessing banks efficiency: DEA implementation

By examining intermediate, operating, and profitability aspects, this paper aims to construct a performance model for evaluating the relative efficiency and potential for improvement of 20 banks operating in Serbia for the 2022-2023 period....

An overview of the literature on environmental management accounting: Bibliometric analysis method

Environmental Management Accounting (EMA) is crucial to ensure business sustainability. EMA helps businesses monitor and assess environmental activities by providing financial and non-financial information and supporting strategic decision-...

Optimized Manufacture of Lyophilized Dermal Fibroblasts for Next-Generation Off-the-Shelf Progenitor Biological Bandages in Topical Post-Burn Regenerative Medicine

Cultured fibroblast progenitor cells (FPC) have been studied in Swiss translational regenerative medicine for over two decades, wherein clinical experience was gathered for safely managing burns and refractory cutaneous ulcers. Inherent FPC...

The Effect of Capital Intensity, Audit Quality, Thin Capitalization, and Gender Diversity on Tax Aggressiveness

This study aims to analyze the effects of capital intensity, audit quality, thin capitalization, and gender diversity on tax aggressiveness in state-owned enterprises (SOEs) listed on the Indonesia Stock Exchange (IDX) from 2020 to 2023. Th...

Measuring bank efficiency: DEA application

The paper aims to improve the methodology of measuring efficiency of Latvian banks. Efficiency scores were calculated with application of non-parametric frontier technique Data Envelopment Analysis (DEA). Input-oriented DEA model under Vari...

Misalignment-modulated magnetoelastic transduction for field-tunable stiffness in chain-like magnetorheological elastomers: a Green-function-weighted traction-transfer framework

Magnetorheological elastomers (MREs) are field-responsive composites whose stiffness can be tuned by a magnetic field. In chain-like MREs, strong local magnetic interactions and Maxwell tractions do not necessarily translate into a measurab...

Grain boundary and texture evolution of TiB/Ti–2Al–6Sn titanium matrix composite under electroshocking treatment

This work used electroshocking treatment (EST) plus external loading to regulate the microstructure of titanium matrix composites (TMCs). The external loading was 0.3 MPa. After EST plus external loading with 0.3 MPa, the α was reduced to 2...