C Research Papers

Challenges and approaches to genetic variants of uncertain significance in clinical practice and research.

Li Q, Morton SU, Luo S, Stark Z et al. • Genome medicine (2026)

PMC PMC Public Access (View-Only) DOI: 10.1186/s13073-026-01740-9 PMC: PMC13737733

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Explicating the work of regional leads in implementing at scale: a qualitative study of the perinatal optimisation care pathway.

Roberts J, Anderson J, Armstrong N, Boyle E et al. • Implementation science communications (2026)

PMC PMC Public Access (View-Only) DOI: 10.1186/s43058-026-01061-3 PMC: PMC13737671

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Development and validation of a latex-based lateral flow assay for the serological diagnosis of feline leishmaniosis caused by Leishmania infantum.

Puerta López G, Drakouli S, Tarragó Del Río M, Sánchez López I et al. • Parasites & vectors (2026)

PMC PMC Public Access (View-Only) DOI: 10.1186/s13071-026-07625-5 PMC: PMC13737760

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Combining MAVEs and computational predictors improves variant classification across ancestries in hereditary cancer genes.

Bora N, Badonyi M, Pathak AK, Manisekaran RG et al. • Genome medicine (2026)

PMC PMC Public Access (View-Only) DOI: 10.1186/s13073-026-01799-4 PMC: PMC13737655

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Costing implementation strategies using Cost-IS: a multiple case study.

Donovan T, Abell B, McPhail SM, Carter HE • Implementation science communications (2026)

PMC PMC Public Access (View-Only) DOI: 10.1186/s43058-026-01071-1 PMC: PMC13737672

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Acceptability, appropriateness, sustainment, and implementation cost of a multicomponent strategy to increase HPV vaccination in pediatric primary care: secondary results of a cluster-randomized trial.

Wang R, Dodd S, Rook S, Graham S et al. • Implementation science communications (2026)

PMC PMC Public Access (View-Only) DOI: 10.1186/s43058-026-01068-w PMC: PMC13737714

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Harnessing metatranscriptomics to unveil the metabolic landscape of microbiota in traditional fermented foods.

Li R, Fan X, Kang J, Huang X et al. • Current research in food science (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.crfs.2026.101601 PMC: PMC13734766

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Frequency-dependent thalamocortical transfer limits sustained cortical expression of sensory drive.

Yu Z, Wang H, Zhuo Y, Zuo Z • iScience (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.isci.2026.118035 PMC: PMC13734801

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Forensic delivery of intelligence outcomes: Quality considerations.

Taylor ML, Heavey AL • Forensic science international. Synergy (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.fsisyn.2026.100748 PMC: PMC13734822

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Therapeutic HPV16 E7 vaccination with CD137 agonism induces tumor regression and durable immunity in mice.

Ou Y, Lu W, Zhao H, Demetrious C et al. • iScience (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.isci.2026.118018 PMC: PMC13734790

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Toll-like receptor 4-driven translational reprogramming in macrophages is unaffected by Salmonella SPI-1 activity.

Wood G, Johnson R, Brember MP, Lastovka F et al. • iScience (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.isci.2026.117901 PMC: PMC13734781

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An engineered α-1,3-glucanase-derived probe enables sensitive detection of α-1,3-glucan and reveals its soluble release by Aspergillus.

Suzuki K, Kimura M, Miyazawa K, Adachi Y et al. • iScience (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.isci.2026.117952 PMC: PMC13734777

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Three-dimensional culture suppresses pancreatic fibroblast activation and limits paracrine signaling between pancreatic cancer cells and fibroblasts.

Javakhishvili N, Zourelidis A, Trojanowicz B, Sunami Y et al. • Biochemistry and biophysics reports (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.bbrep.2026.102843 PMC: PMC13734846

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pH/ROS dual-responsive SmartGel-Cas9/TRPV4 for autophagy regulation in intervertebral disc degeneration.

Yu XJ, Quan BY, Zou P, Wang SB et al. • Materials today. Bio (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.mtbio.2026.103768 PMC: PMC13734901

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miR-7a-5p attenuates hypoxic-ischemic encephalopathy by suppressing PARP1-mediated parthanatos.

Chen D, Kong X, Zhong H, Zhang Y et al. • iScience (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.isci.2026.117947 PMC: PMC13734944

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Draft genome sequences and pan-genome of Bacillus Bac5 and Bac6 strains isolated from a mangrove ecosystem with anti-Vibrio activity.

Reyes G, Sorroza L • Data in brief (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.dib.2026.113363 PMC: PMC13734949

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Bioactive isoprenylflavonoids contribute to the dual protective effects of Xianling Gubao against sarcopenia and osteoarthritis in SAMP8 mice.

Yang W, Gao B, Li J, Meng X et al. • Journal of orthopaedic translation (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.jot.2026.101252 PMC: PMC13734936

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Targeting TRP channels in hearing loss from mechanisms to otoprotection.

Yang Y, Li S, Xie L, Li J et al. • iScience (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.isci.2026.117939 PMC: PMC13734937

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Adenoviral vector co-expressing ALDH1 and ADH1 mitigates alcohol toxicity and modulates glucose and lipid metabolism.

Yan Y, Wang X, Shi H, Zhu C et al. • iScience (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.isci.2026.118019 PMC: PMC13734968

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NR2F6 functions as a key transcriptional checkpoint enforcing dysfunction of human CD3(+) T cells and limiting CAR-T cell potency.

Koutník J, Gruber T, Freimark D, Humer D et al. • iScience (2026)

PMC PMC Public Access (View-Only) DOI: 10.1016/j.isci.2026.117982 PMC: PMC13734946

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