Academic Articles & Research Papers

Bone morphogenetic protein 4 meets artificial intelligence: a comprehensive review of AI-driven advances in drug discovery, structural modeling, and clinical translation.

Can autonomous Agentic-AI systems accelerate drug discovery and development in the next decade?

AI agents in drug discovery: applications and case studies.

Nanotechnology in ocular drug delivery

Cancer nanotechnology: application of nanotechnology in cancer therapy

Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...

Metabolic modeling-based drug repurposing in Glioblastoma

Abstract The manifestation of intra- and inter-tumor heterogeneity hinders the development of ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type. Specifically, the reprogramming of cellular metabolism has b...

Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages

Abstract Background Dysregulation of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) form the basis of immune-mediated inflammatory diseases. Vitex trifolia L. is a medicinal plant growing in co...

Essential requirement of complex number for oscillatory phenomenon in intracellular trafficking process

Intracellular protein trafficking processes consisting of three intracellular states are described by three differential equations. To solve the equations, a quadratic equation is required, and its roots are generally real or complex. The p...

Identification of Eusynstyelamide B as a Potent Cell Cycle Inhibitor Following the Generation and Screening of an Ascidian-Derived Extract Library Using a Real Time Cell Analyzer

Ascidians are marine invertebrates that have been a source of numerous cytotoxic compounds. Of the first six marine-derived drugs that made anticancer clinical trials, three originated from ascidian specimens. In order to identify new anti-...

A hybrid plasmid formed by recombination of a virulence plasmid and a resistance plasmid in Klebsiella pneumoniae

Objective: The emergence of multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae (hvKP) facilitates simultaneous dissemination of virulence and resistance in a single event, which poses serious threat to public health. Methods:...

Quantum computing in medical informatics

In an era of exponential technological advancements, the integration of quantum computing (QC) and medical informatics emerges as a captivating frontier, promising to unlock a new realm of possibilities for healthcare. QC, harnessing the pr...

The deep learning applications in IoT-based bio- and medical informatics: a systematic literature review

Abstract Nowadays, machine learning (ML) has attained a high level of achievement in many contexts. Considering the significance of ML in medical and bioinformatics owing to its accuracy, many investigators discussed multiple solutions for ...

The Traditional Medicine and Modern Medicine from Natural Products

Natural products and traditional medicines are of great importance. Such forms of medicine as traditional Chinese medicine, Ayurveda, Kampo, traditional Korean medicine, and Unani have been practiced in some areas of the world and have blos...

QUANTUM COMPUTING

Quantum computing is a revolutionary approach to computation that uses the peculiar principles of quantum mechanics, a branch of physics that describes the behaviour of particles at the microscopic level. By offering solutions that are curr...

QUANTUM COMPUTING

Quantum Computing represents a paradigm shift in computation, leveraging the principles of quantum mechanics to solve problems intractable for classical computers. This book provides a comprehensive exploration of quantum computing, encompa...

From molecules to data: the emerging impact of chemoinformatics in chemistry

Abstract Chemoinformatics is a rapidly advancing field that integrates chemistry, computer science, and data analysis to enhance the study and application of chemical systems. This interdisciplinary approach leverages computational tools an...

The prospects of quantum computing in computational molecular biology

Abstract Quantum computers can in principle solve certain problems exponentially more quickly than their classical counterparts. We have not yet reached the advent of useful quantum computation, but when we do, it will affect nearly all sci...

Commercial applications of quantum computing

Despite the scientific and engineering challenges facing the development of quantum computers, considerable progress is being made toward applying the technology to commercial applications. In this article, we discuss the solutions that som...

Potential of quantum computing for drug discovery

Quantum computing has rapidly advanced in recent years due to substantial development in both hardware and algorithms. These advances are carrying quantum computers closer to their impending commercial utility. Drug discovery is a promising...