Academic Articles & Research Papers

Development of Anticancer Peptides Using Artificial Intelligence and Combinational Therapy for Cancer Therapeutics

Cancer is a group of diseases causing abnormal cell growth, altering the genome, and invading or spreading to other parts of the body. Among therapeutic peptide drugs, anticancer peptides (ACPs) have been considered to target and kill cance...

Deep learning-based recognition and segmentation of intracranial aneurysms under small sample size

The manual identification and segmentation of intracranial aneurysms (IAs) involved in the 3D reconstruction procedure are labor-intensive and prone to human errors. To meet the demands for routine clinical management and large cohort studi...

Towards deep learning with segregated dendrites

Deep learning has led to significant advances in artificial intelligence, in part, by adopting strategies motivated by neurophysiology. However, it is unclear whether deep learning could occur in the real brain. Here, we show that a deep le...

Machine Learning and Data Mining Methods in Diabetes Research

The remarkable advances in biotechnology and health sciences have led to a significant production of data, such as high throughput genetic data and clinical information, generated from large Electronic Health Records (EHRs). To this end, ap...

A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients

Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed th...

Contribution of model organism phenotypes to the computational identification of human disease genes

Computing phenotypic similarity helps identify new disease genes and diagnose rare diseases. Genotype–phenotype data from orthologous genes in model organisms can compensate for lack of human data and increase genome coverage. In the past d...

Dissecting the dissection laboratory: Elements for designing a human anatomy laboratory: The Human Anatomy and Physiology Society (HAPS)-Anatomical Donor Stewardship (ADS) Committee, Lab Resources Subcommittee.

Editorial: Modern machine learning approaches for quantitative inference of gene regulation from genomic and epigenomic features

Fatigue Monitoring Through Wearables: A State-of-the-Art Review

The objective measurement of fatigue is of critical relevance in areas such as occupational health and safety as fatigue impairs cognitive and motor performance, thus reducing productivity and increasing the risk of injury. Wearable systems...

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation

Abstract Cerebral blood flow is essential for brain function and is governed by cerebral perfusion pressure and physiological mechanisms collectively referred to as cerebral vascular regulation (CVR). Direct measurement of cerebral blood fl...

Midbrain endocannabinoids actuate dopamine-based action selection

Summary: Quickly adapting behavior to changing environments is key for survival. Brain dopamine signals reinforce actions that procure rewards and avoid adverse outcomes. However, the molecular mechanisms within the circuits that actuate th...

Machine learning-derived prediction of in-hospital mortality in patients with severe acute respiratory infection: analysis of claims data from the German-wide Helios hospital network

Abstract Background Severe acute respiratory infections (SARI) are the most common infectious causes of death. Previous work regarding mortality prediction models for SARI using machine learning (ML) algorithms that can be useful for both i...

Artificial intelligence

In this paper, we will explore the magic of giving the power of thinking to man--made machines, i.e. Artificial Intelligence which is involved in many fields of electronics and computers. In 1956, John McCarthy who coined the term of Artifi...

Precision Microalgae: A New Conceptual Framework for Bioengineering Applications

Microalgae are promising platforms for biomass production, carbon capture, biofuels, and high-value bioproducts. However, despite significant advances in cultivation technologies, reactor engineering, and metabolic engineering, industrial i...

Examination of medical students’ opinions on multimedia learning materials according to social cues: focusing on sound principles

Purpose Although interest in various forms of learning media is increasing due to the coronavirus disease 2019 (COVID-19) pandemic there is relatively little research on influencing student motivation by intervening in cognitive processing....

Targeting pepsin provides superior protection to acid suppression in reflux-associated airway inflammation and lung dysfunction.