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Academic Articles & Research Papers
Showing 20 of 2,780 academic articles
Miriam E. Dillard, Christina A. Daly, Rojalin Pradhan, Shariq S. Ansari et al. • Nature Communications
(2026)
Abstract Sonic Hedgehog (SHH) signaling functions in temporal- and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is induced by sterols, oxysterols, and arachidonic acid (AA...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41467-026-75918-5
Sanjay Mishra, Manish Charan, Ajeet Kumar Verma, Bhuvaneswari Ramaswamy et al. • Frontiers in Cell and Developmental Biology
(2021)
Recent studies revealed that ethnic differences in mechanistic target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK-1/2) signaling pathways might be associated with the development and progression of different human mal...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fcell.2021.601929
Man Teng, Zi-Yu Zhou, Yongxiu Yao, Venugopal Nair et al. • Viruses
(2022)
Marek’s disease virus (MDV) is an important oncogenic α-herpesvirus that induces Marek’s disease (MD), characterized by severe immunosuppression and rapid-onset T-cell lymphomas in its natural chicken hosts. Historically, MD is regarded as ...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/v14092045
Jingying Zhang, Aashish Bhatt, Grigory Maksaev, Yun Lyna Luo et al. • Nature Communications
(2025)
Abstract The mechanosensitive channel of small conductance (MscS) from E. coli (EcMscS) has served as the prevailing model system for understanding mechanotransduction in ion channels. Trypanosoma cruzi, the protozoan parasite causing Chaga...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41467-025-62757-z
S. H. Ubohov, V. V. Trokhymchuk, G. V. Zagoriy, L. O. Fedorova • Фармацевтичний журнал
(2019)
One of the most promising ways to increase the efficiency of pharmaceutical enterprises in the field of quality assurance of medicines is the introduction of integrated quality systems (IQS).
The aim of the work is to study of the state ...
DOAJ
Open Access (DOAJ)
DOI: 10.32352/0367-3057.2.19.01
Angel Chao, Ren-Chin Wu, Chiao-Yun Lin, Ting-Chang Chang et al. • Biomedical Journal
(2023)
Small cell neuroendocrine carcinoma of the cervix (SCNECC) is an uncommon but aggressive uterine malignancy, the cause of which is generally associated with human papillomavirus (HPV) infection. A lack of clinical trials and evidence-based ...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.bj.2023.100633
Marjo J. den Broeder, Jarle Ballangby, Leonie M. Kamminga, Peter Aleström et al. • Epigenetics & Chromatin
(2020)
Abstract Background Recent studies indicate that exposure to environmental chemicals may increase susceptibility to developing metabolic diseases. This susceptibility may in part be caused by changes to the epigenetic landscape which conseq...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s13072-020-0329-y
Ruidong Wan, Ziqi Zhao, Min Zhao, Ke Hu et al. • Scientific Reports
(2021)
Abstract Yaks are typical plateau-adapted animals, however the microvascular changes and characteristics in their lungs after birth are still unclear. Pulmonary microvasculature characteristics and changes across age groups were analysed us...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41598-021-97760-z
Magdalena Sevilla-González, Maria Fernanda Garibay-Gutiérrez, Arsenio Vargas-Vázquez, Andrea Celeste Medina-García et al. • Current Developments in Nutrition
(2024)
Background: A risk haplotype in SLC16A11 characterized by alterations in fatty acid metabolism emerged as a genetic risk factor associated with increased susceptibility to type 2 diabetes (T2D) in Mexican population. Its role on treatment r...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.cdnut.2024.104444
Zhiming Feng, Zhiming Feng, Mingyou Li, Zhiwen Xu et al. • Frontiers in Plant Science
(2022)
Rice blast, caused by Magnaporthe oryzae (M. oryzae), is one of the most destructive diseases threatening rice production worldwide. Development of resistant cultivars using broad-spectrum resistance (R) genes with high breeding value is th...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fpls.2022.937767
Naoya Matsumoto, Abhigyan Satyam, Mayya Geha, Mayya Geha et al. • Frontiers in Immunology
(2017)
C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied....
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fimmu.2017.01046
Shuhei Yoshida, Haruki Matsumoto, Jumpei Temmoku, Norshalena Shakespear et al. • Frontiers in Immunology
(2023)
Temporal arteritis (TA) is a large-vessel vasculitis mostly seen in older patients. Amyloid A (AA) amyloidosis secondary to a chronic inflammation induces multiple organ dysfunctions, including a dysfunction of the gastrointestinal tract. H...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fimmu.2023.1144397
Cansin Sackesen, Derya Ufuk Altintas, Aysen Bingol, Gulbin Bingol et al. • Frontiers in Pediatrics
(2019)
This review addresses the current strategies of inducing tolerance development in infant and childhood cow's milk protein allergy (CMPA). The change in prevention strategies for CMPA has been emphasized based on the lack of evidence to supp...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fped.2019.00372
Cecelia Kelly, Irene Salinas • Frontiers in Immunology
(2017)
Commensal microorganisms inhabit every mucosal surface of teleost fish. At these surfaces, microorganisms directly and indirectly shape the teleost immune system. This review provides a comprehensive overview of how the microbiota and micro...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fimmu.2017.00559
Eva Klingberg, Maria K. Magnusson, Hans Strid, Anna Deminger et al. • Arthritis Research & Therapy
(2019)
Abstract Background Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogen...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s13075-019-2018-4
Qingwei Wu, Zhifa Ge, Chengyu Lv, Qifeng He • Frontiers in Immunology
(2025)
Autoimmune hepatitis (AIH) is a progressive liver inflammatory disease mediated by an autoimmune response, with an increasing incidence rate. In severe cases, AIH will rapidly progress to liver cirrhosis and liver failure and even lead to d...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fimmu.2025.1584001
Xiaofeng Duan, Stephen Iwanowycz, Soo Ngoi, Megan Hill et al. • Frontiers in Oncology
(2021)
During tumor development and progression, intrinsic and extrinsic factors trigger endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the increased expression of molecular chaperones to cope with the stress and...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fonc.2021.629846
Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G. Tolman et al. • Disease Models & Mechanisms
(2020)
Glaucoma is a leading cause of blindness, affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. It is well established that inefficient aqueous humor (AqH) outflow resulting from s...
DOAJ
Open Access (DOAJ)
DOI: 10.1242/dmm.042853
Yvonne Tan, Danielle Pinder, Imaan Bayoumi, Rifaa Carter et al. • International Journal for Equity in Health
(2024)
Abstract Background Adverse childhood experiences (ACEs), in combination with adverse community environments, can result in traumatic stress reactions, increasing a person’s risk for chronic physical and mental health conditions. Family res...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s12939-024-02142-2
Sarah Samuelson, Eva-Lisa Petersson, Cecilia Björkelund, Marcus Praetorius Björk et al. • BMC Health Services Research
(2026)
Abstract Background Innovation is increasingly necessary in primary care policy, and healthcare managers play a pivotal role in translating policy ambitions into practice and shaping organisational conditions that foster innovation. The aim...
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Open Access (DOAJ)
DOI: 10.1186/s12913-026-14870-y