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ROS/Enzyme Dual-Responsive Drug Delivery System for Targeted Colorectal Cancer Therapy: Synergistic Chemotherapy, Anti-Inflammatory, and Gut Microbiota Modulation

Xin Zhang, Ruonan Lian, Bingbing Fan, Lei Meng et al. • Pharmaceutics (2025)

Objectives: Colorectal cancer (CRC) is a leading cause of cancer-related mortality, driven by chronic inflammation, gut microbiota dysbiosis, and complex tumor microenvironment interactions. Current therapies are limited by systemic toxicit...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics17070940

An innovative and sustainable design of intangible Miao wax printing patterns in combination of diffusion model and fuzzy TOPSIS

Xinhui Kang, Wenjie You, Huaqian Xie • Humanities & Social Sciences Communications (2025)

Abstract Miao wax printing is a dyeing and weaving process in which natural dyes replace chemical dyes. It is renowned for its unique patterns and exquisite craftsmanship. However, with the development of industrialization and the decreasin...

DOAJ Open Access (DOAJ) DOI: 10.1057/s41599-025-05724-9

Discovery of sulfone-resistant dihydropteroate synthase (DHPS) as a target enzyme for kaempferol, a natural flavanoid

Angamba Meetei Potshangbam, Ravindranath Singh Rathore, Potshangbam Nongdam • Heliyon (2020)

Kaempferol is a ubiquitous flavonoid, found in various plants having a wide range of known pharmacological activities, including antioxidant, antiinflammatory, anticancer, antiallergic, antidiabetic, neuroprotective, cardioprotective and an...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2020.e03378

Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product

Mariia Shanaida, Nataliia Hudz, Izabela Jasicka-Misiak, Piotr P. Wieczorek • Frontiers in Pharmacology (2021)

This study aimed to determine the composition and content of polyphenols in the dry extract obtained from the hydrodistilled residue by-product of the wild bergamot (Monarda fistulosa L., Lamiaceae Martinov family) herb (MFDE) and to evalua...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2021.563436

Chemosensory-Related Genes in Marine Copepods

Vittoria Roncalli, Marco Uttieri, Iole Di Capua, Chiara Lauritano et al. • Marine Drugs (2022)

Living organisms deeply rely on the acquisition of chemical signals in any aspect of their life, from searching for food, mating and defending themselves from stressors. Copepods, the most abundant and ubiquitous metazoans on Earth, possess...

DOAJ Open Access (DOAJ) DOI: 10.3390/md20110681