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Academic Articles & Research Papers
Showing 20 of 7,962 academic articles
Alexandra Kühnlein, Simon A Lanzmich, Dieter Braun • eLife
(2021)
Can replication and translation emerge in a single mechanism via self-assembly? The key molecule, transfer RNA (tRNA), is one of the most ancient molecules and contains the genetic code. Our experiments show how a pool of oligonucleotides, ...
DOAJ
Open Access (DOAJ)
DOI: 10.7554/eLife.63431
Sai Shashank Chavali, Steven Z. Chou, Wenxiang Cao, Thomas D. Pollard et al. • Nature Communications
(2024)
Abstract Arp2/3 complex nucleates branched actin filaments for cell and organelle movements. Here we report a 2.7 Å resolution cryo-EM structure of the mature branch junction formed by S. pombe Arp2/3 complex that provides details about int...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41467-024-46179-x
Lucas Rodrigues Moraes, Pedro Leme Silva, Denise Battaglini, Patricia Rieken Macedo Rocco • Medicina
(2026)
Acute respiratory distress syndrome (ARDS) is a heterogeneous inflammatory lung injury marked by increased alveolar–capillary permeability, reduced respiratory system compliance, and impaired gas exchange. Despite advances in supportive car...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/medicina62020420
Nobuhiko Kajinami, Mitsuhiro Matsumoto • Biophysics and Physicobiology
(2019)
Human knee joints move smoothly under high load conditions due to articular cartilage and synovial fluid. Much attention is paid to the role of proteoglycans. It is suggested that a part of proteoglycan forms aggregate on the cartilage surf...
DOAJ
Open Access (DOAJ)
DOI: 10.2142/biophysico.16.0_466
Qinghua Luo, Xintan Dong, Zhaxi Zerang, Yujiao Chen et al. • Cell Reports
(2026)
Summary: The β-barrel assembly machinery (BAM) is essential for outer membrane protein (OMP) biogenesis in Gram-negative bacteria and represents a validated target for antibiotic development. Its evolutionary relative, the translocation and...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.celrep.2026.117733
Martin Sindelar, Anna Kocurkova, Matej Simek, Pavel Roudnicky et al. • MicrobiologyOpen
(2026)
ABSTRACT The ability of gut microbes to degrade host‐ and diet‐derived glycans is central to microbiome ecology and host interactions, yet predicting these functions in silico remains challenging. Hyaluronan (HA), a glycosaminoglycan (GAG) ...
DOAJ
Open Access (DOAJ)
DOI: 10.1002/mbo3.70227
Adam H. Tencer, Jiuyang Liu, Jing Zhu, Nathaniel T. Burkholder et al. • Scientific Reports
(2022)
Abstract The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2 (HERC2ZZ) recognizes a mimetic of the Nt-R cargo ...
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Open Access (DOAJ)
DOI: 10.1038/s41598-022-10119-w
Hoda Zarkoob, Anna Allué-Guardia, Yu-Chi Chen, Andreu Garcia-Vilanova et al. • Communications Biology
(2022)
Human alveolar and tracheobronchial epithelial air liquid interface (ALI) tissues are used as models to examine cellular responses to SARS-CoV-2 and influenza A virus infections and as antiviral drug screening assay platforms....
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s42003-022-03753-7
Veronika Heinz, Wenke Jäckel, Susann Kaltwasser, Laura Cutugno et al. • Communications Biology
(2022)
A cryo-electron microscopy reconstruction of a stressosome complex from a Gram-negative bacterium, Vibrio vulnificus, reveals variations in subunit composition and symmetry, which could serve to adjust the activation threshold in the respon...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s42003-022-03548-w
Maral Rahimzadeh, Majid Sadeghizadeh, Farhood Najafi, Seyed Shahriar Arab et al. • Materials Research Express
(2020)
During the last few decades, extensive studies have been conducted to elucidate the anti-cancer effects of curcumin. Despite promising results indicating curcumin could impede cancer cells ability thrive and proliferation, clinical applicat...
DOAJ
Open Access (DOAJ)
DOI: 10.1088/2053-1591/ab770f
Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring et al. • Cancer Biology & Medicine
(2017)
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Th...
DOAJ
Open Access (DOAJ)
DOI: 10.20892/j.issn.2095-3941.2016.0086
Fernanda Bajanca, Nadège Gouignard, Charlotte Colle, Maddy Parsons et al. • Nature Communications
(2019)
Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be ...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41467-019-09548-5
Joseph Hibbeln, Steven Gregory, Yasmin Iles-Caven, Caroline M. Taylor et al. • Environment International
(2018)
There is a public perception that relatively low doses of mercury found in seafood are harmful to the fetal brain but little consistent evidence to support this. In earlier publications we have shown no adverse associations between maternal...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.envint.2018.03.024
Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw et al. • Cells
(2026)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 di...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/cells15040342
Victoria Vitkova, Vesela Yordanova, Galya Staneva, Ognyan Petkov et al. • Membranes
(2021)
Simple carbohydrates are associated with the enhanced risk of cardiovascular disease and adverse changes in lipoproteins in the organism. Conversely, sugars are known to exert a stabilizing effect on biological membranes, and this effect is...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/membranes11110847
Augusto Berrocal, Nicholas C Lammers, Hernan G Garcia, Michael B Eisen • eLife
(2020)
We used live imaging to visualize the transcriptional dynamics of the Drosophila melanogaster even-skipped gene at single-cell and high-temporal resolution as its seven stripe expression pattern forms, and developed tools to characterize an...
DOAJ
Open Access (DOAJ)
DOI: 10.7554/eLife.61635
Yashar Bashirzadeh, Hossein Moghimianavval, Allen P. Liu • iScience
(2022)
Summary: Cell shape changes from locomotion to cytokinesis are, to a large extent, driven by myosin-driven remodeling of cortical actin patterns. Passive crosslinkers such as α-actinin and fascin as well as actin nucleator Arp2/3 complex la...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.isci.2022.104236
Stefania Martucciello, Marchesa Bilio, Sara Cioffi, Ilaria Aurigemma et al. • Journal of Cardiovascular Development and Disease
(2026)
Gene inactivation in model organisms has identified numerous genes and signaling pathways involved in mammalian cardiac outflow tract (OFT) development. Human genetics data have implicated the VEGFR3 gene in OFT development, but when and wh...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/jcdd13080399
Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods
(2025)
Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/foods14234030
Eleanor Feneck, Malcolm Logan • Biomolecules
(2020)
Retinoic acid (RA) was one of the first molecules in the modern era of experimental embryology to be shown capable of generating profound effects on limb development. In this review, we focus on the earliest events of limb development and s...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/biom10020312