Artificial Intelligence, Machine Learning, and Cognitive Science Research Papers

Development and validation of an interpretable machine learning model for predicting the risk of coronary heart disease risk in diabetes mellitus patients: a dual-center retrospective study

Abstract Background Diabetes mellitus (DM) combined with coronary heart disease (CHD) significantly increases the risk of cardiovascular events with a greater mortality rate. Therefore, establishing a predictive model can help DM patients r...

Integrating machine learning algorithms and explainable artificial intelligence approach for predicting patient unpunctuality in psychiatric clinics

This study addresses patient unpunctuality, a major concern affecting patient waiting time, resource utilization, and quality of care. We develop and compare four machine learning models, including multinomial logistic regression, decision ...

A novel and accelerated method for integrated alignment and variant calling from short and long reads

BackgroundIntegrating short- and long-read sequencing technologies has become a promising approach for achieving accurate and comprehensive genomic analysis. Although short-read sequencing (Illumina, etc.) offers high base accuracy and cost...

The influence of patient characteristics on the alarm rate in intensive care units: a retrospective cohort study

Abstract Intensive care units (ICU) are often overflooded with alarms from monitoring devices which constitutes a hazard to both staff and patients. To date, the suggested solutions to excessive monitoring alarms have remained on a research...

Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

Exploring health literacy pertaining to general wellbeing and chronic disease management among population registered within Primary Healthcare System: A Study protocol.

BackgroundEvidence suggests that high level of health literacy among patients is associated with high levels of accessibility to healthcare, better understanding consent-to-treat forms, increased compliance to treatment (particularly in tak...

Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors

DNA methylation plays an important role in silencing transposable elements. Here the authors find that loss of DNMT1 and DNA methylation leads to transcriptional activation and chromatin remodelling of evolutionarily young—hominoid-specific...

In vitro inhibition of SARS-CoV-2 Infection by dry algae powders

Abstract Chlorella spp., Spirulina spp., and fucoidan dry powders, are commercialized as food supplements and are considered safe for human consumption. Their broad-spectrum antiviral properties have been studied, however, their effect agai...

Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels

The growing recognition of the health-promoting potential of compounds derived from natural sources, particularly those exhibiting antimicrobial and antioxidant activities, has resulted in a surge of research publications dedicated to explo...

Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice

Abstract The SARS-CoV-2 virus caused the most severe pandemic around the world, and vaccine development for urgent use became a crucial issue. Inactivated virus formulated vaccines such as Hepatitis A and smallpox proved to be reliable appr...

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Abstract Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, espec...

Investigating the genetic makeup of the major histocompatibility complex (MHC) in the United Arab Emirates population through next-generation sequencing

Abstract The Human leukocyte antigen (HLA) molecules are central to immune response and have associations with the phenotypes of various diseases and induced drug toxicity. Further, the role of HLA molecules in presenting antigens significa...

Specific egg yolk immunoglobulin as a promising non-antibiotic biotherapeutic product against Acinetobacter baumannii pneumonia infection

Abstract Acinetobacter baumannii is a serious health threat with a high mortality rate. We have already reported prophylactic effects of IgYs raised against OmpA and Omp34 as well as against inactivated whole-cell (IWC) of A. baumannii in a...

KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors

Abstract KRAS mutations are broadly recognized as promising targets for tumor therapy. T cell receptors (TCRs) can specifically recognize KRAS mutant neoantigens presented by human lymphocyte antigen (HLA) and mediate T cell responses to el...

Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Abstract For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effec...

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

How Does the Diversity of Divers Affect the Design of Citizen Science Projects?

Divers have widely participated in citizen science (CS) projects and are one of the main groups of marine citizen scientists. However, there is little knowledge about profiles of, and incentives for potential divers to join CS projects. To ...

Intellectual property and artificial intelligence

Issues, arising in the field of intellectual property rights in connection with the development of artificial intelligence systems and their impact on the development of legal relations in the economy and culture of modern society, have bee...

Artificial Intelligence, Green Innovation, and the Clean-Energy Market: A Quantile-Based Analysis

Artificial intelligence is increasingly viewed as both a catalyst for clean-energy development and a potential constraint on green innovation. This study examines the quantile-specific relationships between artificial intelligence, clean-en...

Information Security in the Countries of Central Asia: the Case of Kazakhstan

The article discusses the history of the creation and development of the overall concept of information security, the current state of the information security, as well as the appropriate legal and regulatory framework in the countries of C...