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HEALTH TECHNOLOGY ASSESSMENT IN SPAIN

Alı́cia Granados, Laura Sampietro-Colom, José Asua, José Conde et al. • International Journal of Technology Assessment in Health Care (2000)

The Spanish Constitution of 1978 established a healthcare system available to everyone and free at the point of service. The General Health Law of 1986 also established the framework for a National Health System (NHS). The Constitution and ...

OPENALEX DOI: https://doi.org/10.1017/s026646230010114x

Epidemiology and clinical study of phenylketonuria (PKU) patients in Khorasan Province; Norteast Iran

Negar Morovatdar, Shapour Badiee Aval, Seyed Mohammad Reza Hosseini Yazdi, Farzaneh Norouzi et al. • Iranian Journal of Neonatology (2015)

Epidemiology and clinical study of phenylketonuria (PKU) patients in Khorasan Province; Norteast Iran Background: Phenylketonuria is an autosomal recessive disease. Early diagnosis is a important public health intervention to prevent neurol...

DOAJ Open Access (DOAJ)

Coffee Silverskin Phytocompounds as a Novel Anti-Aging Functional Food: A Pharmacoinformatic Approach Combined with In Vitro Study

Clarin Hayes, Fahrul Nurkolis, Dewa Ayu Agus Sri Laksemi, Sanghyun Chung et al. • Molecules (2023)

Coffee became a beverage that was in demand in the world and consequently produced millions of tons of coffee byproducts namely coffee silverskin (CS). Unutilized CS will be waste and cause environmental pollution such as greenhouse gas emi...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules28207037

Berberine protects against hypoxia-induced intestinal injury through modulation of gut microbiota and bile acid metabolism

Hao Zhang, Hao Zhang, Hao Zhang, Penghui Ye et al. • Frontiers in Immunology (2026)

BackgroundHigh-altitude hypoxia disrupts intestinal homeostasis by impairing the epithelial barrier, triggering inflammation, and promoting microbial translocation. Berberine (BER), a natural isoquinoline alkaloid with antimicrobial and ant...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2026.1784245

Pathway analysis of the impact of family function and self-efficacy on depression and anxiety in patients undergoing in vitro fertilization-embryo transfer

Fangliang Zou, Yi Fang, Yanshan Lin, Zikai Feng et al. • BMC Psychology (2024)

Abstract Background Patients undergoing assisted reproductive technology (ART) experience significant psychological distress due to infertility, with depression and anxiety being the most common manifestations. This study investigates the i...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40359-024-02246-y

HEALTH TECHNOLOGY ASSESSMENT IN CANADA

Devidas Menon, Leigh-Ann Topfer • International Journal of Technology Assessment in Health Care (2000)

OBJECTIVES: Since 1988, four government-funded health technology assessment (HTA) agencies have been established in Canada. This paper is a descriptive review of reports issued by these organizations during the period from 1988 to 1998. MET...

OPENALEX DOI: https://doi.org/10.1017/s0266462300102168

Design and Optimization of Trastuzumab-Functionalized Nanolipid Carriers for Targeted Capecitabine Delivery: Anti-Cancer Effectiveness Evaluation in MCF-7 and SKBR3 Cells

Das S, Satapathy BS, Pattnaik G, Pattanaik S et al. • International Journal of Nanomedicine (2025)

Shubhashree Das,1 Bhabani Sankar Satapathy,2 Gurudutta Pattnaik,1 Sovan Pattanaik,3 Yahya Alhamhoom,4 Mohamed Rahamathulla,4 Mohammed Muqtader Ahmed,5 Ismail Pasha6 1Department of Pharmaceutics, School of Pharmacy and Life Sciences, Centuri...

DOAJ Open Access (DOAJ)

Teachers’ experiences with the Back2School intervention—a pilot study addressing problematic school absenteeism

Elisabeth Valmyr Bania, Toril Sørheim Nilsen, Mikael Thastum, Jo Magne Ingul et al. • Frontiers in Psychology (2025)

IntroductionSchool absenteeism represents a concern for students, educators, and parents alike. Teachers’ involvement is vital to students’ school life. Consequently, integrating schools and teachers effectively in absenteeism interventions...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyg.2025.1608184

Compounds of Marine Origin with Possible Applications as Healing Agents

Nektaria-Ioanna Karma, Fotini Mellou, Panagoula Pavlou, Angeliki Siamidi et al. • Marine Drugs (2024)

It is well established that marine organisms consist of a great variety of active compounds that appear exclusively in the marine environment while having the ability to be vastly reproduced, irrespective of the existing conditions. As a re...

DOAJ Open Access (DOAJ) DOI: 10.3390/md23010005

Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment

Chieh-Liang Huang, Chieh-Liang Huang, Yao-Chang Chiang, Wei-Chun Chang et al. • Frontiers in Endocrinology (2021)

Methadone maintenance treatment (MMT) remains the cornerstone for the management of opiate abuse. However, MMT can be associated with complex factors, including complications during the tolerance phase, the inability of some patients to mai...

DOAJ Open Access (DOAJ) DOI: 10.3389/fendo.2021.638884

Effectiveness of Back care education Programme among school children: a systematic review of randomized controlled trials

Canice Chukwudi Anyachukwu, Confidence Chinemerem Amarah, Blessing Chiagozikam Atueyi, Ifeanyi Anthony et al. • BMC Pediatrics (2024)

Abstract Study design Systematic review of Randomised controlled trials. Objectives With the increasing incidence of back pain among children and its untold implications to their future, back education tailored in an effective way would be ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12887-024-04563-y

A Prospective, Randomized Trial Comparing Hydromorphone and Nalbuphine for Postcesarean Patient-Controlled Analgesia and Developing a Risk Prediction Model for Inadequate Analgesia

Zhang K, Sun J, Zhang C, Jiao B et al. • Drug Design, Development and Therapy (2025)

Kaiwen Zhang,1,* Jiaoli Sun,1,* Caixia Zhang,2 Bo Jiao,1 Wencui Zhang,1 Shangchen Yu,1 Xueqin Cao,1 Zhiqiang Zhou,1 Guanglei Zhang,1 Xianwei Zhang1 1Department of Anesthesiology and Pain Medicine,Hubei Key Laboratory of Geri...

DOAJ Open Access (DOAJ)

Comparison of the effectiveness of an oral combination of thiamine, pyridoxine, and cyanocobalamin with parenteral cyanocobalamin in adolescents with nutritional vitamin B12 deficiency

Ömer Güneş, Mehmet Ağıllı, Fatih Üçkardeş, Yüksel Hakan Aydoğmuş et al. • Gülhane Tıp Dergisi (2024)

Aims: Nutritional vitamin B12 deficiency remains a significant public health issue. This study aimed to compare the efficacy of an oral combination of thiamine, pyridoxine, cyanocobalamin, and parenteral cyanocobalamin treatment among adole...

DOAJ Open Access (DOAJ) DOI: 10.4274/gulhane.galenos.2024.47135

Deep learning prediction of pathological complete response in breast cancer using Mamba architecture

Wenchuan Zhang, Shuwan Zhang, Fengling Li, Yuanyuan Zhao et al. • npj Digital Medicine (2026)

Abstract Deep learning is capable of efficiently predicting the therapeutic efficacy of neoadjuvant chemotherapy (NAC) in breast cancer. However, current methods predominantly rely on convolutional neural networks or transformer architectur...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41746-026-02849-2

From Connectivity to Controllability: Unraveling the Brain Biomarkers of Major Depressive Disorder

Chunyu Pan, Ying Ma, Lifei Wang, Yan Zhang et al. • Brain Sciences (2024)

Major Depressive Disorder (MDD) is a significant neurological condition associated with aberrations in brain functional networks. Traditional studies have predominantly analyzed these from a network topology perspective. However, given the ...

DOAJ Open Access (DOAJ) DOI: 10.3390/brainsci14050509

Denosumab and Bisphosphonate Treatment of Osteoporosis in Renal Transplant Recipients

Serdar Şahin, Nurhan Seyahi, Sinan Trabulus, Hande Mefkure Özkaya et al. • Cerrahpaşa Medical Journal (2021)

Objective: Kidney transplant recipients are at risk of losing bone mineral density. Osteoporosis and fractures cause serious complications in renal transplant recipients. We aimed to evaluate the efficacy and safety of bisphosphonate and de...

DOAJ Open Access (DOAJ) DOI: 10.5152/cjm.2021.21039