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The Downregulation of eIF3a Contributes to Vemurafenib Resistance in Melanoma by Activating ERK via PPP2R1B

Shi-Long Jiang, Shi-Long Jiang, Zhi-Bin Wang, Zhi-Bin Wang et al. • Frontiers in Pharmacology (2021)

Vemurafenib, a BRAF V600E inhibitor, provides therapeutic benefits for patients with melanoma, but the frequent emergence of drug resistance remains a challenge. An understanding of the mechanisms underlying vemurafenib resistance may gener...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2021.720619

Molecular Informatics, Chemometrics, and Sensory Omics for Constructing an Umami Peptide Cluster Library Across the Entire Lager Beer Brewing Process

Yashuai Wu, Ruiyang Yin, Wenjing Tian, Wanqiu Zhao et al. • Foods (2026)

Umami taste in lager beer not only determined body fullness and the backbone of aftertaste, but also affected the controllability and interpretability of flavor expression across the entire brewing process. Based on stage-wise sampling, pep...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods15040641

ASSESSMENT OF THE LEARNING CURVE IN HEALTH TECHNOLOGIES

Craig Robert Ramsay, Adrian Grant, Sheila A. Wallace, Paul H. Garthwaite et al. • International Journal of Technology Assessment in Health Care (2000)

OBJECTIVE: We reviewed and appraised the methods by which the issue of the learning curve has been addressed during health technology assessment in the past. METHOD: We performed a systematic review of papers in clinical databases (BIOSIS, ...

OPENALEX DOI: https://doi.org/10.1017/s0266462300103149

HEALTH TECHNOLOGIES

Maria Carolina Salustino dos Santos, Ana Emília Araújo de Oliveira, Raquel Carvalho Lima, Iracema Vitória Gomes Lins Paz et al. • Health and Society (2022)

The use of health technologies provides better health management, anchored in equity, communication and governance in health. Technologies are conceptualized as a tool, which helps from planning to the execution of activities, and can be ap...

OPENALEX cc-by DOI: https://doi.org/10.51249/hs.v2i02.1011

Statistical assessment of the learning curves of health technologies

Craig Robert Ramsay, Adrian Grant, Sheila A. Wallace, Paul H. Garthwaite et al. • Health Technology Assessment (2001)

OBJECTIVES: (1) To describe systematically studies that directly assessed the learning curve effect of health technologies. (2) Systematically to identify 'novel' statistical techniques applied to learning curve data in other fields, such a...

OPENALEX cc-by DOI: https://doi.org/10.3310/hta5120

Purification, Characterization and Bactericidal Action of Lysozyme, Isolated from <i>Bacillus subtillis</i> BSN314: A Disintegrating Effect of Lysozyme on Gram-Positive and Gram-Negative Bacteria

Muhammad Naveed, Yadong Wang, Xian Yin, Malik Wajid Hussain Chan et al. • Molecules (2023)

In the present study, lysozyme was purified by the following multi-step methodology: salt (ammonium sulfate) precipitation, dialysis, and ultrafiltration. The lysozyme potential was measured by enzymatic activity after each purification ste...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules28031058

Full-thickness skin graft versus split-thickness skin graft for radial forearm free flap donor site closure: protocol for a systematic review and meta-analysis

Jasper J.E. Moors, Zhibin Xu, Kunpeng Xie, Ashkan Rashad et al. • Systematic Reviews (2024)

Abstract Background The radial forearm free flap (RFFF) serves as a workhorse for a variety of reconstructions. Although there are a variety of surgical techniques for donor site closure after RFFF raising, the most common techniques are cl...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13643-024-02471-x

Population dataset for 23 Y-STR in the Merkit clan form Kazakh population

Bekzhan Faizov, Alizhan Bukayev, Zhaxylyk Sabitov, Maxat Zhabagin • Data in Brief (2024)

This study presents a comprehensive analysis of 23 Y-STR data for the Merkit clan, a subgroup within the Kerey tribe of the Kazakh people. A total of 64 complete haplotypes were generated using the PowerPlex Y23 System. The data obtained us...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dib.2024.110160

Medical, dental, and nursing students’ attitudes and knowledge towards artificial intelligence: a systematic review and meta-analysis

Hamidreza Amiri, Samira Peiravi, Seyedeh sara rezazadeh shojaee, Motahareh Rouhparvarzamin et al. • BMC Medical Education (2024)

Abstract Background Nowadays, Artificial intelligence (AI) is one of the most popular topics that can be integrated into healthcare activities. Currently, AI is used in specialized fields such as radiology, pathology, and ophthalmology. Des...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12909-024-05406-1

SAP BusinessObjects in Medical Informatics

Iwan Sofjan, Irim Salik, Peter Panzica • Cureus (2023)

Electronic health record (EHR) generates a large amount of data filled with opportunities to enhance documentation compliance, quality improvement, and other metrics. Various software tools exist, but many clinicians are unaware of them. Ou...

OPENALEX cc-by DOI: https://doi.org/10.7759/cureus.40208 PMC: 10331897

Medical and Health-Related Misinformation on Social Media: Bibliometric Study of the Scientific Literature

Andy Wai Kan Yeung, Anela Tosevska, Elisabeth Klager, Fabian Eibensteiner et al. • Journal of Medical Internet Research (2022)

BackgroundSocial media has been extensively used for the communication of health-related information and consecutively for the potential spread of medical misinformation. Conventional systematic reviews have been published on this topic to ...

DOAJ Open Access (DOAJ) DOI: 10.2196/28152

Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study

Janey Sewell, Carole Kelly, Adamma Aghaizu, Hannah Kitt et al. • JMIR Research Protocols (2025)

BackgroundDue to advances in treatment, HIV is now a chronic condition with near-normal life expectancy. However, people with HIV continue to have a higher burden of mental and physical health conditions and are impacted by wider socioecono...

DOAJ Open Access (DOAJ) DOI: 10.2196/58531

Fast Healthcare Interoperability Resources (FHIR) for Interoperability in Health Research: Systematic Review

Carina Nina Vorisek, Moritz Lehne, Sophie Anne Ines Klopfenstein, Paula Josephine Mayer et al. • JMIR Medical Informatics (2022)

BackgroundThe standard Fast Healthcare Interoperability Resources (FHIR) is widely used in health information technology. However, its use as a standard for health research is still less prevalent. To use existing data sources more efficien...

DOAJ Open Access (DOAJ) DOI: 10.2196/35724

Mapping Intellectual Structure of Health Literacy Area Based on Co-Word Analysis in Web of Science Database during the Years 1993-2017

Fatemeh Baji, Fereydoun Azadeh, Parastoo Parsaei-Mohammadi, Shoukat Parmah • مدیریت اطلاعات سلامت (2018)

Introduction: Creating an image of the conceptual structure of health literacy area, as well as the study of interdisciplinary and the relationship between its domains seems necessary. The present study examined the intellectual structure o...

DOAJ Open Access (DOAJ) DOI: 10.22122/him.v15i3.3577

Medical informatics across Europe: Analysis of medical informatics scientific output in 33 European countries

Ozren Polašek, Josipa Kern • Informatics for Health and Social Care (2011)

OBJECTIVES: To investigate the medical informatics scientific output in 33 European countries. METHODS: Medical Subject Heading term "medical informatics" was used to identify all relevant articles published in 1998-2007 and indexed in the ...

OPENALEX DOI: https://doi.org/10.3109/17538157.2011.590256

Identifying Applied Aspects, Medical Fields, and Technological Trends in Developing Future Entrepreneurial Opportunities in Telemedicine

Ali Mobini-Dehkordi, Jahangir Yadolai-Farsi, Abolghasem Arabiun, Mustafa Keshavarz-Turk • مدیریت اطلاعات سلامت (2021)

Introduction: Parallel with the growth of technologies, which affect the telemedicine, timely identification of telemedicine entrepreneurial opportunities seems to be necessary for the product development. This study aimed to identify appli...

DOAJ Open Access (DOAJ) DOI: 10.22122/him.v17i6.4230

Effectiveness and Related Factors of Narrative Messages in Correcting Health-Related Misinformation: Protocol for a Systematic Review

Tsuyoshi Okuhara, Hiroko Okada, Rie Yokota • JMIR Research Protocols (2025)

BackgroundThe internet and social media have become essential sources of health information for patients and citizens; however, they often disseminate misinformation that lacks scientific evidence. Health-related misinformation can undermin...

DOAJ Open Access (DOAJ) DOI: 10.2196/69414