Academic Articles & Research Papers

Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors

Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies, achieving remarkable clinical success with FDA-approved therapies targeting CD19 and BCMA. However, the extension of these successe...

Wild immunology

In wild populations, individuals are regularly exposed to a wide range of pathogens. In this context, organisms must elicit and regulate effective immune responses to protect their health while avoiding immunopathology. However, most of our...

Immunology of Psoriasis

The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-associated lymphoid tissue (SALT). The reaction of these components to injury allows an effective cutaneo...

Pulsed Low-dose-rate Radiotherapy Remodels the Tumor Immune Microenvironment and is Associated With Crosstalk Between SPP1⁺ tumor-associated macrophages and GZMK⁺ CD8⁺ T cells.

Evaluating Genomic Testing in Pediatric Inborn Errors of Immunity: An Optimal Model of Care.

The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2 [v1; ref status: indexed, http://f1000r.es/201]

The primary function of the dsRNA binding protein (dsRBP) PACT/RAX is to activate the dsRNA dependent protein kinase PKR in response to stress signals.  Additionally, it has been identified as a component of the small RNA processing pathway...

Cardiovascular and metabolic outcomes associated with moderate-to-severe atopic dermatitis: A systematic review and meta-analysis

Background: Chronic systemic inflammation in individuals with moderate-to-severe atopic dermatitis (AD) potentially predisposes them to metabolic and cardiovascular diseases. Nevertheless, evidence with regard to such association is limited...

Global variations in funding and use of hemodialysis accesses: an international report using the ISN Global Kidney Health Atlas

Abstract Background There is a lack of contemporary data describing global variations in vascular access for hemodialysis (HD). We used the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) to ...

Current Protocols in Immunology

Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional acti...

Females Display Greater Disease Severity in a Mouse Model of Vitiligo.

Modelling Potassium Properties in East African Soils Using Infrared Spectroscopy

Potassium (K) is an essential plant nutrient and is often in short supply in the highly weathered soils of East Africa. The development of effective and sustainable fertilisation strategies could be helped by developing rapid and relatively...

Long-term exposure to air pollution and incidence risk of various arrhythmias: A prospective cohort study

To investigate the association of long-term exposure to air pollution with incident arrhythmia from various causes, this prospective cohort study included 442,386 participants from the UK Biobank cohort. Residential annual average exposures...

Carbon dioxide uptake in a eutrophic stratified reservoir: Freshwater carbon sequestration potential

Carbon capture and storage due to photosynthesis activities has been proposed as a carbon sink to mitigate climate change. To enhance such mitigation, previous studies have shown that freshwater lakes should be included in the carbon sink, ...

Uncertainties in the effects of organic aerosol coatings on polycyclic aromatic hydrocarbon concentrations and their estimated health effects

We used the CAM5 model to examine how different particle-bound polycyclic aromatic hydrocarbon (PAH) degradation approaches affect the spatial distribution of benzo(a)pyrene (BaP). Three approaches were evaluated: NOA (no effect of OA coati...

Importance of background threshold value development within risk‐based corrective action programs

Abstract Risk‐based corrective action (RBCA) programs employ conservative models to develop default values for soil screening, which simplify the risk assessment process. However, for several naturally occurring metals (e.g., arsenic and le...

Ultrasound-enhanced co-fermentation of Yunnan Arabica coffee with rose petals: Mass transfer, microbial succession, and molecular modeling.

Coal mine methane emissions quantification based on vehicle-based monitoring

Obtaining accurate emissions of methane (CH_4), one of the most important non-carbon-dioxide greenhouse gases, is the basis for formulating and validating emission reduction policies. In terms of shortcomings from the "bottom-up" approach, ...

Anaerobic Digestion, Codigestion of Food Waste, and Chicken Dung: Correlation of Kinetic Parameters with Digester Performance and On-Farm Electrical Energy Generation Potential

Valorization of agro-food waste through anaerobic digestion (AD) is gaining prominence as alternative method of waste minimization and renewable energy production. The aim of this study was to identify the key parameters for digester perfor...

Dynamic simulation of a 4th generation district heating network with the presence of prosumers

District Heating Network is identified as a promising technology for decarbonizing urban areas. Thanks to the surplus of heat available from distributed renewable energy plants, a typical heat consumer of the network could become an energy ...

The Investigation of Impact of Complement Policy for Energy Price Policy Reform on Transport Sector in Iran by Computable General Equilibrium

With regard to the ever-increasing need for energy in current societies to satisfy various requirements, scientists and researchers from different countries, such as Iran, have a basic approach in their agenda to achieve renewable energies،...