Academic Articles & Research Papers

Incidence of suicidality in people with depression over a 10-year period treated by a large UK mental health service provider

We describe the incidence of suicidality (2007–2017) in people with depression treated by secondary mental healthcare services at South London and Maudsley NHS Trust (n = 26 412). We estimated yearly incidence of ‘suicidal ideation’ and ‘hi...

End-of-life decisions and involvement of Physical and Rehabilitation Medicine Physicians in Europe

Objective: As Physical and Rehabilitation Medicine physicians are experts in functional prognoses of disabling health conditions, the aim of this study was to gain insight into their involvement in end-of-life decisions in patients with neu...

Neudesin is involved in anxiety behavior: structural and neurochemical correlates

Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (mot...

Perceived Intensity and Discrimination Ability for Lingual Electrotactile Stimulation Depends on Location and Orientation of Electrodes

Malfunctioning sensory systems can severely impact quality of life and repair is not always possible. One solution, called sensory substitution, is to use another sensory system to bring lost information to the brain. This approach often in...

Editorial: Optical imaging and neurorehabilitation strategies after stroke

Behavior Responses to Chemical and Optogenetic Stimuli in Drosophila Larvae

An animal’s ability to navigate an olfactory environment is critically dependent on the activities of its first-order olfactory receptor neurons (ORNs). While considerable research has focused on ORN responses to odorants, the mechanisms by...

Hypoxia-Inducible Expression of Annexin A6 Enhances the Resistance of Triple-Negative Breast Cancer Cells to EGFR and AR Antagonists

Physiological changes such as hypoxia in the tumor microenvironment (TME) endow cancer cells with malignant properties, leading to tumor recurrence and rapid progression. Here, we assessed the effect of hypoxia (1% Oxygen) on the tumor supp...

Variation in TMEM106B in chronic traumatic encephalopathy

Abstract The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodege...

The influence of catch trials on the consolidation of motor memory in force field adaptation tasks

In computational neuroscience it is generally accepted that human motor memory contains neural representations of the physics of the musculoskeletal system and the objects in the environment. These representations are called internal models...

Editorial: 2021 WHO classification of pediatric brain tumors: a final wedding between morphology and molecular biology?

A Novel Depression Rehabilitation Game Framework Using VR Based on Neurofeedback

At present,depression is treated with antidepressant drugs and assisted with psychotherapy and physical therapy,and these expensive and time-consuming treatment methods often end prematurely and result in a prolonged course without effectiv...

A Fully Adapted Headstage With Custom Electrode Arrays Designed for Electrophysiological Experiments

Electrophysiological recordings lead amongst the techniques that aim to investigate the dynamics of neural activity sampled from large neural ensembles. However, the financial costs associated with the state-of-the-art technology used to ma...

Three-dimensional in vitro models for assessing temozolomide sensitivity in glioblastoma.

Artificial intelligence in clinical medicine: a state-of-the-art overview of systematic reviews with methodological recommendations for improved reporting

Medicine has become increasingly receptive to the use of artificial intelligence (AI). This overview of systematic reviews (SRs) aims to categorise current evidence about it and identify the current methodological state of the art in the fi...

Temporal confounds emulate multivariate fMRI measures of perceptual learning.

A bibliometric analysis of Piezo2 channel research.

NeuroBlu, an electronic health record (EHR) trusted research environment (TRE) to support mental healthcare analytics with real-world data

Purpose NeuroBlu is a real-world data (RWD) repository that contains deidentified electronic health record (EHR) data from US mental healthcare providers operating the MindLinc EHR system. NeuroBlu enables users to perform statistical analy...

Interpreting and improving natural-language processing (in machines) with natural language-processing (in the brain)

Neural networks models for NLP are typically implemented without the explicit encoding of language rules and yet they are able to break one performance record after another. This has generated a lot of research interest in interpreting the ...

The fluency-based semantic network of LLMs differs from humans

Modern Large Language Models (LLMs) exhibit complexity and granularity similar to humans in the field of natural language processing, challenging the boundaries between humans and machines in language understanding and creativity. However, ...

Integrative functional optical imaging approaches: Optics, microfluidics, and machine learning for neuroscience in organoids and small-animal models.