Academic Articles & Research Papers

Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey

Abstract Background Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient’s health status, including physical, emotional, mental and social well-being. In this study, we aimed t...

Data on genotypic distribution and linkage disequilibrium of several ANRIL polymorphisms in hemodialysis patients

A long non-coding RNA called ANRIL located on chromosome 9p21.3 has been identified as a novel genetic factor associated with cardiovascular disease. Investigation of several single nucleotide polymorphisms (SNPs) of Noncoding Antisense RNA...

Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

¿Cómo es la cirugía cardiaca neonatal en un centro terciario en México?

Resumen: Introducción y objetivos: México posee instituciones públicas y privadas para atender a 120 millones de habitantes. Nuestro hospital pediátrico es una institución pública del Instituto Mexicano del Seguro Social. Presentamos nuest...

Preparedness of health facilities in managing hypertension & diabetes mellitus in Kilimanjaro, Tanzania: a cross sectional study

Abstract Background Hypertension and Diabetes mellitus are risk factors for cardiovascular diseases that cause 17 million deaths globally. Many of these deaths could have been prevented if hypertensive and diabetic patients had their blood ...

Cardiovascular risk management system: prerequisites for developing, organization principles, target groups

Cardiovascular morbidity and mortality are associated with high demographic and economic  losses.  Their decrease is one  of the  main lines of development  and improvement of the world health systems. An analysis of the current situation i...

HFA of the ESC Position paper on the management of LVAD supported patients for the non LVAD specialist healthcare provider Part 1: Introduction and at the non‐hospital settings in the community

Abstract The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of the LVAD‐supported patients on the device a...

Policy Recommendations for Information Prescribing to Heart Failure Patients to Reduce Readmissions, Mortality, and Costs

Introduction: Heart failure is a leading cause of hospitalization and mortality, with frequent readmissions mainly due to poor self-care knowledge and low medication adherence. These readmissions increase healthcare costs and reduce patient...

Persistent Endothelial Dysfunction in Post-Acute COVID-19 Syndrome: A Case-Control Study

Background: Endothelial dysfunction has a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its disabling complications. We designed a case-control study to assess the alterations of endothelium-dependent flow-mediated...

Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC is usually detected at the advanced stages of the disease, making it highly lethal. miRNAs are single-stranded, small non-coding RNAs with an approxim...

Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

The Mitochondria is a critical sub-cellular organelle that plays an integral part in a normal cellular process. Besides ATP production, the mitochondria participate in various key cellular processes such as cell signaling, epigenetic regula...

Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of IK(M) or IK(DR) and in the Stimulation of IMEP

Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane ...

YAP1 reactivation in cardiomyocytes following ECM remodelling contributes to the development of contractile force and sarcomere maturation

Abstract Cardiac diseases are fueled by extracellular matrix (ECM) remodelling. Together with the altered ECM chemical composition, the mechanical turmoil associated with ECM maladaptive remodelling in the pathological heart drives the shut...

Advances in Medical Biotechnology

Medical Biotechnology in Society

This chapter provides relevant scientific and historical information relating to genetic testing and human embryonic stem (hES) cell therapies and describes some of the societal issues surrounding them. The risks of invasive diagnostic test...

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

Wearable ECG Device and Machine Learning for Heart Monitoring

With cardiovascular diseases (CVD) remaining a leading cause of mortality, wearable devices for monitoring cardiac activity have gained significant, renewed interest among the medical community. This paper introduces an innovative ECG monit...

Use of Stem Cells in the Treatment of Myocardial Infarction

Considerable research has been done in the past few decades to treat ischemic heart disease (stroke). Although drug therapies can improve heart disease and reduce mortality in heart failure, none is able to regenerate damaged heart tissue. ...

A single-cell RNA sequencing dataset of cardiac aging in African Turquoise Killifish

Abstract Aging is a major contributor to functional decline of the heart and various cardiovascular diseases. Alterations across different cardiac cell types must be tightly orchestrated during the normative aging process that has begun to ...

Lifestyle interventions to maternal weight loss after birth: a systematic review

Abstract Background Over the past decades, there has been an increase in overweight and obesity in women of childbearing age, as well as the general population. Overweight and obesity are related to a later, increased risk of type 2 diabete...