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Showing 20 of 412 academic articles

Simultaneous analysis of creatinine and uric acid in human urine samples using mean centering, ratio subtraction, and derivative spectrophotometric techniques as a green analytical protocol

Dashty K. Ali, Hemn A. Qader, Nabil A. Fakhre • Green Analytical Chemistry (2025)

Four rapid, accurate, and straightforward derivative spectrophotometric methods were developed to quantify a binary mixture of creatinine (CRT) and uric acid (UA) in human urine samples. The first technique was based on a zero-crossing tech...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.greeac.2025.100289

Detection Techniques for Synthetic Cannabinoids in Body Fluids and Tissues: A Systematic Review

Sachil Kumar, Tulsidas R. Baggi • Journal of Forensic Science and Medicine (2026)

Synthetic cannabinoids (SCs), originally developed for research purposes in the 1960s, have emerged as a significant concern in clinical and forensic toxicology due to their widespread abuse and unpredictable toxicological effects. These co...

DOAJ Open Access (DOAJ) DOI: 10.4103/jfsm.jfsm_128_25

Development and Comprehensive Diverse-Matrix Evaluation of Four PAHs Using Solvent-Modified QuEChERS-GC-MS with Freeze-Out

Kyung-Jik Lim, Hyun-Jun Kim, Yu-Jin Heo, Han-Seung Shin • Foods (2025)

Polycyclic aromatic hydrocarbons (PAHs) are recognized carcinogens that enter the food chain through pre-existing environmental contamination (air, water, soil), and their formation and accumulation during food preparation and processing in...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14172979

TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease

Eva Steinke, Eva Steinke, Eva Steinke, Olaf Sommerburg et al. • Frontiers in Medicine (2023)

BackgroundLung disease as major cause for morbidity in patients with cystic fibrosis (CF) starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype but other contributing factors are not well delineated...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.1034290

Group-format, peer-facilitated mental health promotion interventions for students in higher education settings: a scoping review protocol

Carrie Brooke-Sumner, Yandisa Sikweyiya, Mercilene T Machisa, Pinky Mahlangu • BMJ Open (2024)

Introduction Young people in higher education face various stressors that can make them vulnerable to mental ill-health. Mental health promotion in this group therefore has important potential benefits. Peer-facilitated and group-format int...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2023-080629

Protocol to measure human IL-6 secretion from CAR T cell-primed macrophage and monocyte lineage cells in vitro and in vivo using humanized mice

Thao Nguyen, Toshiaki Yoshikawa, Yusuke Ito, Hitomi Kasuya et al. • STAR Protocols (2024)

Summary: Chimeric antigen receptor (CAR) T cell therapy often causes serious toxicities, such as cytokine release syndrome (CRS), mainly due to interleukin-6 (IL-6) secreted by monocyte lineage cells. Here, we describe a protocol to generat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.xpro.2024.103423

The Challenge of Timely, Responsive and Rigorous Ethics Review of Disaster Research: Views of Research Ethics Committee Members.

Matthew Hunt, Catherine M Tansey, James Anderson, Renaud F Boulanger et al. • PLoS ONE (2016)

Research conducted following natural disasters such as earthquakes, floods or hurricanes is crucial for improving relief interventions. Such research, however, poses ethical, methodological and logistical challenges for researchers. Oversig...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0157142

Robotic Arthroplasty Clinical and cost Effectiveness Randomised controlled trial (RACER-knee): a study protocol

Martin Underwood, Charles E Hutchinson, Helen Parsons, James Mason et al. • BMJ Open (2023)

Introduction Robotic-assisted knee replacement systems have been introduced to healthcare services worldwide in an effort to improve clinical outcomes for people, although high-quality evidence that they are clinically, or cost-effective re...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2022-068255

Clinical features of the course of Hirschsprung’s disease in newborns and infants with consideration of the extent of colonic aganglionosis

V.P. Prytula, O.O. Kurtash, V.F. Rybalchenko, S.F. Hussaini • Український журнал Перинатологія і педіатрія (2024)

The clinical course of Hirschsprung’s disease (HD) in newborns and infants depends on the extent of сolonic aganglionosis, the age of patient, the presence of associated malformations and complications. The aim - to study the peculiariti...

DOAJ Open Access (DOAJ) DOI: 10.15574/PP.2024.97.55

Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF): protocol of a multicentre interventional randomised controlled clinical trial—investigating effects of a 12-week yoga intervention for adults with cystic fibrosis

Adam P Wagner, Nicholas J Simmonds, Susan C Charman, P Scarborough et al. • BMJ Open Respiratory Research (2026)

Introduction Yoga is an emerging exercise choice for people with cystic fibrosis (CF), but evidence of its effect in this population is scarce, with a recent systematic review advocating for further research. Yoga Outcomes Get Assessed in C...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjresp-2025-003405

Evaluation of clinical quality improvement interventions: feasibility of an integrated approach

Sandeep Reddy, Kevin Mc Namara, Mary Malakellis, Tim Denton et al. • Pilot and Feasibility Studies (2019)

Abstract Background Cardiovascular diseases (CVD) are the largest cause of death and disability in Australia. Australian national guidelines for the primary prevention of CVD recommend that all adults without CVD and aged 45 years or more a...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40814-018-0386-1

VirtualToxLab™ - In silico prediction of the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. Two years and 2,000 compounds of experience: a progress report

Angelo Vedani, Martin Smiesko, Morena Spreafico, Ourania Peristera et al. • ALTEX: Alternatives to Animal Experimentation (2009)

The VirtualToxLab™ is an in silico tool for predicting the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. It is based on a fully automated protocol and calculates the binding affinity of any molecule of int...

DOAJ Open Access (DOAJ) DOI: 10.14573/altex.2009.3.167

Effect of falls prevention interventions on falls and the risk factors for falls among cancer survivors: protocol for a systematic review

Lynette Mackenzie, Amanda M. Clifford, Eleanor Fallon, Joanna M. Allardyce • BMJ Open (2026)

Introduction Falls are a significant health concern and associated with cancer survivorship. Falls can result in negative psychosocial consequences for cancer survivors and economic sequelae for healthcare delivery. There are cancer-specifi...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2025-110212

An Improved Blockchain-Based Lightweight Vehicle-to-Infrastructure Handover Authentication Protocol for Vehicular Ad Hoc Networks

Shengbao Wang, Yixiao Wu, Kang Wen, Xin Zhou et al. • Mathematics (2025)

We conduct a cryptanalysis of the Vehicle-to-Infrastructure (V2I) handover authentication protocol newly developed by Son et al., which incorporates blockchain technology for authentication purposes. Although this approach is notably effici...

DOAJ Open Access (DOAJ) DOI: 10.3390/math13071118

Wellbeing intervention for chronic kidney disease (WICKD): a randomised controlled trial study protocol

Kylie M. Dingwall, Tricia Nagel, Jaquelyne T. Hughes, David J. Kavanagh et al. • BMC Psychology (2019)

Abstract Background Incidence of end stage kidney disease (ESKD) for Indigenous Australians is especially high in remote and very remote areas of Australia (18 and 20 times the rate of comparable non-Indigenous people). Relocating away from...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40359-018-0264-x

Effectiveness of a tele-rehabilitation intervention to improve performance and reduce morbidity for people post hip fracture - study protocol for a randomized controlled trial

Yafit Gilboa, Talia Maeir, Sharon Karni, Michal E. Eisenberg et al. • BMC Geriatrics (2019)

Abstract Background Most surviving hip-fracture patients experience reduced mobility and lose some of their functional ability, which increases the risk of complications and rehospitalization. Post-discharge transitional programs to reduce ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-019-1141-z

Neurological Manifestations of SARS-CoV-2 Infection: Protocol for a Sub-analysis of the COVID-19 Critical Care Consortium Observational Study

Denise Battaglini, Denise Battaglini, Lavienraj Premraj, Lavienraj Premraj et al. • Frontiers in Medicine (2022)

IntroductionNeurological manifestations and complications in coronavirus disease-2019 (COVID-19) patients are frequent. Prior studies suggested a possible association between neurological complications and fatal outcome, as well as the exis...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.930217

Psychological STress, Anxiety, and Depression After miscarriage in comparison to successful pregnancy and abortion: design and protocol for the observational cohort study STRADA

Maarit Mentula, Oskari Heikinheimo, Katri Räikkönen, Heini Sorasto et al. • BMJ Open (2026)

Introduction Miscarriage occurs in 15%–20% of clinically recognised pregnancies. It may cause acute or prolonged psychological distress such as anxiety, depression and post-traumatic stress disorder (PTSD). Data on symptom severity and dura...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2026-127865