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Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition

Pei-Iun Hsieh, Te-Hsuan Huang, Jeng-Min Chiou, Jen-Hau Chen et al. • Epidemiology and Health (2024)

The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with the aim of identifying older adul...

DOAJ Open Access (DOAJ) DOI: 10.4178/epih.e2024057

Factors Associated with Quality of Life Among Older Adults with Chronic Disease in Taiwan

Hsiao-Mei Chen, Ching-Min Chen • International Journal of Gerontology (2017)

Background: There have been many studies reviewing quality of life (QoL) of older population and found an inverse association between QoL and chronic diseases. However, previous studies have focused only on that of people with specific dise...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ijge.2016.07.002

Correlation between sarcopenia and changes in oligodendrocyte lineage cells in the brains of Alzheimer's disease model mice

Lin-lin Yao, Xiao-ting Ma, Fang-bo Li, Lin-yi Zheng et al. • Experimental Gerontology (2026)

Background: Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by cognitive dysfunction. The discovery and identification of non-cognitive symptoms in the preclinical stage hold promise for early diagnosis and ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2026.113057

Correlation between frailty and reduction in cortical thickness in patients with chronic obstructive pulmonary disease

Ayumi Fukatsu-Chikumoto, Tsunahiko Hirano, Shun Takahashi, Takuya Ishida et al. • Scientific Reports (2024)

Abstract Physical inactivity and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD) can lead to frailty and poor prognoses. However, little is known regarding the association between frailty and the human bra...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-024-53933-0

Optimal exercise type and dose to improve sleep quality in older adults: a systematic review and network meta-analysis

Zhiyu Xiong, Yuan Yuan, Bopeng Qiu, Yong Yang et al. • BMC Geriatrics (2025)

Abstract Background Sleep quality decreased can result in a major health issue in older people with age. While not all sleep changes are pathological in older people’s life, severe disturbances may lead to depression, cognitive impairments,...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-025-06607-z

Time-in-range and hypoglycemia in cognitive health of older adults with Type 2 diabetes: An emerging evidence synthesis

Dharmendra Kumar Gupta, Arunima Chaudhuri • Muller Journal of Medical Sciences and Research (2026)

Type 2 diabetes mellitus (T2DM) is a recognized risk factor for cognitive decline and dementia, but the mechanisms linking glycemic dysregulation to brain health remain incompletely understood. Glycated hemoglobin captures long-term average...

DOAJ Open Access (DOAJ) DOI: 10.4103/mjmsr.mjmsr_83_25

Association of inflammation and cognition in the elderly: A systematic review and meta-analysis

Sofia Leonardo, Felipe Fregni • Frontiers in Aging Neuroscience (2023)

BackgroundThe development of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) may be associated with an inflammatory process. Inflammatory cytokines may be a surrogate for systemic inflammation leading to worsening neurological ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnagi.2023.1069439

Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19

Dayoung Seo, Yangsean Choi, Eunseon Jeong, Sanghwi Bang et al. • Nature Communications (2025)

Abstract Although brain alterations have been reported in post-acute sequelae of SARS-CoV-2 (PASC), their prevalence and relationship to neurodegeneration remain unclear. We analyzed blood proteins and brain MRI from individuals approximate...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-025-65597-z