Academic Articles & Research Papers

The Cognitive Neurosciences

The fifth edition of a work that defines the field of cognitive neuroscience, with entirely new material that reflects recent advances in the field. Each edition of this classic reference has proved to be a benchmark in the developing field...

The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing...

Persistent Endothelial Dysfunction in Post-Acute COVID-19 Syndrome: A Case-Control Study

Background: Endothelial dysfunction has a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its disabling complications. We designed a case-control study to assess the alterations of endothelium-dependent flow-mediated...

Computational Tools; Indispensable Armamentarium of Medical Biotechnology

Objective: Computational infrastructure of medical biotechnology provides insight into elements of genomics, proteomics for understanding diseases and biological systems in a more comprehensive and systematic way. The present study exclusiv...

Subject and Course Guides: Medical Biotechnology: Research Databases

A compilation of resources for researchers, faculty, and students in the Medical Biotechnology Program....

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

In association with the published article “Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy” (Huang et al., 2017) [1], this data article contains information about deSUMOylat...

Antibody response after pneumococcal vaccination in a large cohort of Italian children and adolescents with Down syndrome

Introduction: Pneumococcal vaccination has significantly decreased the burden of invasive pneumococcal disease in the general population, however studies on effectiveness in Down syndrome (DS) are heterogeneous. In this cross-sectional stud...

Patent licensing in medical biotechnology

Medical Biotechnology Quick Overview

The Entrez system allows users to search and get information from 37 different databases. The E-utilities serve as the Entrez system's programming interface. Biotechnology is a vast field of biology that involves the development or manufact...

Isolation, characterization, and genomic analysis of a novel phage WSPA with lytic activity against Serratia marcescens

ABSTRACT Serratia marcescens is an established pathogen implicated in hospital-acquired infections and is notorious for its propensity to form biofilms on medical devices, leading to persistent environmental contamination and increased infe...

Current Evidence on Gene-Based and Epigenetic Therapeutic, Diagnostic, and Prognostic Strategies in Epithelial-Derived Carcinomas: A Scoping Review

Background: Epithelial-derived carcinomas exhibit genomic instability due to genetic mutation and epigenetic dysregulation. Mechanisms such as DNA methylation, histone modifications, and noncoding RNA regulation may lead to tumor progressio...

Lipidomic Analysis of Caenorhabditis elegans Embryos

Metabolomic is an emerging field of system biology. Lipidomic, a branch of metabolomic, aims to characterize lipophilic metabolites in biological systems. Caenorhabditis elegans (C. elegans) is a genetically tractable and versatile animal m...

Economic Considerations in Medical Biotechnology

The biotechnology revolution has coincided with another revolution in health care: the emergence of finance and economics as major issues in the use and success of new medical technologies. Health care finance has become a major social issu...

CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy

Abstract Cell division cycle 25 (CDC25) phosphatases serve as crucial regulators of cell cycle phase transitions and essential components of the checkpoint machinery involved in DNA damage response. Emerging evidence indicates the oncogenic...

Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy

Abstract Background Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, therapy-refractory condition driven by ferroptotic disruption of jawbone-derived mesenchymal stem cells (MSCs) biology. We dissect this mechanism to va...

Anti-Tick-Borne Encephalitis Virus Activity of Novel Uridine Glycoconjugates Containing Amide or/and 1,2,3-Triazole Moiety in the Linker Structure

Tick-borne encephalitis virus (TBEV) transmitted by ticks is a pathogen of great medical importance. As still no effective antiviral treatment is available, in the present study, a series of uridine glycoconjugates containing amide or/and 1...

Expression Profiles of IGF1, EGF, and FGF2 Genes in Patients With Prostate Cancer in Isfahan Province, Iran

Background: Prostate cancer is the second most prevalent cancer among men all over the world. Over the past 10 years, prostate cancer prevalence has increased in Iran. Growth factors have an important role in the regulation and growth of ma...

Investigating the genetic makeup of the major histocompatibility complex (MHC) in the United Arab Emirates population through next-generation sequencing

Abstract The Human leukocyte antigen (HLA) molecules are central to immune response and have associations with the phenotypes of various diseases and induced drug toxicity. Further, the role of HLA molecules in presenting antigens significa...

Poly (ADP-ribose) Polymerase Promoter Hypermethylation Predispose Females to Breast Cancer

Being the most common cause of female deaths worldwide, breast cancer (BC) is intensively studied over the last two decades. In the present investigation, we evaluated the promoter methylation of three cancer-related genes; PARP-1, p21, and...

International Journal of Medical Biotechnology & Genetics

International Journal of Medical Biotechnology & Genetics (IJMBG) ISSN: 2379-1020 is a comprehensive, peer reviewed journal devoted to Medical Biotechnology and Genetics. publishes original research, latest developments, review papers, scie...