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Showing 20 of 4,465 academic articles

A Novel Prognostic Scoring Model for Myelodysplastic Syndrome Patients With SF3B1 Mutation

Liya Ma, Bin Liang, Huixian Hu, Wenli Yang et al. • Frontiers in Oncology (2022)

The outcomes of myelodysplastic syndrome (MDS) patients with SF3B1 mutation, despite identified as a favorable prognostic biomarker, are variable. To comprehend the heterogeneity in clinical characteristics and outcomes, we reviewed 140 MDS...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2022.905490

Expanding the genetic spectrum of hereditary motor sensory neuropathies in Pakistan

Asif Naveed Ahmed, Lettie E. Rawlins, Niamat Khan, Zakir Jan et al. • BMC Neurology (2024)

Abstract Background Hereditary motor and sensory neuropathy (HMSN) refers to a group of inherited progressive peripheral neuropathies characterized by reduced nerve conduction velocity with chronic segmental demyelination and/or axonal dege...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12883-024-03882-y

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

Kevin Achberger, Christopher Probst, Jasmin Haderspeck, Sylvia Bolz et al. • eLife (2019)

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.46188

Implications of Isoprostanes and Matrix Metalloproteinase-7 Having Potential Role in the Development of Colorectal Cancer in Males

Mahmood Rasool, Arif Malik, Ahmad Ashar Ghuman, Muhammad Abdul Basit Ashraf et al. • Frontiers in Oncology (2018)

BackgroundColorectal cancer (CRC) is the third most common type of cancer and leading cause of death worldwide. Major risk factors involved in the development of CRC are increased dietary sources, genetics, and increasing age. Purpose of th...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2018.00205

Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu et al. • Clinical Epigenetics (2023)

Abstract Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates protein stabil...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13148-023-01588-5

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy

Wei Liu, Yan Xu, Yi Wang, Lugui Qiu et al. • Journal for ImmunoTherapy of Cancer (2024)

Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or prog...

DOAJ Open Access (DOAJ) DOI: 10.1136/jitc-2023-008450

PRODUCTION OF L-TRYPTOPHAN BY MUTANTS OF CORYNEBACTERIUM GLUTAMICUM

Hamies Mohamed, Ghada El Nady, A. Ali, A. Abdel-Razik et al. • Arab Universities Journal of Agricultural Sciences (2018)

L-Tryptophan, is one of the amino acids, also is one of the 9 essential amino acids of human which cannot be synthesized internally by him, microbial production is the main method for obtaining tryptophan for commercial uses. Typical microo...

DOAJ Open Access (DOAJ) DOI: 10.21608/ajs.2018.28383

Comparative Phytochemical Analysis of the Aerial Parts of <i>Pelargonium radula</i> and <i>Geranium macrorrhizum</i> Cultivated in Bulgaria Using GC-MS and HPLC

Debora Sabotinova, Petya Boycheva, Nadezhda Ivanova, Velichka Andonova et al. • Pharmaceuticals (2026)

Background: Geraniaceae species are widely used in traditional medicine. Pelargonium radula and Geranium macrorrhizum are aromatic medicinal plants traditionally used in Bulgaria for their antimicrobial, anti-inflammatory, and wound-healing...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph19030346

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells

Xinbo Wang, Jiaying Miao, Sizhen Wang, Rongxi Shen et al. • Molecular Cancer (2022)

Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features. Me...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-022-01596-8

Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis

Mengqiang Fan, Peijian Tong, Li Yan, Ting Li et al. • BMC Medicine (2023)

Abstract Background Articular injection of mesenchymal stem cells (MSCs) has been applied to treat knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated whether an articular inflammatory microenviro...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12916-023-02923-6

Absence of Asymptomatic Malaria Infection in Endemic Area of Bashagard District, Hormozgan Province, Iran

H Turki, S Zoghi, A A Mehrizi, S Zakeri et al. • Iranian Journal of Parasitology (2012)

Background: A successful malaria elimination program calls for enough attention to parasite carri­ers, especially asymptomatic malaria, as well as the diagnosis and treatment of clinical cases. Asymptomatic malaria is an infection that pati...

DOAJ Open Access (DOAJ)

Medical biotechnology

Firdos Alam Khan • CRC Press eBooks (2018)

This chapter explains the role of biotechnology in medicine and explores the process of making antibodies and hybridoma technology. It shows how vaccines are manufactured and discusses the significance of stem cell therapy and the related i...

OPENALEX DOI: https://doi.org/10.1201/9781315370767-9

Relationship between Perceived Social Support in First Pregnancy with Birth Satisfaction in Primigravid Women Referred to Shahid Akbar Abadi Hospital

homa sadeghi aval shahr, sayeh sadat moosavi sahebalzamani, freshteh jahdi, leila neisani samani et al. • Preventive Care in Nursing and Midwifery Journal (2014)

Background and Objectives: Recent studies have shown that social and environmental factors as well as social communication play crucial role in pregnancy outcomes. The current study aimed to examine the relationship between perceived social...

DOAJ Open Access (DOAJ)

Maternal dietary fiber intake during pregnancy and child development: the Japan Environment and Children's Study

Kunio Miyake, Sayaka Horiuchi, Ryoji Shinohara, Megumi Kushima et al. • Frontiers in Nutrition (2023)

BackgroundAnimal studies have shown that maternal low-fiber diets during pregnancy may impair brain development and function in offspring, but this has not been validated by epidemiological studies. The aim of this study was to investigate ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2023.1203669

‘Incense is the one that keeps the air fresh’: indoor air quality perceptions and attitudes towards health risk

Ashley Williams, Kayla Schulte, Diana Varaden • BMC Public Health (2024)

Abstract Background Air pollution is of significant environmental and public health concern globally. While much research has historically focused on outdoor air pollution, indoor air pollution has been relatively under-explored despite its...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12889-024-20635-1

Parents’ Perceptions of the Problems in Children With Autism Spectrum Disorders: A Qualitative Study

Masume Zareei, Seyed Abolfazl Tohidast, Masoomeh Salmani • Iranian Rehabilitation Journal (2022)

Objectives: Parents of children with autism spectrum disorder (ASD) have valuable experiences of the possible developmental problems and other issues of their children as the primary caregivers. The present study aimed to obtain proper info...

DOAJ Open Access (DOAJ)