Reset
Showing 20 of 3,028 academic articles

Study of the state of readiness of pharmaceutical institutions of Ukraine for implementation of integrated quality systems

S. H. Ubohov, V. V. Trokhymchuk, G. V. Zagoriy, L. O. Fedorova • Фармацевтичний журнал (2019)

One of the most promising ways to increase the efficiency of pharmaceutical enterprises in the field of quality assurance of medicines is the introduction of integrated quality systems (IQS). The aim of the work is to study of the state ...

DOAJ Open Access (DOAJ) DOI: 10.32352/0367-3057.2.19.01

Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis

Ching-Yun Wang, Shiuan-Chen Lin, Kao-Jung Chang, Han-Ping Cheong et al. • Heliyon (2024)

Acute myeloid leukemia (AML) establishes an immunosuppressive microenvironment that favors leukemic proliferation. The immune-suppressive cytokines altered antigen processing, and presentation collectively assist AML cells in escaping cytot...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e39731

High‐Sensitivity Cardiac Troponin I and T Response Following Strenuous Activity is Attenuated by Smokeless Tobacco: NEEDED (North Sea Race Endurance Exercise Study) 2014

Julia Brox Skranes, Øyunn Kleiven, Kristin Moberg Aakre, Øyvind Skadberg et al. • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (2020)

Background Use of snus, a smokeless tobacco product, is increasing in Scandinavia. Strenuous physical activity is associated with an acute increase in high‐sensitivity cardiac troponin (swhs‐cTn) concentrations. Current smoking is associate...

DOAJ Open Access (DOAJ) DOI: 10.1161/JAHA.120.017363

Variation in TMEM106B in chronic traumatic encephalopathy

Jonathan D. Cherry, Jesse Mez, John F. Crary, Yorghos Tripodis et al. • Acta Neuropathologica Communications (2018)

Abstract The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodege...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40478-018-0619-9

The influence of catch trials on the consolidation of motor memory in force field adaptation tasks

Anne eFocke, Christian eStockinger, Christina eDiepold, Marco eTaubert et al. • Frontiers in Psychology (2013)

In computational neuroscience it is generally accepted that human motor memory contains neural representations of the physics of the musculoskeletal system and the objects in the environment. These representations are called internal models...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyg.2013.00479

Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition

Susheel Kumar Nethi, Venugopal Gunda, Nagabhishek Sirpu Natesh, Brianna M. White et al. • iScience (2025)

Summary: Pancreatic cancer (PC) exhibits profound metabolic adaptations that support tumor progression, survival, and therapy resistance. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of these processes, promoting metabolic reprog...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.isci.2025.114088

Induced Pluripotent Stem Cells (iPSCs)—Roles in Regenerative Therapies, Disease Modelling and Drug Screening

Mourad A. M. Aboul-Soud, Alhusain J. Alzahrani, Amer Mahmoud • Cells (2021)

The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution to the field of regenerative medicine, paving way for identifying the true potential of human embryonic stem cells (ESCs). Since the controversy aro...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells10092319

Linkage disequilibrium in wild mice.

Cathy C Laurie, Deborah A Nickerson, Amy D Anderson, Bruce S Weir et al. • PLoS Genetics (2007)

Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causati...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pgen.0030144

Interacting roles of gut microbiota and T cells in the development of autoimmune hepatitis

Qingwei Wu, Zhifa Ge, Chengyu Lv, Qifeng He • Frontiers in Immunology (2025)

Autoimmune hepatitis (AIH) is a progressive liver inflammatory disease mediated by an autoimmune response, with an increasing incidence rate. In severe cases, AIH will rapidly progress to liver cirrhosis and liver failure and even lead to d...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2025.1584001

Bio-Engineered Graphene-Based Cage for Efficient Local Enrichment and Biodegradation of Aqueous Organic Wastes

Jixiang Fan, Dongyun Chen, Najun Li, Qingfeng Xu et al. • Scientific Reports (2017)

Abstract Microorganism immobilization has attracted great attention as a traditional method to overcome aqueous organic wastes containing N, N-dimethylformamide (DMF). In this approach, graphene oxide was modified with functional polymer fi...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-017-01539-0

Microenvironment‐adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm‐associated diabetic chronic wound healing cascade

Lei Chen, Mengna Peng, Wei He, Xiaoli Hu et al. • Aggregate (2024)

Abstract The presence of bacterial biofilms and the occurrence of excessive inflammatory response greatly imped the healing process of chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues...

DOAJ Open Access (DOAJ) DOI: 10.1002/agt2.640

Exploring innovation landscapes: a national cross-sectional study of Swedish primary care from the viewpoint of primary care managers

Sarah Samuelson, Eva-Lisa Petersson, Cecilia Björkelund, Marcus Praetorius Björk et al. • BMC Health Services Research (2026)

Abstract Background Innovation is increasingly necessary in primary care policy, and healthcare managers play a pivotal role in translating policy ambitions into practice and shaping organisational conditions that foster innovation. The aim...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12913-026-14870-y

Improving the Transferability of Suspended Solid Estimation in Wetland and Deltaic Waters with an Empirical Hyperspectral Approach

Daniel Jensen, Marc Simard, Kyle Cavanaugh, Yongwei Sheng et al. • Remote Sensing (2019)

The deposition of suspended sediment is an important process that helps wetlands accrete surface material and maintain elevation in the face of sea level rise. Optical remote sensing is often employed to map total suspended solids (TSS), th...

DOAJ Open Access (DOAJ) DOI: 10.3390/rs11131629

A Novel Depression Rehabilitation Game Framework Using VR Based on Neurofeedback

CAI Hanshu,WANG Ziyang,ZHANG Yanhao,CHEN Yunfei,HU Bi • Jisuanji gongcheng (2018)

At present,depression is treated with antidepressant drugs and assisted with psychotherapy and physical therapy,and these expensive and time-consuming treatment methods often end prematurely and result in a prolonged course without effectiv...

DOAJ Open Access (DOAJ) DOI: 10.19678/j.issn.1000-3428.0050904

Microstructure-based variational deep material networks for robust uncertainty quantification in materials digital twins

Andreas E. Robertson, Samuel B. Inman, Ashley T. Lenau, Ricardo A. Lebensohn et al. • npj Computational Materials (2026)

Abstract Aleatoric uncertainties – irremovable variability in microstructure morphology, constituent behavior, and processing conditions – pose a major challenge to developing uncertainty-robust digital twins. We introduce the Variational D...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41524-026-02054-5

Technology-Supported Behavior Change—Applying Design Thinking to mHealth Application Development

Ramona Schweitzer, Stephan Schlögl, Marco Schweitzer • European Journal of Investigation in Health, Psychology and Education (2024)

Non-communicable diseases are the leading cause of global deaths. The risk of their development and progression is increased by modifiable behavioral risk factors. Yet, despite the known benefits of primary and secondary prevention, people ...

DOAJ Open Access (DOAJ) DOI: 10.3390/ejihpe14030039

Proposing New Data Whitening Method through Application of LSTM Method for Fault Condition Prediction in Bearing Data

Nasrin Rezaei, Andreas Rehkopf • Advances in Engineering and Intelligence Systems (2026)

In the context of big data, data preprocessing, especially data whitening, plays a pivotal role in improving the effectiveness of AI models. While traditional whitening methods suffer from severe computational bottlenecks, arising from the ...

DOAJ Open Access (DOAJ) DOI: 10.22034/aeis.2026.575941.1510

MAINSTREAMING METADATA INTO RESEARCH WORKFLOWS TO ADVANCE REPRODUCIBILITY AND OPEN GEOGRAPHIC INFORMATION SCIENCE

J. Holler, P. Kedron • The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2022)

Reproducible open science with FAIR data sharing principles requires research to be disseminated with open data and standardised metadata. Researchers in the geographic sciences may benefit from authoring and maintaining metadata from the e...

DOAJ Open Access (DOAJ) DOI: 10.5194/isprs-archives-XLVIII-4-W1-2022-201-2022

The JWST Resolved Stellar Populations Early Release Science Program. VIII. The Spatially Resolved Star Formation History of WLM

Roger E. Cohen, Kristen B. W. McQuinn, Alessandro Savino, Max J. B. Newman et al. • The Astrophysical Journal (2025)

Radial stellar population gradients within dwarf galaxies provide a promising avenue for disentangling the drivers of galaxy evolution, including environment. Within the Local Volume, radial stellar age gradient slopes correlate with intera...

DOAJ Open Access (DOAJ) DOI: 10.3847/1538-4357/adb61d