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Elevated Eosinophils as a Feature of Inflammation Associated With Hypertension in Virally Suppressed People Living With HIV

Sepiso K. Masenga, Fernando Elijovich, Benson M. Hamooya, Selestine Nzala et al. • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (2020)

Background People living with HIV (PLWH) are at increased risk of cardiovascular disease, including hypertension, which persists despite effective plasma viral suppression on antiretroviral therapy. HIV infection is characterized by long‐te...

DOAJ Open Access (DOAJ) DOI: 10.1161/JAHA.118.011450

Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α

Toledo JO, Moraes CF, Souza VC, Tonet-Furioso AC et al. • Clinical Interventions in Aging (2015)

Juliana O Toledo,1 Clayton F Moraes,2,3 Vinícius C Souza,2 Audrey C Tonet-Furioso,2 Luís CC Afonso,4 Cláudio Córdova,3 Otávio T Nóbrega1,2 1Graduate Program in Health Sciences, 2Graduate Program in...

DOAJ Open Access (DOAJ)

Therapeutic potential of hyaluronic acid hydrogel combined with bone marrow stem cells-conditioned medium on arthritic rats’ TMJs

Mai M. Assi, Mohammed E. Grawish, Heba Mahmoud Elsabaa, Mohamad E. Helal et al. • Scientific Reports (2024)

Abstract Conditioned media (CM) is derived from mesenchymal stem cells (MSC) culture and contains biologically active components. CM is easy to handle and reduces inflammation while repairing injured joints. Combination therapy of the CM wi...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-024-77325-6

Association of inflammation and cognition in the elderly: A systematic review and meta-analysis

Sofia Leonardo, Felipe Fregni • Frontiers in Aging Neuroscience (2023)

BackgroundThe development of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) may be associated with an inflammatory process. Inflammatory cytokines may be a surrogate for systemic inflammation leading to worsening neurological ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnagi.2023.1069439

<i>Carthamus tinctorius</i> Suppresses LPS-Induced Anti-Inflammatory Responses by Inhibiting the MAPKs/NF-κB Signaling Pathway in HaCaT Cells

So-Yeon Kim, Minji Hong, Ponnuvel Deepa, Kandhasamy Sowndhararajan et al. • Scientia Pharmaceutica (2023)

This study aimed to elucidate the anti-inflammatory activity of C. tinctorius leaves by measuring inflammatory parameters such as nitric oxide (NO) production and mRNA expression of iNOS, interleukin-6 (IL-6), and IL-1β in lipopolysaccharid...

DOAJ Open Access (DOAJ) DOI: 10.3390/scipharm91010014

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods (2025)

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14234030

Nucleotide-binding oligomerization domain protein-1 is expressed and involved in the inflammatory response in human sebocytes

Natsuko Kitajima, Takahisa Nakajo, Takeshi Katayoshi, Kentaro Tsuji-Naito • Biochemistry and Biophysics Reports (2023)

Sebocytes express Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), which participate in the innate immune response of the skin. Although the roles of TLRs and NLR family pyrin domain-cont...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.bbrep.2023.101561

Dysregulation of Angiogenesis and Inflammatory Genes in Endometrial Mesenchymal Stem Cells and Their Contribution to Endometriosis

Shermineh Heydari, Ladan Kashani, Mehrdad Noruzinia • Iranian Journal of Allergy, Asthma and Immunology (2021)

Endometriosis is a common, chronic, inflammatory disorder in women, characterized by the presence of endometrial tissue outside the uterus cavity. The disease affects ~10% of women during their reproductive age. There is some debates on the...

DOAJ Open Access (DOAJ)

miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4

Jinyu Liu, Xiaowei Yuan, Wei Chen, Dongqin Shen • Clinical and Applied Thrombosis/Hemostasis (2026)

Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis dia...

DOAJ Open Access (DOAJ) DOI: 10.1177/10760296261468449

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review.

John Danesh, Stephen Kaptoge, Andrea G Mann, Nadeem Sarwar et al. • PLoS Medicine (2008)

BackgroundThe relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations. We evaluated asso...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pmed.0050078

Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm

Hee-Sung Chae, Sun Young Kim, Pisey Pel, Jungmoo Huh et al. • Molecules (2020)

Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic obstructive pulmonary diseases. To relieve these symptoms and diseases, various ingredients are being used desp...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules25133064

Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages

Hai-Ning Wee, Soek-Ying Neo, Deepika Singh, Hui-Chuing Yew et al. • BMC Complementary Medicine and Therapies (2020)

Abstract Background Dysregulation of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) form the basis of immune-mediated inflammatory diseases. Vitex trifolia L. is a medicinal plant growing in co...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12906-020-02884-w

Protocol to measure human IL-6 secretion from CAR T cell-primed macrophage and monocyte lineage cells in vitro and in vivo using humanized mice

Thao Nguyen, Toshiaki Yoshikawa, Yusuke Ito, Hitomi Kasuya et al. • STAR Protocols (2024)

Summary: Chimeric antigen receptor (CAR) T cell therapy often causes serious toxicities, such as cytokine release syndrome (CRS), mainly due to interleukin-6 (IL-6) secreted by monocyte lineage cells. Here, we describe a protocol to generat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.xpro.2024.103423

NLRP3 Inflammasome-Mediated Pyroptosis Pathway Contributes to the Pathogenesis of Candida albicans Keratitis

Huifang Lian, Huifang Lian, Huifang Lian, Huifang Lian et al. • Frontiers in Medicine (2022)

PurposeFungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.845129

Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold

Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri et al. • Journal of Nanobiotechnology (2021)

Abstract Background Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature. We prepared bi- o...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-021-00871-y

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation

Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych et al. • Advanced NanoBiomed Research (2022)

Neuroinflammation is one of the hallmarks contributing to Parkinson's disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular α‐synuclein (aSYN) binding to the cluster of differen...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202100120

Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease

Hamid Reza Rahimi, Mahmoud Reza Jaafari, Amir Hooshang Mohammadpour, Khalil Abnous et al. • Asia Pacific Journal of Medical Toxicology (2015)

Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal me...

DOAJ Open Access (DOAJ) DOI: 10.22038/apjmt.2015.3983

Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model

Zhen Li, Yannik Gehlen, Yannik Gehlen, Fabian Heizmann et al. • Frontiers in Bioengineering and Biotechnology (2020)

Discogenic low back pain (LBP) is a main cause of disability and inflammation is presumed to be a major driver of symptomatic intervertebral disc degeneration (IDD). Anti-inflammatory agents are currently under investigation as they demonst...

DOAJ Open Access (DOAJ) DOI: 10.3389/fbioe.2020.00583

Flavanol-Rich Cocoa Supplementation Inhibits Mitochondrial Biogenesis Triggered by Exercise

Jose Angel García-Merino, Beatriz de Lucas, Karen Herrera-Rocha, Diego Moreno-Pérez et al. • Antioxidants (2022)

The potential role of cocoa supplementation in an exercise context remains unclear. We describe the effects of flavanol-rich cocoa supplementation during training on exercise performance and mitochondrial biogenesis. Forty-two male enduranc...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox11081522