Academic Articles & Research Papers

Shotgun metagenomic sequencing of serum extracellular vesicle-derived DNA enables microbial profiling in urothelial carcinoma

Abstract Shotgun metagenomic sequencing provides more detailed microbial information than 16 S rRNA sequencing but requires higher cost and larger sample volumes. We evaluated whether shotgun metagenomic sequencing could detect bacterial DN...

Cancer Immunology

This review is a comprehensive account of the current status of tumor immunology, beginning with the identification of human tumor antigens and ending with a summary of clinical applications of what we know about the immunology of tumors....

Reproductive Immunology

As eloquently stated by Dr Saul R. Gusberg in the foreword toReproductive Immunology, "this volume represents a milestone, for it will establish the identity of reproductive immunology as a significant area of basic immunology and as a sign...

Nanomedicine for Glioblastoma: Cutting-Edge Advances and Persistent Challenges

Cancer is a disorder characterized by the abnormal growth of cells that increases uncontrollably over an extended period of time. Treating cancerous brain tumors remains among the most challenging tasks for researchers, as brain tumors are ...

Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer

Colorectal cancer (CRC) tends to occur at older age; however, CRC incidence rates have been rising sharply among young age groups. The increasing prevalence of obesity is recognized as a major risk, yet the mechanistic underpinnings remain ...

Molecular MRI Reveals Macrophage-Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer.

Hypoxia-Inducible Expression of Annexin A6 Enhances the Resistance of Triple-Negative Breast Cancer Cells to EGFR and AR Antagonists

Physiological changes such as hypoxia in the tumor microenvironment (TME) endow cancer cells with malignant properties, leading to tumor recurrence and rapid progression. Here, we assessed the effect of hypoxia (1% Oxygen) on the tumor supp...

Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition

Summary: Pancreatic cancer (PC) exhibits profound metabolic adaptations that support tumor progression, survival, and therapy resistance. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of these processes, promoting metabolic reprog...

Small cell neuroendocrine carcinoma of the cervix: From molecular basis to therapeutic advances

Small cell neuroendocrine carcinoma of the cervix (SCNECC) is an uncommon but aggressive uterine malignancy, the cause of which is generally associated with human papillomavirus (HPV) infection. A lack of clinical trials and evidence-based ...

Editorial: 2021 WHO classification of pediatric brain tumors: a final wedding between morphology and molecular biology?

Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes

Abstract Background Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1) and its m...

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

During tumor development and progression, intrinsic and extrinsic factors trigger endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the increased expression of molecular chaperones to cope with the stress and...

Recuperação Completa de Doente com Carcinoma da Próstata Estádio IV Durante a Pandemia COVID-19

A doença causada pelo coronavírus (COVID-19), inicialmente descrita em Wuhan, China, foi recentemente declarada pela Organização Mundial da Saúde (OMS) como uma pandemia global. A idade avançada e a presença de comorbilidades, característic...

Evaluation of the Clinical Utility of Circulating Tumor DNA in the Management of Patients With Nonmetastatic Head and Neck Cancer: Protocol for a Prospective Bicentric Study (CIRVAD).

The Effects of N-acetylcysteine on Inflammatory Markers and Homocysteine: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Background: Recently a number of trials investigated the effect of N-acetylcysteine (NAC) administration on inflammatory markers and homocysteine (Hcy). However, their findings are controversial. The aim of this paper is to present a meta-a...

Extracellular targeted protein degradation for tumor immune microenvironment reprogramming: from checkpoint blockade to checkpoint elimination.

Tumor Microenvironment-Mediated Resistance in HER2-Positive Breast Cancer: Recent Advances and Therapeutic Challenges.

Bone Metastasis and the Immunosuppressive Tumor Microenvironment: Mechanisms and Therapeutic Strategies.

Analyzing Brain Tumor Classification Techniques: A Comprehensive Survey

Classification of brain tumour is critical in medical image analysis and diagnosis as it aids in determining the affinity of cases to select treatment paths. This feature underscores the importance of accurate classification of brain tumour...

Hyperspectral imaging and machine learning in brain tumor surgery: Current evidence, clinical applications, and future directions.