MainReads

Discover Books. Explore Knowledge.

Home » Academic Articles & Research Papers

Academic Articles & Research Papers

Search and discover peer-reviewed scholarly literature, open-access articles, and research citations across DOAJ, PubMed Central, and OpenAlex.

Reset
Showing 20 of 404 academic articles

Prenatal to postnatal trajectory of brain growth in complex congenital heart disease

Cynthia M. Ortinau, Kathryn Mangin-Heimos, Joseph Moen, Dimitrios Alexopoulos et al. • NeuroImage: Clinical (2018)

Altered brain development is a common feature of the neurological sequelae of complex congenital heart disease (CHD). These alterations include abnormalities in brain size and growth that begin prenatally and persist postnatally. However, t...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2018.09.029

Concurrent acute cystitis, pancolitis, and tubo-ovarian abscess following laparoscopic ovarian cystectomy: a case report

Yazan AlHabil, Anas N. Owda, Basil J. Zaid, Seema Hameedi et al. • BMC Women's Health (2024)

Abstract Background Inadequate surgical interventions can lead to serious complications such as tubo-ovarian abscesses in the upper female genital system, often resulting from untreated pelvic inflammatory disease. Pelvic inflammatory disea...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12905-024-03341-3

Using the consolidated framework for implementation research to guide a pilot of implementing an institution level patient informed consent process for clinical research at an outpatient setting

Xuling Lin, Joanne Yong Ern Yuen, Wei Quan Jeremy Chan, Tushar Gosavi Divakar et al. • Pilot and Feasibility Studies (2023)

Abstract Background In Singapore, research teams seek informed patient consent on an ad hoc basis for specific clinical studies and there is typically a role separation between operational and research staff. With the enactment of the Human...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40814-023-01234-0

Conceptualisation and design of a protocol for a novel social drivers and primary care screening tool in paediatric orthopaedics: a quality improvement initiative

Devika A Shenoy, Kathryn Radulovacki, Christian Zirbes, Rachelle Shao et al. • BMJ Open Quality (2025)

Introduction Paediatric patients with elevated healthcare needs have limited access to care, contributing to insufficient preventive services. Social drivers of health (SDOH), such as inadequate nutrition and poor community support, contrib...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjoq-2025-003454

HFA of the ESC Position paper on the management of LVAD supported patients for the non LVAD specialist healthcare provider Part 1: Introduction and at the non‐hospital settings in the community

Binyamin Ben Avraham, Marisa Generosa Crespo‐Leiro, Gerasimos Filippatos, Israel Gotsman et al. • ESC Heart Failure (2021)

Abstract The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of the LVAD‐supported patients on the device a...

DOAJ Open Access (DOAJ) DOI: 10.1002/ehf2.13588

Clinical Features and Pathogenesis of Noma: A Narrative Review Highlighting the Emerging Strategies for Prevention and Management

Bhagyesh Sapkale, Sonali Choudhari • Journal of Clinical and Diagnostic Research (2026)

Noma, also known as cancrum oris, is a rapidly progressive gangrenous infection that affects the oral and facial tissues of malnourished children in impoverished regions, particularly in sub-Saharan Africa. The disease typically begins as a...

DOAJ Open Access (DOAJ) DOI: 10.7860/JCDR/2026/82789.22726

Evaluation of Knowledge and Self-Reported Performance of Primary School Healthcare Providers in the City of Abarkuh City Regarding the Emergency Management of Traumatic Dental Injuries

Zahra Nafisi, Adele Pouyafard, Amene Hosseini Yekani, Hamed Gheibollahi et al. • Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd (2025)

Introduction: Dental injuries are very common and negatively affect an individual's life. The effective management of emergencies in such situations depends on the knowledge of non-experts, such as healthcare providers, who are on-site duri...

DOAJ Open Access (DOAJ)

Mortality trends among hospitalised COVID-19 patients in Sweden: A nationwide observational cohort study

Kristoffer Strålin, Erik Wahlström, Sten Walther, Anna M Bennet-Bark et al. • The Lancet Regional Health. Europe (2021)

Background: It is important to know if mortality among hospitalised COVID-19 patients has changed as the pandemic has progressed. The aim of this study was to describe the dynamics over time of mortality among patients hospitalised for COVI...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.lanepe.2021.100054

Public–private partnership in pipelining science of acute care ecosystem: Insights from Taiwan's Presidential Hackathon

Chao‐Wen Chen, Yung‐Sung Yeh, Ta‐Chien Chan, Yi‐Syuan Wu • Learning Health Systems (2025)

Abstract Introduction The acute care system faced significant challenges in managing healthcare emergencies due to a lack of coordination between emergency services and logistical support. This disorganization undermined collaboration and r...

DOAJ Open Access (DOAJ) DOI: 10.1002/lrh2.10474

Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study

Fei Wang, Fei Wang, Min Fei, Min Fei et al. • Frontiers in Neuroscience (2022)

BackgroundConstipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2021.821654

Alterations in white matter fiber density associated with structural MRI and metabolic PET lesions following multimodal therapy in glioma patients

Michel Friedrich, Ezequiel Farrher, Svenja Caspers, Svenja Caspers et al. • Frontiers in Oncology (2022)

BackgroundIn glioma patients, multimodality therapy and recurrent tumor can lead to structural brain tissue damage characterized by pathologic findings in MR and PET imaging. However, little is known about the impact of different types of d...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2022.998069

Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning

Sijie Li, Sijie Li, Changhong Ren, Changhong Ren et al. • Frontiers in Genetics (2020)

Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such mol...

DOAJ Open Access (DOAJ) DOI: 10.3389/fgene.2020.582368

Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Zelin Tian, Chen Xu, Peijun Yang, Zhibin Lin et al. • Frontiers in Immunology (2022)

Hepatocellular carcinoma(HCC) is the sixth most common cancer in the world and is usually caused by viral hepatitis (HBV and HCV), alcoholic, and non-alcoholic fatty liver disease(NAFLD). Viral hepatitis accounts for 80% of HCC cases worldw...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.984728

Emerging mutations in envelope protein of SARS-CoV-2 and their effect on thermodynamic properties

Kejie Mou, Mohnad Abdalla, Dong Qing Wei, Muhammad Tahir Khan et al. • Informatics in Medicine Unlocked (2021)

Structural proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are potential drug targets due to their role in the virus life cycle. The envelope (E) protein is one of the structural proteins; plays a critical role in v...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.imu.2021.100675

Persistent Endothelial Dysfunction in Post-Acute COVID-19 Syndrome: A Case-Control Study

Pasquale Ambrosino, Ilenia Calcaterra, Antonio Molino, Pasquale Moretta et al. • Biomedicines (2021)

Background: Endothelial dysfunction has a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its disabling complications. We designed a case-control study to assess the alterations of endothelium-dependent flow-mediated...

DOAJ Open Access (DOAJ) DOI: 10.3390/biomedicines9080957

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Chih-Yang Huang, Chia-Hua Kuo, Pei-Ying Pai, Tsung-Jung Ho et al. • Data in Brief (2018)

In association with the published article “Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy” (Huang et al., 2017) [1], this data article contains information about deSUMOylat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dib.2017.11.040

Antibody response after pneumococcal vaccination in a large cohort of Italian children and adolescents with Down syndrome

Antonio Musolino, Marco Roversi, Mariateresa Romaniello, Vittorio Scoppola et al. • Vaccine: X (2025)

Introduction: Pneumococcal vaccination has significantly decreased the burden of invasive pneumococcal disease in the general population, however studies on effectiveness in Down syndrome (DS) are heterogeneous. In this cross-sectional stud...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jvacx.2025.100744

Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu et al. • Clinical Epigenetics (2023)

Abstract Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates protein stabil...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13148-023-01588-5