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Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man.

Evangelia Charmandari, George P Chrousos, George I Lambrou, Aikaterini Pavlaki et al. • PLoS ONE (2011)

Context and objectiveCirculating cortisol fluctuates diurnally under the control of the "master" circadian CLOCK, while the peripheral "slave" counterpart of the latter regulates the transcriptional activity of the glucocorticoid receptor (...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0025612

Elevated Eosinophils as a Feature of Inflammation Associated With Hypertension in Virally Suppressed People Living With HIV

Sepiso K. Masenga, Fernando Elijovich, Benson M. Hamooya, Selestine Nzala et al. • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (2020)

Background People living with HIV (PLWH) are at increased risk of cardiovascular disease, including hypertension, which persists despite effective plasma viral suppression on antiretroviral therapy. HIV infection is characterized by long‐te...

DOAJ Open Access (DOAJ) DOI: 10.1161/JAHA.118.011450

Copper exposure association with prevalence of non-alcoholic fatty liver disease and insulin resistance among US adults (NHANES 2011–2014)

Chen Chen, Qi Zhou, Ruiyue Yang, Zhu Wu et al. • Ecotoxicology and Environmental Safety (2021)

Background: Excessive copper (Cu) has risky effect on insulin resistance (IR), oxidative stress and inflammation. Instead, some studies reported serum Cu to be protective for non-alcoholic fatty liver disease (NAFLD). The aim of this study ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ecoenv.2021.112295

A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil

Maria Luiza Lima-Silva, Karen Cecília Lima Torres, Juliana Vaz de Melo Mambrini, Nathalia Coimbra Brot et al. • Experimental Gerontology (2024)

Immunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as “Inflammaging.” Inflammaging can be associated with many dis...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2024.112433

Long Noncoding RNAs in Neurodegenerative Diseases: Pathogenesis and Potential Implications as Clinical Biomarkers

Meng Zhang, Ping He, Zhigang Bian • Frontiers in Molecular Neuroscience (2021)

Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are progressive and ultimately fatal. NDD onset is influenced by several fa...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2021.685143

Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α

Toledo JO, Moraes CF, Souza VC, Tonet-Furioso AC et al. • Clinical Interventions in Aging (2015)

Juliana O Toledo,1 Clayton F Moraes,2,3 Vinícius C Souza,2 Audrey C Tonet-Furioso,2 Luís CC Afonso,4 Cláudio Córdova,3 Otávio T Nóbrega1,2 1Graduate Program in Health Sciences, 2Graduate Program in...

DOAJ Open Access (DOAJ)

Plant nutritional value of aquaculture water produced by feeding Nile tilapia (Oreochromis niloticus) alternative protein diets: A lettuce and basil case study

Jeffrey J. Jones, Christopher Shaw, Tsu‐Wei Chen, Christopher Martin Staß et al. • Plants, People, Planet (2024)

Societal Impact Statement Refining circular multitrophic food production methods, which integrate plant, fish, and insect outputs, is imperative for environmental sustainability. Our findings suggest that the right protein choices in fish f...

DOAJ Open Access (DOAJ) DOI: 10.1002/ppp3.10457

Impact of Myocardial Ischemia and Revascularization by Percutaneous Coronary Intervention on Circulating Level of Soluble ST2

Alkhateeb A, Mahmoud HEM, AK M, Hassan MH et al. • Vascular Health and Risk Management (2023)

Areej Alkhateeb,1 Hossam Eldin M Mahmoud,1 Mohammed AK,1 Mohammed H Hassan,2 Abdel Rahim Mahmoud Muddathir,3 Ahmed G Bakry1 1Cardiology Division of Internal Medicine Department, South Valley University Hospital, Faculty of Medicine, South V...

DOAJ Open Access (DOAJ)

Experimental Study on the Effect of the Angle of Attack on the Flow-Induced Vibration of a Harbor Seal’s Whisker

Yuhan Wei, Chunning Ji, Dekui Yuan, Liqun Song et al. • Fluids (2023)

A harbor seal’s whisker is able to sense the trailing vortices of marine organisms due to its unique three-dimensional wavy shape, which suppresses the vibrations caused by its own vortex-shedding, while exciting large-amplitude and synchro...

DOAJ Open Access (DOAJ) DOI: 10.3390/fluids8070206

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review.

John Danesh, Stephen Kaptoge, Andrea G Mann, Nadeem Sarwar et al. • PLoS Medicine (2008)

BackgroundThe relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations. We evaluated asso...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pmed.0050078

Circulating tumour cell enumeration, biomarker analyses, and kinetics in patients with colorectal cancer and other GI malignancies

Walla Malkawi, Areeb Lutfi, Maaz Khan Afghan, Lamisha Mashiyat Shah et al. • Frontiers in Oncology (2023)

ObjectiveMost of the work in terms of liquid biopsies in patients with solid tumors is focused on circulating tumor DNA (ctDNA). Our aim was to evaluate the feasibility of using circulating tumor cells (CTCs) in peripheral blood samples fro...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2023.1305181

Exercise Training and Circulating Small Extracellular Vesicles: Appraisal of Methodological Approaches and Current Knowledge

Ian A. J. Darragh, Lorraine O’Driscoll, Lorraine O’Driscoll, Lorraine O’Driscoll et al. • Frontiers in Physiology (2021)

In response to acute exercise, an array of metabolites, nucleic acids, and proteins are enriched in circulation. Collectively termed “exercise factors,” these molecules represent a topical area of research given their speculated contributio...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphys.2021.738333