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Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Noela Rodriguez-Losada, Noela Rodriguez-Losada, Rune Wendelbob, M. Carmen Ocaña et al. • Frontiers in Neuroscience (2020)

Emerging scaffold structures made of carbon nanomaterials, such as graphene oxide (GO) have shown efficient bioconjugation with common biomolecules. Previous studies described that GO promotes the differentiation of neural stem cells and ma...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2020.570409

Sexual Dimorphism in Growth Rate and Gene Expression Throughout Immature Development in Wild Type Chrysomya rufifacies (Diptera: Calliphoridae) Macquart

Meaghan L. Pimsler, Meaghan L. Pimsler, Meaghan L. Pimsler, Carl E. Hjelmen et al. • Frontiers in Ecology and Evolution (2021)

Reliability of forensic entomology analyses to produce relevant information to a given case requires an understanding of the underlying arthropod population(s) of interest and the factors contributing to variability. Common traits for analy...

DOAJ Open Access (DOAJ) DOI: 10.3389/fevo.2021.696638

The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation

Feng Li, Tsz Y. Lo, Leann Miles, Qin Wang et al. • Nature Communications (2021)

The Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery....

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-021-24131-7

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts

Camila Fabiani, Camila Fabiani, Silvia S. Antollini, Silvia S. Antollini • Frontiers in Cellular Neuroscience (2019)

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with satu...

DOAJ Open Access (DOAJ) DOI: 10.3389/fncel.2019.00309

Green synthesis, characterization and functional validation of bio-transformed selenium nanoparticles

S. Vasanthakumar, M. Manikandan, Muthu Arumugam • Biochemistry and Biophysics Reports (2024)

Selenium, an essential micronutrient with potent anticancer and antioxidant properties, the inorganic form of selenium is highly toxic, while organic and elemental nanoforms are more bioavailable and less toxic and have gained attention owi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.bbrep.2024.101760

Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability

Yuxiong Lu, Junichi Maruyama, Keiko Kuwata, Hiroyuki Fukuda et al. • Biochemistry and Biophysics Reports (2018)

Doublecortin-like kinase 1 (DCLK1) is a serine/threonine-kinase with two doublecortin (DCX) domains. DCLK1 is associated with microtubules via DCX domains and regulates microtubule polymerization. DCLK1 is known to be expressed in cancer st...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.bbrep.2018.10.014

Paraffinic oil residues after heating as a basis for fuel

Zvereva Elvira, Makarova Anastasiya, Ilyin Nikolay, Ageeva Marina et al. • E3S Web of Conferences (2023)

The possibility of reuse of heavy residues (oily sludge) of low-sulfur, highly paraffinic Mangyshlak oils as a basis for fuel with improved environmental characteristics for engines to marine, river and railway transport, gas turbine and bo...

DOAJ Open Access (DOAJ) DOI: 10.1051/e3sconf/202337604020

tRNA sequences can assemble into a replicator

Alexandra Kühnlein, Simon A Lanzmich, Dieter Braun • eLife (2021)

Can replication and translation emerge in a single mechanism via self-assembly? The key molecule, transfer RNA (tRNA), is one of the most ancient molecules and contains the genetic code. Our experiments show how a pool of oligonucleotides, ...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.63431

Advances in Imaging and Physiology-Guided Personalized Care in Acute Respiratory Distress Syndrome

Lucas Rodrigues Moraes, Pedro Leme Silva, Denise Battaglini, Patricia Rieken Macedo Rocco • Medicina (2026)

Acute respiratory distress syndrome (ARDS) is a heterogeneous inflammatory lung injury marked by increased alveolar–capillary permeability, reduced respiratory system compliance, and impaired gas exchange. Despite advances in supportive car...

DOAJ Open Access (DOAJ) DOI: 10.3390/medicina62020420

Polymer brush in articular cartilage lubrication: Nanoscale modelling and simulation

Nobuhiko Kajinami, Mitsuhiro Matsumoto • Biophysics and Physicobiology (2019)

Human knee joints move smoothly under high load conditions due to articular cartilage and synovial fluid. Much attention is paid to the role of proteoglycans. It is suggested that a part of proteoglycan forms aggregate on the cartilage surf...

DOAJ Open Access (DOAJ) DOI: 10.2142/biophysico.16.0_466

Revisiting Hyaluronan Catabolism in Bacteroides: Pathway Conservation, Overlooked Proteins, and Predictive Accuracy

Martin Sindelar, Anna Kocurkova, Matej Simek, Pavel Roudnicky et al. • MicrobiologyOpen (2026)

ABSTRACT The ability of gut microbes to degrade host‐ and diet‐derived glycans is central to microbiome ecology and host interactions, yet predicting these functions in silico remains challenging. Hyaluronan (HA), a glycosaminoglycan (GAG) ...

DOAJ Open Access (DOAJ) DOI: 10.1002/mbo3.70227

Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents

Hoda Zarkoob, Anna Allué-Guardia, Yu-Chi Chen, Andreu Garcia-Vilanova et al. • Communications Biology (2022)

Human alveolar and tracheobronchial epithelial air liquid interface (ALI) tissues are used as models to examine cellular responses to SARS-CoV-2 and influenza A virus infections and as antiviral drug screening assay platforms....

DOAJ Open Access (DOAJ) DOI: 10.1038/s42003-022-03753-7

The Vibrio vulnificus stressosome is an oxygen-sensor involved in regulating iron metabolism

Veronika Heinz, Wenke Jäckel, Susann Kaltwasser, Laura Cutugno et al. • Communications Biology (2022)

A cryo-electron microscopy reconstruction of a stressosome complex from a Gram-negative bacterium, Vibrio vulnificus, reveals variations in subunit composition and symmetry, which could serve to adjust the activation threshold in the respon...

DOAJ Open Access (DOAJ) DOI: 10.1038/s42003-022-03548-w

Application of a novel pH-responsive gemini surfactant for delivery of curcumin molecules

Maral Rahimzadeh, Majid Sadeghizadeh, Farhood Najafi, Seyed Shahriar Arab et al. • Materials Research Express (2020)

During the last few decades, extensive studies have been conducted to elucidate the anti-cancer effects of curcumin. Despite promising results indicating curcumin could impede cancer cells ability thrive and proliferation, clinical applicat...

DOAJ Open Access (DOAJ) DOI: 10.1088/2053-1591/ab770f

Roles of Rap1 signaling in tumor cell migration and invasion

Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring et al. • Cancer Biology & Medicine (2017)

Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Th...

DOAJ Open Access (DOAJ) DOI: 10.20892/j.issn.2095-3941.2016.0086

Total mercury exposure in early pregnancy has no adverse association with scholastic ability of the offspring particularly if the mother eats fish

Joseph Hibbeln, Steven Gregory, Yasmin Iles-Caven, Caroline M. Taylor et al. • Environment International (2018)

There is a public perception that relatively low doses of mercury found in seafood are harmful to the fetal brain but little consistent evidence to support this. In earlier publications we have shown no adverse associations between maternal...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.envint.2018.03.024

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V Variants

Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw et al. • Cells (2026)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 di...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells15040342

Dielectric Properties of Phosphatidylcholine Membranes and the Effect of Sugars

Victoria Vitkova, Vesela Yordanova, Galya Staneva, Ognyan Petkov et al. • Membranes (2021)

Simple carbohydrates are associated with the enhanced risk of cardiovascular disease and adverse changes in lipoproteins in the organism. Conversely, sugars are known to exert a stabilizing effect on biological membranes, and this effect is...

DOAJ Open Access (DOAJ) DOI: 10.3390/membranes11110847