Reset
Showing 20 of 950 academic articles

Changing trends of blindness, visual impairment and cataract surgery in Bhutan: 2009-2018.

Nor Tshering Lepcha, Indra Prasad Sharma, Yuddha Dhoj Sapkota, Taraprasad Das et al. • PLoS ONE (2019)

PurposeTo obtain new rapid assessment of avoidable blindness (RAAB) data on the prevalence, causes and trends of blindness, visual impairment and cataract surgery; and compare the new 2018 data with the older RAAB 2009 data.MethodologyThe s...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0216398

Human cardiac innervation-on-a-chip platform recapitulates neurocardiac interactions and supports future disease modeling

Emma Pesu, Elias Kuusela, Anna-Mari Moilanen, Andrey Vinogradov et al. • Scientific Reports (2026)

Abstract The cardiac autonomic nervous system regulates cardiac function through innervation, and dysfunction of the neuronal and cardiovascular crosstalk has been linked to various pathologies. Here, we present a cardiac innervation-on-a-c...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-026-62182-2

A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients

Chirajyoti Deb, Allan N. Salinas, Tianyu Zheng, Aurea Middleton et al. • Scientific Reports (2021)

Abstract Upon infection with SARS-CoV-2, the virus that causes COVID-19, most people will develop no or mild symptoms. However, a small percentage of the population will become severely ill, and some will succumb to death. The clinical seve...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-021-02863-2

The Protective Effect of Sulforaphane against Oxidative Stress through Activation of NRF2/ARE Pathway in Human Granulosa Cells

Sahar Esfandyari, Ashraf Aleyasin, Zahra Noroozi, Maryam Taheri et al. • Cell Journal (2021)

Objective: Sulforaphane (SFN) is a natural free radical scavenger that can reduce oxidative stress (OS) through mediating nuclear factor (erythroid-derived 2)-like 2 (NF-E2-related factor 2 or NRF2)/antioxidant response element (ARE) signal...

DOAJ Open Access (DOAJ) DOI: 10.22074/cellj.2021.7393

Pan bread quality as affected by some nano and fermented-nano food industries by-products

El-Sayed I. Yousif, Attia A. Yaseen, Abdel-Fatah A. Abdel-Fatah, Abdel-Hafeez A. Shouk et al. • Bulletin of the National Research Centre (2020)

Abstract Background Rapid development of nanotechnology is expected to transform many areas of food technology with increasing investment and market share. Also, phytochemical-rich foods have attracted consumer’s attention due to their abil...

DOAJ Open Access (DOAJ) DOI: 10.1186/s42269-020-00315-x

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin et al. • Nature Communications (2024)

Abstract Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-024-47424-z

Influence of Different Disinfectants on Surface Hardness of Heat-Polymerized Acrylic Resins utilized for Orthodontic Appliance

Wael Abdul Alrazzaq Alwaeli, Mohammed Abdul Sattar Alsegar • Journal of Techniques (2021)

Heat-polymerized resins are common substances utilized for construction of removable dental prostheses (i.e. Orthodontic appliances). Such materials should have appropriate physical properties. The use of disinfectant solutions might influe...

DOAJ Open Access (DOAJ) DOI: 10.51173/jt.v3i1.286

Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila

Cagri Yalgin, Bohdana Rovenko, Ana Andjelković, Margot Neefjes et al. • iScience (2020)

Summary: Dopaminergic (DA) neurons have been implicated as key targets in neurological disorders, notably those involving locomotor impairment, and are considered to be highly vulnerable to mitochondrial dysfunction, a common feature of suc...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.isci.2020.101362

Development and usability of VRainSUD’s cognitive training virtual reality platform for substance use disorders

Tânia Caetano, Maria Salomé Pinho, Hugo Freire, Dany Mota et al. • Scientific Reports (2025)

Abstract Cognitive deficits have been shown to increase the likelihood of relapse in individuals with substance use disorders (SUD). As such, cognitive training programs are important interventions for this population. In this study, we des...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-00922-6

Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved]

Neil Barnes Abraham, Abhimanyu Pradhan, Suresh Sukumar, Sneha Ravichandran et al. • F1000Research (2025)

Background Breast cancer remains a significant global health concern, with early diagnosis and risk factor identification crucial for improving outcomes. Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) measurements...

DOAJ Open Access (DOAJ) DOI: 10.12688/f1000research.153999.3

A qualitative study exploring community pharmacists’ perspectives of child and adolescent mental healthcare

Irene A. Kretchy, Edem K. Blewuada, Akosua B. Debrah • Scientific African (2021)

Community pharmacists are involved in the health delivery sector through the provision of services that result in improved patient outcomes and optimization of pharmaceutical care. With growing concern about increasing prevalence of mental ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.sciaf.2021.e00969

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer

Yundong He, Ting Wei, Zhenqing Ye, Jacob J. Orme et al. • Nature Communications (2021)

Resistance to second generation anti-androgen therapies such as enzalutamide (ENZ) can emerge in prostate cancer patients. Here, the authors identify an ENZ-resistant mechanism driven by AR-dependent transcription of noncanonical targets th...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-021-21860-7

Dichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization

Natalia Andelova, Iveta Waczulikova, Lukas Kunstek, Ivan Talian et al. • Scientific Reports (2022)

Abstract Myocardial compensatory mechanisms stimulated by reduced oxygen utilization caused by streptozotocin-induced diabetes mellitus (DM) and treated with dichloroacetate (DCA) are presumably associated with the regulation of mitochondri...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-022-20696-5

Medical, dental, and nursing students’ attitudes and knowledge towards artificial intelligence: a systematic review and meta-analysis

Hamidreza Amiri, Samira Peiravi, Seyedeh sara rezazadeh shojaee, Motahareh Rouhparvarzamin et al. • BMC Medical Education (2024)

Abstract Background Nowadays, Artificial intelligence (AI) is one of the most popular topics that can be integrated into healthcare activities. Currently, AI is used in specialized fields such as radiology, pathology, and ophthalmology. Des...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12909-024-05406-1

Deep learning-based multimodal data fusion in bone tumor management: Advances in clinical decision support

Tongtong Huo, Wei Wu, Xiaoliang Chen, Mingdi Xue et al. • Intelligent Oncology (2025)

Bone tumors (BTs)—including osteosarcoma, Ewing sarcoma, and chondrosarcoma—are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location, histological subtype, and molecular alterations. Re...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.intonc.2025.06.005

Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity

Maaike C. Swets, Steven Kerr, James Scott-Brown, Adam B. Brown et al. • Nature Communications (2023)

Abstract Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the $$S/F$...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-023-42205-6

Automated measurement of CD8+ T-cell distribution at the tumor epithelial–stromal interface is associated with NSCLC immunotherapy benefit and transcriptomic pathways

Patrick Leo, Hauke Kolster, Hartmut Koeppen, Jennifer Giltnane et al. • Journal of Pathology Informatics (2026)

Whereas anti-PD-(L)1 therapies are widely used in cancer treatment, only a subset of patients achieve long-term survival. Companion diagnostics based on PD-L1 expression have limited predictive power for these therapies, motivating developm...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jpi.2026.100688

Behavioral dataset for Long-Evans and its schizophrenia-like substrain through several generations

Gábor Kőrösi, Oliver Czimbalmos, Gabriella Kekesi, Gyongyi Horvath • Scientific Data (2026)

Abstract We present a high-throughput behavioral dataset acquired with Ambitus, an automated reward-based corridor system that records locomotor and exploratory activities and cognitive functions after minimal handling. The collection conta...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41597-026-06735-0