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A coordinated and enhanced brain network supports the persistence of long-term cocaine memory

Xuan Chen, Zihang Li, Yong Han, Liping Yang et al. • Translational Psychiatry (2025)

Abstract The persistence of drug memories accounts for the high risk of drug relapse, which is a major challenge in the treatment of substance use disorders. However, the neurobiological underpinnings, especially the dynamic changes of brai...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41398-025-03667-y

Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

Daiki X. Sato, Yukiko U. Inoue, Nahoko Kuga, Satoko Hattori et al. • iScience (2022)

Summary: The human vesicular monoamine transporter 1 (VMAT1) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles. These substitutions are absent in all known mammals, suggesting their contributio...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.isci.2022.104800

An open dataset and machine learning algorithms for Niacin Skin-Flushing Response based screening of psychiatric disorders

Xuening Lyu, Rimsa Goperma, Dandan Wang, Chunling Wan et al. • BMC Psychiatry (2025)

Abstract Background Niacin Skin-Flushing Response (NSR) has emerged as a promising objective biomarker for the precise diagnosis of mental disorders. However, its diagnostic potential has been constrained by the limitations of traditional s...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12888-025-07196-2

Key factors and serial mediation analysis of anxiety and depression among university students: a cross-sectional study

Tan Jiang, Shijia Zhang, Shijia Zhang, Deyou Jiang • Frontiers in Psychiatry (2026)

BackgroundAnxiety and depressive symptoms are prevalent among university students; however, their risk factors are unlikely to operate in isolation. Instead, they may be organized in a multilevel structure that progressively approaches emot...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyt.2026.1809332

Prediction of emergency department revisits among child and youth mental health outpatients using deep learning techniques

Simran Saggu, Hirad Daneshvar, Reza Samavi, Paulo Pires et al. • BMC Medical Informatics and Decision Making (2024)

Abstract Background The proportion of Canadian youth seeking mental health support from an emergency department (ED) has risen in recent years. As EDs typically address urgent mental health crises, revisiting an ED may represent unmet menta...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12911-024-02450-1