Academic Articles & Research Papers

NIR-Responsive Mitochondria-Targeted Liposomal Covalent Organic Framework for Combined Cancer Therapy.

Preparation of liposomal amiodarone and investigation of its cardiomyocyte-targeting ability in cardiac radiofrequency ablation rat model

Ying Zhuge,1,* Zhi-Feng Zheng,1,* Mu-Qing Xie,2 Lin Li,2 Fang Wang,1 Feng Gao2,3 1Department of Cardiology, Shanghai First People’s Hospital of Nanjing Medical University, 2Department of Pharmaceutics, School of Pharmacy, 3Shanghai Ke...

A confirmatory analysis of the knowledge, attitudes, and perceptions questionnaire for community-based surveillance of infectious diseases: a cross-sectional study in Malaysia

Objectives This study aimed to validate the psychometric properties of the recently developed knowledge, attitudes, and perceptions questionnaire for community-based surveillance of infectious diseases (KAP-CBS-ID questionnaire), using conf...

Integrating ayurvedic eye care into primary health practice: an exploratory study on the combined effect of pratimarsha nasya, avagundana, and aschyotana in meibomian gland dysfunction

BackgroundMeibomian Gland Dysfunction (MGD) has become increasingly common in community practice, often presenting as dryness, irritation, and ocular fatigue. Factors such as prolonged screen exposure, environmental irritants, and advancing...

The use of tear ferning test in cats for evaluation of ocular surface

Abstract Background The tear film is a trilaminar fluid composed mainly of lipids, electrolytes, proteins and water. It is responsible for lubrication, nutrition and protection against microbial and toxic agents. Disruption of any these com...

Longitudinal Functional and Safety Outcomes in Chronic Post-Ischemic Stroke Following a Multimodal Regenerative Medicine Protocol: A Case Report.

Risk Stratification of Elderly Patients Undergoing Spinal Surgery Using the Modified Frailty Index

Study Design: Retrospective cohort. Objectives: To validate the 11-item modified Frailty Index (mFI) as a perioperative risk stratification tool in elderly patients undergoing spine surgery. Methods: All consecutive cases of spine surgery i...

Guidelines for information about therapy experiments: a proposal on best practice for recording experimental data on cancer therapy

Abstract Background Biology, biomedicine and healthcare have become data-driven enterprises, where scientists and clinicians need to generate, access, validate, interpret and integrate different kinds of experimental and patient-related dat...

Metal-Organic Framework-Based Nanomedicines for Cancer Therapy: A Proposed Delivery Framework for Executable Cuproptosis.

Evaluation of recombinant activated protein C for severe sepsis at a tertiary academic medical center

Kevin E Anger,1 Jeremy R DeGrado,1 Bonnie C Greenwood,1 Steven A Cohen,2 Paul M Szumita1 1Department of Pharmacy, Brigham and Women’s Hospital, Boston, MA, USA; 2Department of Family Medicine and Population Health, Division of Epidemi...

Pterocarpus santalinus (Red Sanders) an Endemic, Endangered Tree of India: Current Status, Improvement and the Future

Pterocarpus santalinus (Family – Fabaceae) popularly known as Red Sanders is an endemic species confined to Southern parts of Eastern Ghats of India specially in Andhra Pradesh. Heartwood of Red Sanders has high demand in domestic as well a...

Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review

Abstract Patchouli (“Guanghuoxiang”) or scientifically known as Pogostemon cablin Benth, belonging to the family Lamiaceae, has been used in traditional Chinse medicine (TCM) since the time of the Eastern Han dynasty. In TCM theory, patchou...

Cascading Training Model to Promote Screening, Brief Intervention, and Referral to Treatment Across South Africa: Rollout in an HIV Service Organization

Background In South Africa, rates of HIV and alcohol use are among the highest globally, with a detrimental synergistic relationship. Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based, cost-effective appr...

Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings.

The study of continuously varying, quantitative traits is important in evolutionary biology, agriculture, and medicine. Variation in such traits is attributable to many, possibly interacting, genes whose expression may be sensitive to the e...

Meticulous parade on naringin respecting its pharmacological activities and novel formulations

Objective: Medicinal plants having antioxidant potential possess numerous constituents which are responsible for different beneficial effects and are used as an alternative resource of medicine to lessen diseases linked with oxidative stres...

The association between adolescent mental health and oral health behavior: The Luxembourg Health Behavior in School-Aged Children study

Oral health remains a global health problem. Mental health has been linked to oral health behavior. However, studies among adolescents in high-income countries are limited. This study aimed to investigate the association between adolescent ...

Automated patient and medication payment method for clinical trials

Barbara P Yawn,1 Suzanne Madison,1 Susan Bertram,1 Wilson D Pace,2 Anne Fuhlbrigge,3 Elliot Israel,3 Dawn Littlefield,1 Margary Kurland,1 Michael E Wechsler41Olmsted Medical Center, Department of Research, Rochester, MN, 2UCDHSC, Department...

Past, present, and future of thermogenic fat research: A bibliometric analysis from 2000 to 2023.

Integrating metabolomics and transcriptomics to investigate the effects of changes in renal adenosine 5'-monophosphate and arginine metabolism on the mTOR pathway under chronic hypoxia.

Case Report: A novel variant in fibrillin-2 identified in a congenital contractural arachnodactyly family with phenotypic heterogeneity.