Academic Articles & Research Papers

Nature of Paleozoic Basement of the Catalan Coastal Ranges (Spain) and Tectonic Setting of the Priorat DOQ Wine Terroir: Evidence from Volcanic and Sedimentary Rocks

The Paleozoic volcano-sedimentary rocks within the structural basement of the horst-and-graben system of the Catalan Coastal Ranges (CCR) are composed of black shale, volcaniclastic sediments, lava flows, sills and lithocrystalloclastic tuf...

Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible <it>IRF1 </it>gene

Abstract Background The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription effected by s...

Corrigendum: The Potential Roles of Very Low Calorie, Very Low Calorie Ketogenic Diets and Very Low Carbohydrate Diets on the Gut Microbiota Composition

A pilot study of mitochondrial genomic ancestry in admixed Brazilian patients with type 1 diabetes

Abstract Interactions between multiple genes and environmental factors could be related to the pathogenesis of type 1 diabetes (T1D). The Brazilian population results from different historical miscegenation events, resulting in a highly div...

Cadmium sulfide-induced toxicity in the cortex and cerebellum: In vitro and in vivo studies

Living organisms have an innate ability to regulate the synthesis of inorganic materials, such as bones and teeth in humans. Cadmium sulfide (CdS) can be utilized as a quantum dot that functions as a unique light-emitting semiconductor nano...

Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndrome

Pheochromocytomas (PCCs) are rare but potentially lethal tumors that arise from the adrenal medulla. The clinical suspicion and diagnosis of PCC can be challenging due to the non-specific nature of signs and symptoms. In many patients, infe...

Beverage Consumption Patterns and Their Association with Metabolic Health in Adults from Families at High Risk for Type 2 Diabetes in Europe—The Feel4Diabetes Study

In total, 3274 adults (65.2% females) from six European countries were included in this cross-sectional analysis using data from the baseline assessment of the Feel4Diabetes study. Anthropometric, sociodemographic, dietary and behavioral da...

Alleviation effect of glycyrrhetinic acid on zearalenone-induced reproductive toxicity in replacement gilts

IntroductionThis study investigated whether glycyrrhetinic acid (GA) can alleviate the reproductive toxicity of Zearalenone (ZEN) in replacement gilts.MethodsEighty Landrace × Yorkshire gilts were randomly assigned to four dietary groups: c...

DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort

BackgroundObesity and frailty are prevalent geriatric conditions that share some pathophysiological mechanisms and are associated with adverse clinical outcomes. The relationship between frailty, obesity, and polymorphism remains inadequate...

VirtualToxLab™ - In silico prediction of the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. Two years and 2,000 compounds of experience: a progress report

The VirtualToxLab™ is an in silico tool for predicting the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. It is based on a fully automated protocol and calculates the binding affinity of any molecule of int...

Perception of diagnosis by family caregivers in severe brain injury patients in China

Abstract Objectives Surrogate decision-making by family caregivers for patients with severe brain injury is influenced by the availability and understanding of relevant information and expectations for future rehabilitation. We aimed to com...

Translational research in health technologies: A scoping review

Introduction: The current debate on the process of technological innovation points out as a challenge for universities consolidation of competencies that allow the generation and transfer of knowledge to society. The Translational Research ...

Psychological STress, Anxiety, and Depression After miscarriage in comparison to successful pregnancy and abortion: design and protocol for the observational cohort study STRADA

Introduction Miscarriage occurs in 15%–20% of clinically recognised pregnancies. It may cause acute or prolonged psychological distress such as anxiety, depression and post-traumatic stress disorder (PTSD). Data on symptom severity and dura...

Avoiding health technology assessment: a global survey of reasons for not using health technology assessment in decision making

INTRODUCTION: Despite the documented benefits of using health technology assessments (HTA) to inform resource allocation in health care systems, HTA remains underused, especially in low- and middle-income countries. A survey of global healt...

Health Technology Assessment

Abstract This chapter explores how health technology assessment (HTA) has evolved and the role of patient involvement in it. HTA seeks to inform decision-makers about the value of a health technology through a systematic process that assess...

Serum amyloid beta 42 levels correlated with metabolic syndrome and its components

IntroductionBeta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer’s disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-β pe...

Depressive phenotype shapes behavioral, neuroendocrine and molecular responses to repetitive transcranial magnetic stimulation in preclinical models of depression

IntroductionRepetitive transcranial magnetic stimulation (rTMS) is an established non-invasive treatment for treatment-resistant depression (TRD), yet its neurobiological mechanisms remain only partially understood. We investigated whether ...

Health Technology and Reproduction

Kathleen M. Hoeger, MD, MPH Terhi T. Piltonen, MD, PhD The current issue of Seminars in Reproductive Medicine is devoted to a review of the burgeoning role of health technology in the field of reproductive medicine. The guest editor for the...

Hypermethylated PCDHGB7 as a universal cancer only marker and its application in early cervical cancer screening

Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment

Methadone maintenance treatment (MMT) remains the cornerstone for the management of opiate abuse. However, MMT can be associated with complex factors, including complications during the tolerance phase, the inability of some patients to mai...