Characterization data on the topical carrier DDC642
Eline Desmet
(Department of Dermatology, Ghent University, Ghent, Belgium; Corresponding author at: Department of Dermatology, Ghent University, De Pintelaan 185, Vijverpark, B-9000 Ghent, Belgium. Tel: +32 (0)9 332 65 43.)
Stefanie Bracke
(Department of Dermatology, Ghent University, Ghent, Belgium)
Katrien Forier
(Department of Pharmaceutics, Ghent University, Ghent, Belgium; Center of Nano and Biophotonics, Ghent University, Ghent, Belgium)
Lien Taevernier
(Department of Pharmaceutical Analysis, Ghent University, Ghent, Belgium)
Marc C.A. Stuart
(Electron microscopy, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands)
Bart De Spiegeleer
(Department of Pharmaceutical Analysis, Ghent University, Ghent, Belgium)
Koen Raemdonck
(Department of Pharmaceutics, Ghent University, Ghent, Belgium)
Mireille Van Gele
(Department of Dermatology, Ghent University, Ghent, Belgium)
Jo Lambert
(Department of Dermatology, Ghent University, Ghent, Belgium)
Journal: Data in Brief
•
• Elsevier
• ISSN: 2352-3409
Abstract
This article contains original data, figures and methods used in the characterization of the liposomal carrier ‘DDC642’ for topical applications, described in “An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis” (Desmet et al., 2016) [1]. Several elastic liposomal formulations have been evaluated for their ability to encapsulate and deliver RNA interference (RNAi) molecules to cultured primary skin cells. The efficiency and effectiveness of these liposomes were compared to that of our previously characterized liposomes, the ‘SECosomes’ (SEC) (Geusens et al., 2010) [2]. After selection of a potential superior carrier, based on encapsulation and transfection efficiency data (Desmet et al., 2016) [1], the selected DDC642 liposomes were characterized more in-depth. Herein, a detailed characterization of the DDC642 liposome and RNAi-loaded lipoplexes is given, including the matching protocols. Keywords: Gene therapy, Lipid-based nanoparticle, Liposome, RNA interference, Topical drug delivery
Eline Desmet, Stefanie Bracke, Katrien Forier, et al. (2016). "Characterization data on the topical carrier DDC642". Data in Brief. https://doi.org/10.1016/j.dib.2016.03.091