Tetrodotoxin: Chemistry, Toxicity, Source, Distribution  and Detection

Vaishali Bane; Mary Lehane; Madhurima Dikshit; Alan O'Riordan; Ambrose Furey

doi:10.3390/toxins6020693

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Vaishali Bane (Mass Spectrometry Research Centre (MSRC) and PROTEOBIO Research Groups, Department of Chemistry, Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland) Mary Lehane (Mass Spectrometry Research Centre (MSRC) and PROTEOBIO Research Groups, Department of Chemistry, Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland) Madhurima Dikshit (Department of Chemistry, University of Pune, Pune 411007, India) Alan O'Riordan (Nanotechnology Group, Tyndall National Institute, University College Cork, Lee Maltings, Cork, Ireland) Ambrose Furey (Mass Spectrometry Research Centre (MSRC) and PROTEOBIO Research Groups, Department of Chemistry, Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland)

Journal: Toxins • 2014-02-01 • MDPI AG • ISSN: 2072-6651

Abstract

Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan. TTX was believed to be confined to regions of South East Asia, but recent studies have demonstrated that the toxin has spread to regions in the Pacific and the Mediterranean. There is no known antidote to TTX which is a powerful sodium channel inhibitor. This review aims to collect pertinent information available to date on TTX and its analogues with a special emphasis on the structure, aetiology, distribution, effects and the analytical methods employed for its detection.

Subjects & Keywords

# Medicine # tetrodotoxin # TTX # TTX analogues # chemistry # toxicity # source # distribution # detection

How to Cite this Article

                    Vaishali Bane, Mary Lehane, Madhurima Dikshit, et al. (2014). "Tetrodotoxin: Chemistry, Toxicity, Source, Distribution  and Detection". Toxins. https://doi.org/10.3390/toxins6020693                

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DOI: 10.3390/toxins6020693 ↗
Primary Index: DOAJ