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Showing 20 of 288 academic articles

Progressive suppression of regulated cell death defines terminal macrophage states in liver cirrhosis

Kepu Zheng, Leiyang Dai, Yanghui Wen, Haitao Jiang et al. • Annals of Medicine (2026)

Background Macrophages are central regulators of liver immunity and fibrosis; Recent single-cell studies have characterized macrophage heterogeneity in cirrhosis; however, how regulated cell death programs shape their functional transitions...

DOAJ Open Access (DOAJ) DOI: 10.1080/07853890.2026.2690717

A Comparative Analysis of the Chloroplast Genomes of Four Polygonum Medicinal Plants

Shuai Guo, Shuai Guo, Xuejiao Liao, Xuejiao Liao et al. • Frontiers in Genetics (2022)

Polygonum is a generalized genus of the Polygonaceae family that includes various herbaceous plants. In order to provide aid in understanding the evolutionary and phylogenetic relationship in Polygonum at the chloroplast (cp) genome-scale l...

DOAJ Open Access (DOAJ) DOI: 10.3389/fgene.2022.764534

Effectiveness of Ultrasound Imaging in Assessing the Palpation Skills of Rotating Physicians

Peizhen Huang, Bin Zheng, Shan Liu, Lin Xu et al. • Frontiers in Genetics (2022)

As an important means of physical examination, palpation is usually limited to the physical examination before surgery and used as an auxiliary method for disease diagnosis in the field of surgery. In practice, palpation is also used in eve...

DOAJ Open Access (DOAJ) DOI: 10.3389/fgene.2022.894716

The Alberta Congenital Anomalies Surveillance System: a 40-year review with prevalence and trends for selected congenital anomalies, 1997–2019

R. Brian Lowry, Tanya Bedard, Xin Grevers, Susan Crawford et al. • Health Promotion and Chronic Disease Prevention in Canada (2023)

IntroductionCurrent published long-term provincial or territorial congenital anomaly data are lacking for Canada. We report on prevalence (per 1000 total births) and trends in 1997–2019, in Alberta, Canada, for selected congenital anomalies...

DOAJ Open Access (DOAJ) DOI: 10.24095/hpcdp.43.1.04

How can we promote gender and sex equality in orthopaedics and traumatology surgery? Research avenues perspectives

Agathe Yvinou, Romain Alain • Journal of Orthopaedic Surgery and Research (2025)

Abstract Gender and sex disparities persist in orthopaedic and traumatology surgery, making it one of the least diverse medical specialties worldwide. Despite growing women representation in medical education, women continue to be significa...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13018-025-06170-8

Clinical Impact of Patient-Specific 3D Models in Neonatal Surgery: A Case-Based Review of Applications and Future Directions

Oscar Girón-Vallejo, Bernardo Garcia-Nuñez, Isidoro Narbona-Arias, Alexander Siles-Hinojosa et al. • Children (2025)

Three-dimensional (3D) modeling and printing technologies are increasingly used in pediatric surgery, offering improved anatomical visualization, surgical planning, and personalized approaches to complex conditions. Compared to standard ima...

DOAJ Open Access (DOAJ) DOI: 10.3390/children12091202

CAFs activated by YAP1 upregulate cancer matrix stiffness to mediate hepatocellular carcinoma progression

Wei Yan, Guo-hui Xiao, Li-juan Wang, Yan Zhou et al. • Journal of Translational Medicine (2025)

Abstract Background The stiffness of the matrix is closely related to the progression of hepatocellular carcinoma (HCC). Although direct targeting of stromal rigidity in HCC remains a clinical challenge, cancer-associated fibroblasts (CAFs)...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12967-025-06325-5

Patient-Reported Continued Benefits in Patients Treated with Pexidartinib for Tenosynovial Giant Cell Tumor Based on a Real-World Study in the United States

Margaret Wooddell PhD, MBA, Dong Dai PhD, Feng Lin PhD, Irene Pan MS et al. • Foot & Ankle Orthopaedics (2024)

Category: Other Introduction/Purpose: Tenosynovial giant cell tumors (TGCT) are neoplastic, inflammatory lesions that arise within the synovium and can be locally aggressive. Patients with TGCT frequently experience pain and joint swelling,...

DOAJ Open Access (DOAJ) DOI: 10.1177/2473011424S00422

Evaluation of Impedance and Reactance in the Intensive Treatment of Lymphoedema

Jose Maria Pereira De Godoy, Henrique Jose Pereira De Godoy, Maria De Fatima Guerreiro Godoy • Journal of Clinical and Diagnostic Research (2019)

Introduction: Lymphoedema is a progressive, chronic, clinical sign of an abnormal accumulation of macromolecules in the interstitial space that causes a buildup of fluids. Aim: To evaluate specific data of bioimpedance such as impedance and...

DOAJ Open Access (DOAJ) DOI: 10.7860/JCDR/2019/40158.12806

Fear of Falling After Total Knee Replacement: A Saudi Experience

Turki Aljuhani, Jayachandran Vetrayan, Mohammed A. Alfayez, Saleh A. Alshehri et al. • Clinics and Practice (2025)

Background: Fear of falling (FOF) is a significant concern among older adults, especially after total knee arthroplasty (TKA). FOF can limit daily activities, reduce quality of life, and hinder recovery. This study aimed to investigate the ...

DOAJ Open Access (DOAJ) DOI: 10.3390/clinpract15080146

The Architecture of an Automatic eHealth Platform With Mobile Client for Cerebrovascular Disease Detection

Wang, Xingce, Bie, Rongfang, Sun, Yunchuan, Wu, Zhongke et al. • JMIR mHealth and uHealth (2013)

BackgroundIn recent years, cerebrovascular disease has been the leading cause of death and adult disability in the world. This study describes an efficient approach to detect cerebrovascular disease. ObjectiveIn order to improve...

DOAJ Open Access (DOAJ) DOI: 10.2196/mhealth.2550

Do Ankle Sleeves And Lace-Up Braces Effect Neuromuscular Control And Athletic Performance?

Blake Bodendorfer, Gary Stover, Christopher Ryan James MD, Nicholas R. Arnold BS et al. • Orthopaedic Journal of Sports Medicine (2015)

Objectives: Athletes commonly wear fitted silicone ankle sleeves (SAS) and lace-up ankle braces (LAB). There is limited data about their effect on neuromuscular control or athletic performance. Our goal is to evaluate their efficacy in a yo...

DOAJ Open Access (DOAJ) DOI: 10.1177/2325967115S00042

Impact of pneumonia and lung cancer on mortality of women with hypertension

Yuechun Shen, Zuojun Tian, Dongfeng Lu, Junyao Huang et al. • Scientific Reports (2016)

Abstract Essential hypertension is one of the most severe women’s health problems. Modern life brings more chances of pulmonary diseases to human. The purpose of the study is to investigate weather pneumonia and lung cancer are associated w...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-016-0023-2

Artificial intelligence for pediatric height prediction using large-scale longitudinal body composition data

Dohyun Chun, Hae Woon Jung, Jongho Kang, Woo Young Jang et al. • Digital Health (2025)

Objective We developed a precise, reliable artificial intelligence (AI) model for predicting the future height of children and adolescents based on anthropometric and body composition data. Materials and Methods We used an extensive longitu...

DOAJ Open Access (DOAJ) DOI: 10.1177/20552076251395975

Tirzepatide versus GLP-1 receptor agonists and stroke in patients with atrial fibrillation and type 2 diabetes

Chih-Lang Lin, Kuan-Chou Lin, Jung-Min Yu, Chia-Lun Chang et al. • Nature Communications (2026)

Abstract Patients with atrial fibrillation and type 2 diabetes remain at high risk of stroke despite anticoagulation and glucose-lowering treatment. We examined whether tirzepatide was associated with lower cerebrovascular risk than establi...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-026-77047-5

Comparative Immunogenicity and Safety of Measles-Mumps-Rubella Vaccine When Administered Using Needle Free Injection System to That with Conventional Needle-Syringe in India: A Randomized, Parallel Group Study

Ratta BS, Naik A, Mutha S • Medical Devices: Evidence and Research (2025)

B S Ratta,1,* Ankur Naik,2,* Sarvesh Mutha3,* 1Consultant Paediatric Surgeon, Ruby Hall Clinic, Pune, India; 2Chief Technology Officer, IntegriMedical Private Limited, Pune, India; 3Chief Business Officer, IntegriMed...

DOAJ Open Access (DOAJ)

Expert Consensus on Diagnosis and Management of Secondary Sarcopenia in Adults in Colombia: A Modified Delphi Study

Claudia Contreras, Diana Paola Córdoba‐Rodríguez, Robinson Cuadros, José Ricardo Jauregui et al. • JCSM Communications (2026)

ABSTRACT Background Secondary sarcopenia driven by chronic disease, acute illness, immobilization, malnutrition or treatment‐related factors contributes to functional decline, falls, disability, readmission and mortality. In Colombia, uneve...

DOAJ Open Access (DOAJ) DOI: 10.1002/rco2.70051

Long Noncoding RNAs in Neurodegenerative Diseases: Pathogenesis and Potential Implications as Clinical Biomarkers

Meng Zhang, Ping He, Zhigang Bian • Frontiers in Molecular Neuroscience (2021)

Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are progressive and ultimately fatal. NDD onset is influenced by several fa...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2021.685143

Higher calorie intake with adequate exercise is associated with reduced mortality compared with low-calorie diet with equivalent exercise: An observational study from NHANES based on the 2020–2025 Dietary Guidelines for Americans

Hanghang Gan, Yu Yan, Shanshan Jia, Yingqiang Guo et al. • Experimental Gerontology (2025)

Object: To explore the effects of different combinations of calorie intake and exercise on all-cause, cardiovascular and cancer mortality. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weigh...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.112805

The interplay of risk factors for future falls and fall-related injuries among community-dwelling older adults: a Bayesian network analysis

Yan Cai, Wei Zhu, Chenshu Wu, Yan Jiang • BMC Public Health (2026)

Abstract Background Falls are a leading global cause of injury and mortality in older adults, necessitating understanding risk factor interplay for prevention. This study aims to investigate complex interactions among risk factors associate...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12889-026-27192-9